Chapter 14 : Potential Medical Impact of Endogenous Retroviruses

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The recent in vitro observation that porcine endogenous retroviruses (PERV) can infect human cells has ignited tremendous fear among investigators in the xenotransplantation field and health officials. This chapter reviews the available experience with other endogenous retroviruses in different animal situations, with the aim of better understanding the potential impact of such organisms in the field of xenotransplantation. All mammals that have been examined so far, including pigs and baboons, have endogenous retrovirus DNA sequences integrated in their genomes. Although transmitted in the germ line, they exhibit a very significant sequence homology to exogenous retroviruses. The true source of endogenous retroviruses remains to be elucidated. One hypothesis is that they are viral remnants of remote infections with exogenous forms of the virus. Alternative explanations include that retroviruses may be derived from retrotransposons or that endogenous retroviruses are the precursors of exogenous retroviral agents. The majority of endogenous retroviruses act as colonizers in the germ line of the host and are noninfectious. The exact functions of the remaining "competent" or partially defective endogenous retroviruses remain enigmatic. It is speculated that, among a number of possible functions, they may enhance the pathogenicity of exogenous retroviruses by the recombination and production of a hybrid virus with altered receptor specificity and species tropism, now capable of infecting a new range of hosts. New animal viruses are being discovered on a regular basis, as detection methods are becoming more sophisticated. Similarly, many more animal endogenous retroviruses are yet to be discovered and fully characterized.

Citation: Abu-Nader R, Paya C. 2001. Potential Medical Impact of Endogenous Retroviruses, p 251-259. In Platt J (ed), Xenotransplantation. ASM Press, Washington, DC. doi: 10.1128/9781555818043.ch14
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1. Akiyoshi, D. E.,, M. Denaro,, H. Zhu,, J. L. Greenstein,, P. Banerjee,, and J. Fishman. 1998. Identification of a full-length cDNA for an endogenous retrovirus of miniature swine. J. Virol. 72: 4503 4507.
2. Akiyoshi, D. E.,, I. Suzuka,, N. Shimizu,, K. Sekiguchi,, H. Hoshino,, M. Kodama,, and K. Shimotohno. 1986. Molecular cloning of unintegrated closed circular DNA of porcine retrovirus. FEBS Lett. 198: 339 343.
3. Allan, J. S.,, S. R. Broussard,, M. G. Michaels,, T. E. Starzl,, K. L. Leighton,, E. M. Whitehead,, A. G. Comuzzie,, R. E. Lanford,, M. M. Leland,, W. M. Switzer,, and W. Heneine. 1998. Amplification of simian retroviral sequences from human recipients of baboon liver transplants. AIDS Res. Hum. Retrov. 14: 82111 82114.
4. Bailey, L. L.,, S. L. Nehlsen-Cannarella,, W. Concepcion,, and W. B. Jolley. 1985. Baboon-to-human cardiac xenotransplantation in a neonate. JAMA 254: 3321 3329.
5. Barnard, C. N.,, A. Wolpowitz,, and J. G. Losman. 1977. Heterotopic cardiac transplantation with a xenograft for assistance of the left heart in cardiogenic shock after cardiopulmonary bypass. S. Afr. Med. J. 52: 1035 1039.
6. Boeke, J. D.,, and J. P. Stoye,. 1997. Retrotransposons, endogenous retroviruses, and the evolution of retroele-ments, p. 343 435. In J. M. Coffin,, S. H. Hughes,, and H. E. Varmus (ed.), Retroviruses. Cold Spring Harbor Press, Cold Spring Harbor, N.Y.
7. Brown, J.,, A. L. Matthews,, P. A. Sandstrom,, and L. E. Chapman. 1998. Xenotransplantation and the risk of retroviral zoonosis. Trends Microbiol. 6: 411 415.
