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Category: Bacterial Pathogenesis
Basic Bacteriology and Culture, Page 1 of 2
< Previous page | Next page > /docserver/preview/fulltext/10.1128/9781555818005/9781555812133_Chap04-1.gif /docserver/preview/fulltext/10.1128/9781555818005/9781555812133_Chap04-2.gifAbstract:
When a new slow-growing Campylobacter-like organism (CLO) was cultured by Marshall in 1982, it was classified as Campylobacter pyloridis and shortly after corrected to C. pylori. During the last decade, the genus Helicobacter has expanded tremendously and new species are regularly included. The majority of these new Helicobacter species are found in the stomachs and intestines of different animals. H. pylori has occasionally been cultured from ectopic gastric mucosa in Meckel's diverticulum, esophagus, rectum, urinary bladder, dental plaque, and feces. In very young cultures H. pylori may appear as almost straight rods on microscopy. Detection of H. pylori from extragastric specimens is carried out by culture and genome methods. Successful cultures have mainly been associated with findings of gastric metaplasia in esophagus, Meckel's diverticulum, and rectum, whereas in one case H. pylori could not be cultured from the gallbladder with gastric metaplasia. Occasionally, H. pylori has been cultured from dental plaque and fecal samples. In cell cultures, the initial contact and attachment of H. pylori to human gastric epithelial cells occur rapidly, often within minutes, at the aflagellated end of the bacterium.
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Virulence factors identified in H. pylori
Virulence factors identified in H. pylori