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Chapter 43 : Enterohepatic Helicobacter Species

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Abstract:

Most of the members of the genus do not normally colonize the gastric mucosa, but instead thrive in the mucosal surfaces of the intestinal tract and/or the liver of humans, other mammals, and birds. A growing number of enterohepatic species have also been reported to be associated with gastroenteritis, hepatitis, and other disease states in humans and in other animal species. The significance of the enterohepatic species in human disease and the true prevalence of these organisms in human populations remain to be determined. Chronic active hepatitis leading to hepatocellular neoplasia was also observed in germ-free female Swiss Webster mice following experimental infection with , clearly establishing the organism as a murine pathogen. has been documented as a cause of acute diarrhea in otherwise healthy individuals; however, bacteremia without gastroenteritis is more frequently associated with and infection in immunocompromised patients with AIDS or other underlying conditions. and have been shown to infect birds and mammals. By microscopic visualization, was found to have a higher density of colonization in the ileum than the cecum or colon in conventional mice and rats. can infect the stomach of mice and cause gastritis. Sequencing of PCR-amplified 16S rRNA gene fragments has been used to show that enterohepatic species can infect the gallbladder of humans with chronic cholecystitis.

Citation: Schauer D. 2001. Enterohepatic Helicobacter Species, p 533-548. In Mobley H, Mendz G, Hazell S (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555818005.ch43
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Figure 1

Transmission electron micrograph of H. hepaticus grown in pure culture (A), scanning electron micrograph of an organism with typical H. hepaticus ultrastructure in the intestine of a mouse (B), and transmission electron micrograph of H. hepaticus in the liver of a mouse (C). Bars, 1 µm. Originally from Fox and Lee ( ) (B) and Li et al. ( ) (C).

Citation: Schauer D. 2001. Enterohepatic Helicobacter Species, p 533-548. In Mobley H, Mendz G, Hazell S (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555818005.ch43
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Image of Figure 2
Figure 2

Transmission electron micrographs of “H. rappini” grown in pure culture (A), and in an intestinal crypt in a mouse (B), and scanning electron micrograph of “H. rappini” on the mucosal surface of the intestine of a mouse (C). Bars, 1 µm. Originally from Schauer et al. ( ).

Citation: Schauer D. 2001. Enterohepatic Helicobacter Species, p 533-548. In Mobley H, Mendz G, Hazell S (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555818005.ch43
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Tables

Generic image for table
Table 1

Selected characteristics of enterohepatic Helicobacter speciesa

Citation: Schauer D. 2001. Enterohepatic Helicobacter Species, p 533-548. In Mobley H, Mendz G, Hazell S (ed), . ASM Press, Washington, DC. doi: 10.1128/9781555818005.ch43

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