Chapter 12 : Discovering What You Do and Don't Want

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Michael A. Pfaller continued to pursue applied research in terms of evaluation of in vitro test systems in the clinical laboratory. In addition, the drug-bug work continued with evaluation of new antifungal agents and antibacterial agents. The topic of antimicrobial resistance became very popular in the 1990s, and the author's microbiology group at Iowa has been in the thick of this field of investigation. The close collaboration between clinical microbiology and hospital epidemiology is one that should be sought out by all concerned. From the perspective of the clinical microbiology laboratory, one can become involved in all of the most interesting infectious disease cases. Problems in diagnosis and control of infectious diseases provide a never-ending array of material for investigation and publication. Applied research in this area invariably leads to improvements in how the clinical laboratory can serve its clients and, in many cases, can serve as a springboard to more basic investigation.

Citation: Atlas R. 2000. Discovering What You Do and Don't Want, p 88-93. In Many Faces, Many Microbes. ASM Press, Washington, DC. doi: 10.1128/9781555818128.ch12
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Citation: Atlas R. 2000. Discovering What You Do and Don't Want, p 88-93. In Many Faces, Many Microbes. ASM Press, Washington, DC. doi: 10.1128/9781555818128.ch12
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1. Jones, R. N.,, D. M. Johnson,, M. E. Erwin,, M. L. Beach,, D. J. Biedenbach,, and M. A. Pfaller. 1999. Comparative antimicrobial activity of gatifloxacin tested against Streptococcus spp. including quality control guidelines and etest method validation. Quality Control Study Group. Diagn. Microbiol. Infect. Dis. 34: 91 98.
2. Pfaller, M. A.,, R. N. Jones,, G. V. Doern,, H. S. Sader,, K. C. Kugler,, and M. L. Beach. 1999. Survey of bloodstream infections attributable to gram-positive cocci: Frequency of occurrence and antimicrobial susceptibility of isolates collected in 1997 in the United States, Canada, and Latin America from the SENTRY Antimicrobial Surveillance Program. Diagn. Microbiol. Infect. Dis. 33: 283 297.
3. Seguin, J. C.,, R. D. Walker,, J. P. Caron,, W. E. Kloos,, C. G. George,, R. J. Hollis,, R. N. Jones,, and M. A. Pfaller. 1999. Methicillin-resistant Staphylococcus aureus outbreak in a veterinary teaching hospital: Potential human-to-animal transmission. J. Clin. Microbiol. 37: 1459 1463.
4. Pfaller, M. A.,, J. Zhang,, S. A. Messer,, M. E. Brandt,, R. A. Hajjeh,, C. J. Jessup,, M. Tumberland,, E. K. Mbidde,, and M. A. Ghannoum. 1999. In vitro activities of voriconazole, fluconazole, and itraconazole against 566 clinical isolates of Cryptococcus neoformans from the United States and Africa. Antimicrob. Agents Chemother. 43: 169 171.
5. Klepser, M. E.,, R. E. Lewis,, and M. A. Pfaller. 1998. Therapy of Candida infections: Susceptibility testing, resistance, and therapeutic options. Ann. Pharmacother. 32: 1353 1361.
6. Wendt, C.,, S. A. Messer,, R. J. Hollis,, M. A. Pfaller,, and L. A. Herwaldt. 1998. Epidemiology of polyclonal gram-negative bacteremia. Diagn. Microbiol. Infect. Dis. 32: 9 13.
7. Pfaller, M. A.,, S. R. Lockhart,, C. Pujol,, J. A. Swails-Wenger,, S. A. Messer,, M. B. Edmond,, R. N. Jones,, R. P. Wenze,, and D. R. Soli. 1998. Hospital specificity, region specificity, and fluconazole resistance of Candida albicans bloodstream isolates. J. Clin. Microbiol. 36: 1518 1529.
8. Jones, R. N.,, and M. A. Pfaller. 1998. Bacterial resistance: A worldwide problem. Diagn. Microbiol. Infect. Dis. 31: 379 388.
9. Wasilauskas, B.,, R. Gay,, P. Zwadyk,, M. Pfaller,, and F. Koontz. 1987. Multicenter comparison of MicroScan and BACTEC blood culture systems. J. Clin. Microbiol. 25: 2355 2358.
10. Pfaller, M.,, B. Ringenberg,, L. Rames,, J. Hegeman,, and F. Koontz. 1987. The usefulness of screening tests for pyuria in combination with culture in the diagnosis of urinary tract infection. Diagn. Microbiol. Infect. Dis. 6: 207 215.

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