Chapter 14 : Evolution of a Clinical Microbiologist

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In this chapter the author talks about her doctoral research that involved studying interactions of with phagocytes in vitro. The aim of this work was to study the cellular immune response to salmonellae, first by using mouse cells and then moving on to a human system. At that time, knowledge of the intricacies and complexities of the immune system was rudimentary, and the author's work did not clarify the inconsistencies already present in the literature regarding the intracellular fate of microorganisms. Early on, several clinical microbiologists began to assess critically microbiological procedures that either were already in place or coming into use. They also championed the publication of journals and manuals specifically devoted to this discipline. The areas in which the author was especially interested were blood culture instruments and automated and nonautomated rapid identification systems, especially for blood culture isolates and anaerobes. These types of studies were important for determining which systems were accurate, cost-effective, and easily integrated into the work flow of the laboratory. Clearly, the field of clinical microbiology is undergoing changes that could not have been foreseen when the author first entered it. The author expects that like the forerunners who were active in the early days of her career, the new generation of clinical microbiologists will find ways to meet the challenges and bring further regard and advancement to this discipline.

Citation: Morello J. 2000. Evolution of a Clinical Microbiologist, p 101-106. In Atlas R (ed), Many Faces, Many Microbes. ASM Press, Washington, DC. doi: 10.1128/9781555818128.ch14
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Citation: Morello J. 2000. Evolution of a Clinical Microbiologist, p 101-106. In Atlas R (ed), Many Faces, Many Microbes. ASM Press, Washington, DC. doi: 10.1128/9781555818128.ch14
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1. Morello, J. A. 1999. Clinical Microbiology Reviews: Genesis of a journal. Clin. Microbiol. Rev. 12: 183 186.
2. Morello, J. A.,, C. Leitch,, S. Nitz,, J. W. Dyke,, M. Andruszewski,, G. Maier,, W. Landau,, and M. A. Beard. 1994. Bacteremia detection by the ESP blood culture system. J. Clin. Microbiol. 32: 811 818.
3. Morello, J. A.,, S. M. Matushek,, W. M. Dunne,, and D. B. Hinds. 1991 Performance of a BACTEC nonradiometric medium for pediatric blood cultures. J. Clin. Microbiol. 29: 359 362.
4. Sahm, D.,, S. Boonlayangoor,, and J. A. Morello. 1987. Direct susceptibility testing of blood culture isolates with the AutoMicrobic System (AMS). Diagn. Microbiol. Infect. Dis. 8: 1 11.
5. Janda, W. M.,, J. A. Morello,, S. A. Lerner,, and M. Bohnhoff. 1983. Characteristics of pathogenic Neisseria spp. isolated from homosexual men. J. Clin. Microbiol. 17: 85 91.
6. Morello, J. A.,, S. A. Lerner,, and M. Bohnhoff. 1976. Characteristics of atypical Neisseria gonorrhoeae from disseminated and localized infections. Infect. Immun. 13: 1510 1516.
7. Morello, J. A.,, and P. D. Ellner. 1969. New medium for blood cultures. Appl. Microbiol. 17: 68 70.
8. Morello, J. A.,, and E. E. Baker. 1965. Interaction of Salmonella with phagocytes in vitro. J. Infect. Dis. 115: 131 141.
9. Morello, J. A.,, T. A. DiGenio,, and E. E. Baker. 1964. Evaluation of serological and cultural methods for the diagnosis of chronic salmonellosis in mice J. Bacteriol. 88: 1277 1282.

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