Chapter 30 : Moving Ahead with Pseudomonad Genes

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At the University of Illinois the author quickly moved to his work in Dr. Gunsalus' laboratory on the isolation and characterization of transducing phages for . Dr. Gunsalus-known as Gunny-was extremely interested in knowing how and why exhibited a broad degradative capability. During his postdoctoral years, the author and Dr. Gunsalus came up with some very exciting observations in rapid succession, which showed that in , the genes for the degradation of rather exotic organic compounds-such as camphor, octane, and naphthalene-occur on plasmids. The researchers had made a significant advance in their basic understanding about the genes involved in the biodegradation of exotic compounds, one that also would have significant practical implications. There are natural substrates in soil, such as lignocellulosic materials, that are often preferred by the organisms rather than the toxic chemicals, whose effective concentrations, such as that of 2,3,7,8-tetrachloro-dibenzo-p-dioxin, might be extremely low to be of meaningful nutritional value to the organisms. Such mechanisms, observed first in , appear to be universal and may contribute to one's understanding of how other pathogens take over the host cell machinery.

Citation: Chakrabarty A. 2000. Moving Ahead with Pseudomonad Genes, p 235-242. In Atlas R (ed), Many Faces, Many Microbes. ASM Press, Washington, DC. doi: 10.1128/9781555818128.ch30
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Citation: Chakrabarty A. 2000. Moving Ahead with Pseudomonad Genes, p 235-242. In Atlas R (ed), Many Faces, Many Microbes. ASM Press, Washington, DC. doi: 10.1128/9781555818128.ch30
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1. Zaborina, O.,, X. Li,, G. Cheng,, V. Kapatral,, and A. M. Chakrabarty. 1999. Secretion of ATP-utilizing enzymes, nucleoside diphosphate kinase and ATPase, by Mycobacterium bovis BCG: Sequestration of ATP from macrophage P2Z receptors? Mol. Microbiol. 31: 1333 1343.
2. McFall, S. M.,, S. A. Chugani,, and A. M. Chakrabarty. 1998. Transcriptional activation of the catechol and chlorocatechol operons: Variations on a theme. Gene 223: 257 267.
3. Chakrabarty, A. M. 1998. Diamond v. Chakrabarty: A historical perspective. In D. S. Chisum,, C. A. Nard,, H. F. Schwartz,, P. Newman,, and F. S. Kieff, (ed.), Principles of Patent Law. Foundation Press, New York, N.Y..
4. Chakrabarty, A. M. 1996. Microbial degradation of toxic chemicals: Evolutionary insights and practical considerations. ASM News 62: 130 137.
5. Chakrabarty, A. M. 1982. Plasmids and nutritional diversity. In L. N. Orn-ston, and S. G. Sligar (ed.), Experiences in Biochemical Perception. Academic Press, New York, N.Y..
6. Chakrabarty, A. M. 1976. Plasmids in Pseudomonas. Annu. Rev. Genet. 10: 7 21.
7. May, T. B.,, D. Shinabarger,, R. Maharaj,, J. Kato,, L. Chu,, J. D. DeVault,, S. R. Choudhury,, N. Zielinski,, A. Berry,, R. K. Rothmel,, T. K. Misra,, and A. M. Chakrabarty. 1991. Alginate synthesis by Pseudomonas aeruginosa: A key pathogenic factor in chronic pulmonary infections of cystic fibrosis patients. Clin. Microbiol. Rev. 4: 191 206.

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