8. Chari, R. S.,, B. H. Collins,, J. C. Magee,, M. DiMaio,, A. D. Kirk,, R. C. Harland,, R. L. McCann,, J. L. Piatt,, and W. C. Meyers. 1994. Brief report: treatment of hepatic failure with ex-vivo pig-liver perfusion followed by liver transplantation. N. Engl. J. Med. 331: 234 237.
9. Coffin, J. M., 1992. Structure and classification of retroviruses, p. 19 49. In J. A. Levy (ed.), The Retroviridae, vol. 1. Plenum Press, New York, N.Y.
10. Ehlers, B.,, S. TJlrich,, and M. Goltz. 1999. Detection of two novel porcine herpesviruses with high similarity to gammaherpesviruses. J. Gen. Virol. 80( PT4): 971 978.
11. Friedlander, A.,, and R. Patarca. 1999. Endogenous proviruses. Crit. Rev. Oncol. 10: 129 159.
12. Gao, F.,, E. Bailes,, D. L. Robertson,, Y. Chen,, C. M. Rodenburg,, S. F. Michael,, L. B. Cummins,, L. O. Arthur,, M. Peeters,, G. M. Shaw,, P. M. Sharp,, and B. H. Hahn. 1999. Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes. Nature 397: 436 441.
13. Groth, C. G.,, O. Korsgren,, A. Tibell,, J. Tollemar,, E. Moller,, J. Bolinder,, J. Ostman,, F. P. Reinholt,, C. Hellerstrom,, and A. Andersson. 1994. Transplantation of porcine fetal pancreas to diabetic patients. Lancet 344: 1402 1404.
14. Hardy, W. D., 1993. Feline oncoretroviruses, p. 109 180. In J. A. Levy (ed.), The Retroviridae, vol. 2. Plenum Press, New York, N.Y.
15. Heneine, W.,, W. M. Switzer,, P. Sandstrom,, J. Brown,, S. Vedapuri,, C. A. Schable,, A. S. Khan,, N. W. Lerche,, M. Schweizer,, D. Neumann-Haefelin,, L. E. Chapman,, and T. M. Folks. 1998. Identification of a human population infected with simian foamy viruses. Nature Med. 4: 403 407.
16. Heneine, W.,, A. Tibell,, W. M. Switzer,, P. Sandstrom,, G. V. Rosales,, A. Mathews,, O. Korsgren,, L. E. Chapman,, T. M. Folks,, and C. G. Groth. 1998. No evidence of infection with porcine endogenous retrovirus in recipients of porcine islet-cell xenografts. Lancet 352: 695 699.
17. Hitchcock, C. R.,, J. C. Kiser,, R. L. Telander,, and E. L. Seljeskog. 1964. Baboon renal grafts. JAMA 189: 158 161.
18. Isacson, O.,, and X. O. Breakefleld. 1997. Benefits and risks of hosting animal cells in the human brain. Nature Med. 3: 964 969.
19. Khabbaz, R. F.,, W. Heneine,, J. R. George,, B. Parekh,, T. Woods,, W. M. Switzer,, H. M. McClure,, M. Murphey-Corb,, and T. M. Folks. 1994. Brief report: infection of a laboratory worker with simian immunodeficieny virus. N. Engl. J. Med. 330: 172 177.
20. Kozak, C. A.,, and S. Ruscetti,. 1992. Retroviruses in rodents, p. 405 481. In J.A. Levy (ed.), The Retroviridae, vol. 1. Plenum Press, New York, N.Y.
21. Kroneman, A.,, L. A. H. M. Cornelissen,, M. C. Horzinek,, R. J. de Groot,, and H. F. Egberink. 1998. Identification and characterization of a porcine torovirus. J. Virol. 72: 3507 3511.
22. Le Ussier, P.,, J. P. Stoye,, Y. Takeuchi,, C. Patience,, and R. A. Weiss. 1997. Two sets of human-tropic pig retrovirus. Nature 389: 681 682.
