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Succumbing to the Mysteries of Microbiology and Immunology, Page 1 of 2
< Previous page Next page > /docserver/preview/fulltext/10.1128/9781555818128/9781555811907_Chap06-1.gif /docserver/preview/fulltext/10.1128/9781555818128/9781555811907_Chap06-2.gifAbstract:
Researchers determined which cytokines induced the two activated antimicrobial macrophage effector reactions-resistance to infection and intracellular killing-and which cytokines shut down the killing. The author made inroads in the understanding of Francisella infections, devised a polymerase chain reaction-based detection system and an attenuated and subunit vaccine, and explored the use of immunomodulation with bacille-Calmette-Guerin (BCG) with great success. In this chapter the author seeks additional philanthropic funds to assist companies and academic investigators in the clinical development of new anti-TB drugs. The path is set for the foundation, and there is great excitement both within the foundation and the research community. Sequella, Inc., is working with investigators in universities around the world and has licensed some innovative, useful products for diagnosis and treatment of tuberculosis (TB). It is currently raising money to fund the development of its products and hopes to have at least one of its new TB products in the marketplace by the year 2001.