Chapter 10 : Future Directions of Chlamydial Research

MyBook is a cheap paperback edition of the original book and will be sold at uniform, low price.

Preview this chapter:
Zoom in

Future Directions of Chlamydial Research, Page 1 of 2

| /docserver/preview/fulltext/10.1128/9781555818203/9781555811556_Chap10-1.gif /docserver/preview/fulltext/10.1128/9781555818203/9781555811556_Chap10-2.gif


The ultimate goals of infectious disease research are to prevent infection, morbidity, and mortality. The spectrum of chronic diseases linked to chlamydial infection falls into two broad categories: (i) those for which the evidence for causality is considered conclusive and (ii) those for which the evidence is insufficient to be considered causal. Whether chronic chlamydial infections can be "cured" with appropriate antibiotic therapy is one of the critical research questions facing the medical community. Intensive preclinical and clinical investigations are under way to develop topical microbicides that will prevent chlamydial infection as well as other sexually transmitted infections, including HIV infection. Chronic chlamydial infection in the upper reproductive tract, or pelvic inflammatory disease (PID), is one of the most serious consequences of this sexually transmitted disease for women. There is an urgent need for rapid, inexpensive, easy-to-use diagnostic tests for chlamydial infection. Data from human and veterinary studies suggest that chlamydial infections probably play an important role in pregnancy outcomes. The potential for chlamydial species to precipitate spontaneous abortion is suggested by manifestations of infection in sheep. Psittacosis has long been recognized as a systemic disease. The infectious agent gains entry through a mucosal surface and disseminates widely. Recent studies of brain tissue from patients with late-onset Alzheimer's disease have resulted in startling findings. Investigators have identified chlamydial nucleic acid sequences in disease plaques from 17 of 19 patients with late-onset Alzheimer's disease; two of these tissue samples also contained viable elementary bodies.

Citation: Hitchcock P. 1999. Future Directions of Chlamydial Research, p 297-311. In Stephens R (ed), Chlamydia. ASM Press, Washington, DC. doi: 10.1128/9781555818203.ch10
Highlighted Text: Show | Hide
Loading full text...

Full text loading...


1. Austin, H.,, W. C. Louv,, and W. J. Alexander. 1984. A case-controlled study of spermicides and gonorrhea. JAMA 251: 2822 2824.
2. Bachmaier, K.,, N. Neu,, L. M. de la Maza,, S. Pal,, A. Hessel,, and J. M. Penninger 1999. Chlamydia infections and heart disease linked through antigenic mimicry. Science 283: 1335 1339.
3. Balin, B. J.,, H. C. Gerard,, E. J. Arking,, D. M. Appelt,, P. J. Branigan,, J. T. Abrams,, J. A. Whittum-Hudson,, and A. P. Hudson. 1998. Identification and localization of Chlamydia pneumoniae in the Alzheimer's brain. Med. Microbiol. Immunol. 187: 23 42.
4. Cotch, M. F.,, J. G. Pastorek II,, R. P. Nugent,, S. L. Hillier,, R. S. Gibbs,, D. H. Martin,, D. A. Eschenbach,, R. Edelman,, J. C. Carey,, J. A. Regan,, M. A. Krohn,, M. A. Klebanoff,, A. V. Rao,, and G. G. Rhoads. 1997. Trichomonas vaginalis associated with low birth weight and preterm delivery. The Vaginal Infections and Prematurity Study Group. Sex. Transm. Dis. 24: 353 360.
5. Jones, G. E., 1999. Chlamydial diseases of the reproductive tract of domestic ruminants, p. 293 309. In P. J. Hitchcock,, H. T. MacKay,, J. N. Wasserheit,, and R. Binder (ed.), Sexually Transmitted Diseases and Adverse Outcomes of Pregnancy. ASM Press, Washington, D.C..
6. Pacheco, A.,, J. Gonzalez-Sainz,, C. Arocena,, M. Rebollar,, A. Antela,, and A. Guerrero. 1991. Community acquired pneumonia caused by Chlamydia pneumoniae strain TWAR in chronic cardio-pulmonary disease in the elderly. Respiration 58: 316 320.
7. Roddy, R. E.,, L. Zekeng,, K. A. Ryan,, U. Tamouf,, S. S. Weir,, and E. L. Wong. 1998. A controlled trial of nonoxynol-9 film to reduce male-to-female transmission of sexually transmitted diseases. N. Engl. J. Med. 339: 504 510.
8. Shain, R. N.,, J. M. Piper,, E. R. Newton,, S. T. Perdue,, R. Ramos,, J. D. Champion,, and F. A. Guerra. 1999. A randomized, controlled trial of a behavioral intervention to prevent sexually transmitted disease among minority women. N. Engl. J. Med. 340: 93 100.
9. von Hertzen, L. C. 1998. Chlamydia pneumoniae and its role in chronic obstructive pulmonary disease. Ann. Med. 30: 27 37.
10. Wasserheit, J. N. 1992. Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases. Sex. Transm. Dis. 19: 61 77.


Generic image for table
Table 1

Consequences of chronic chlamydial infections

Citation: Hitchcock P. 1999. Future Directions of Chlamydial Research, p 297-311. In Stephens R (ed), Chlamydia. ASM Press, Washington, DC. doi: 10.1128/9781555818203.ch10

This is a required field
Please enter a valid email address
Please check the format of the address you have entered.
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error