23. Lieber, M. M.,, C. J. Sherr,, G. J. Torado,, R. E. Benveniste,, R. Callahan,, and H. G. Coon. 1975. Isolation from the Asian mouse Mus caroli of an endogenous type C virus related to infectious primate type C viruses. Proc. Natl. Acad. Sci. USA 72: 2315 2319.
24. Martin, J.,, E. Herniou,, J. Cook,, R. W. O'Neill,, and M. Tristem. 1999. Interclass transmission and phyletic host tracking in murine leukemia virus-related retroviruses. J. Virol. 73: 2442 2449.
25. McAllister, R. M.,, M. Nicolson,, M. B. Gardner,, R. W. Rongey,, S. Rasheed,, P. S. Sarma,, R. J. Huebner,, M. Hatanaka,, S. Oroszlan,, R. V. Gilden,, A. Kabigting,, and L. Vernon. 1972. C-type virus released from cultured human rhabdomyosarcoma cells. Nature New Biol. 235: 3 6.
26. Meng, X.-J.,, R. H. Purcell,, P. G. Halbur,, J. R. Lehman,, D. M. Webb,, T. S. Tsareva,, J. S. Haynes,, B.J. Tbacker,, and S. U. Emerson. 1997. A novel virus in swine is closely related to the human hepatitis E virus. Proc. Natl. Acad. Sci. USA 94: 9860 9865.
27. Michaels, M. G. 1997. Infectious concerns of cross-species transplantation: xenozoonoses. World J. Surg. 21: 968 974.
28. Onions, D.,, D. Hart,, C. Mahoney,, D. Galbraith,, and K. Smith. 1998. Endogenous retroviruses and the safety of porcine xenotransplantation. Trends Microbiol. 6: 430 431.
29. Paradis, K.,, G. Langford,, Z. Long,, W. Heneine,, P. Sandstrom,, W. M. Switzer,, L. E. Chapman,, C. Lockey,, D. Onions, the XEN 111 Study Group, and E. Otto. 1999. Search for cross-species transmission of porcine endogenous retrovirus in patients treated with living pig tissue. Science 285: 1236 1241.
30. Patience, C.,, G. S. Patton,, Y. Takeuchi,, R. A. Weiss,, M. O. McClure,, L. Rydberg,, and M. E. Breimer. 1998. No evidence of pig DNA or retroviral infection in patients with short-term extracorporeal connection to pig kidneys. Lancer 352: 699 701.
31. Patience, C.,, Y. Takeuchi,, and R. A. Weiss. 1997. Infection of human cells by an endogenous retrovirus of pigs. Nature Med. 3: 282 286.
32. Patience, C.,, Y. Takeuchi,, and R. A. Weiss. 1998. Zoonosis in xenotransplantation. Curr. Opin. Immunol. 10: 539 542.
33. Piatt, J. L. 1994. A perspective on xenograft rejection and accomodation. Immunol. Rev. 141: 127 149.
34. Piatt, J. L. 1998. New directions for organ transplantation. Nature 392: 11 17.
35. Reemtsma, K.,, B. H. McCracken,, J. U. Schlegel,, M. A. Pearl,, C. W. Pearce,, C. W. DeWitt,, P. E. Smith,, R. L. Hewitt,, R. L. Flinner,, and O. Creech, Jr. 1964. Renal heterotransplantation in man. Ann. Surg. 160: 384 410.
36. Rosenberg, N.,, and P. Jolicoeur,. 1997. Retroviral pathogenesis, p. 475 585. In J. M. Coffin,, S. H. Hughes,, and H. E. Varmus (ed.), Retroviruses. Cold Spring Harbor Press, Cold Spring Harbor, N.Y.
37. Schweizer, M.,, V. Falcone,, J. Gange,, R. Turek,, and D. Neumann-Haefelin. 1997. Simian foamy virus isolated from an accidentally infected human individual. J. Virol. 71: 4821 4824.
38. Starzl, T. E.,, J. Fung,, A. Tzakis,, S. Todo,, A. J. Demetris,, I. R. Marino,, H. Doyle,, A. Zeevi,, V. Warty,, M. Michaels,, S. Kusne,, W. A. Rudert,, and M. Trucco. 1993. Baboon-to-human liver transplantation. Lancet 341: 65 71.
39. Starzl, T. E.,, T. L. Marchioro,, G. N. Peters,, C. H. Kirkpatrick,, W. E. C. Wilson,, K. A. Porter,, D. Rifkind,, D. A. Ogden,, C. R. Hitchcock,, and W. R. Waddell. 1964. Renal heterotransplantation from baboon to man: experience with 6 cases. Transplantation 2: 752 776.
40. Starzl, T. E.,, A. Tzakis,, J. J. Fung,, S. Todo,, A. J. Demetris,, R. Manez,, I. R. Marino,, L. Valdivia,, and N. Murase. 1994. Prospects of clinical xenotransplantation. Transplant. Proc. 26: 1082.
41. Stoye, J. P.,, C. Moroni,, and J. M. Coffin. 1991. Virological events leading to spontaneous AKR thymomas. J. Virol. 65: 1273 1285.
42. Takeuchi, Y.,, C. Patience,, S. Magre,, R. A. Weiss,, P. T. Banerjee,, P. Le Tissier,, and J. P. Stoye. 1998. Host range and interference studies of three classes of pig endogenous retrovirus. J. Virol. 72: 9986 9991.
43. Temin, H. M. 1980. Origin of retroviruses from cellular moveable genetic elements. Cell 21: 599 600.
44. Temin, H. M., 1992. Origin and general nature of retroviruses, p. 1 18. In J. A. Levy (ed.), The Retroviridae, vol. 1. Plenum Press, New York, N.Y.
45. Tralka, T. S.,, C. L. Yee,, A. B. Rabson,, N. A. Wivel,, K. J. Stromberg,, A. S. Rabson,, and J. C. Costa. 1983. Murine type C retroviruses and intracisternal A-particles in human tumors serially passaged in nude mice. J. Natl. Cancer Inst. 71: 591 596.
46. van der Kuyl, A. C.,, J. T. Dekker,, and J. Goudsmit. 1996. Baboon endogenous virus evolution and ecology. Trends Microbiol. 4: 55 59.
47. van der Kuyl, A. C.,, J. T. Dekker,, and J. Goudsmit. 1995. Full-length proviruses of baboon endogenous virus (BaEV) and dispersed reverse transcriptase retroelements in the genome of baboon species. J. Virol. 69: 5917 5924.
48. Weiss, R. A. 1978. Why cell biologists should be aware of genetically transmitted viruses. Natl. Cancer Inst. Monogr. 48: 183 189.
49. Weiss, R. A. 1999. Xenografts and retroviruses. Science 285: 1221 1222.
50. Wilkinson, D. A.,, D. L. Mager,, and J. A. C. Leong,. 1994. Endogenous human retroviruses, p. 465 535. In J. A. Levy (ed.), The Retroviridae, vol. 3. Plenum Press, New York, N.Y.
51. Wilson, C. A.,, S. Wong,, J. Muller,, C. E. Davidson,, T. M. Rose, and R Burd. 1998. Type C retrovirus released from porcine primary peripheral blood mononuclear cells infects human cells. J. Virol. 72: 3082 3087.
52. Zhu, T.,, B. T. Korber,, A. J. Nahmias,, E. Hooper,, P. M. Sharp,, and D. D. Ho. 1998. An African HIV-1 sequence from 1959 and implications for the origin of the epidemic. Nature 391: 594 597.


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Table 1

Summary of characteristics of different types of endogenous retroviruses

Citation: Abu-Nader R, Paya C. 2001. Potential Medical Impact of Endogenous Retroviruses, p 251-259. In Platt J (ed), Xenotransplantation. ASM Press, Washington, DC. doi: 10.1128/9781555818043.ch14

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