Chapter 17 : Laryngeal Papillomatosis

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This chapter briefly summarizes maternally transmitted genital human papillomavirus (HPV) infections in children and problems associated with HPV-related diseases among pregnant women near parturition. Most of the discussion focuses on juvenile-onset laryngeal papillomatosis (recurrent respiratory papillomatosis [RRP]), the most challenging and costly of the diseases associated with mother-child HPV transmission. Laryngeal papillomatosis is the most common benign neoplasm of the larynx. The lesions are characterized by recurrent tumors, which cause hoarseness and upper airway obstruction. The incidence of both juvenile-onset and adult-onset papillomatosis is unknown, and the prevalence of disease has not been accurately assessed. The various forms of therapy have included different ablative and surgical techniques, topical and oral medical therapies, interferon, and laser therapy. Most of these treatment strategies have been evaluated by means of uncontrolled trials, although a few well-designed controlled clinical trials have evaluated the effects of intramuscular interferon as an adjunct therapy for control of RRP. Congenital condylomata acuminata is a rarely reported disease of newborns and infants. Several case reports, however, clearly indicate the occurrence of maternal-fetal transmission even in the absence of fetal exposure to the maternal genital tract through cesarean delivery. Research in the field of maternal transmission of HPV to infants has been hampered by the same limitations that have slowed progress in studies of genital HPV and cervical neoplasia—inability to culture or propagate the virus and uncertain test characteristics (sensitivity and specificity) in identification of HPV infection.

Citation: Becker T. 1999. Laryngeal Papillomatosis, p 283-290. In Hitchcock P, MacKay H, Wasserheit J, Binder R (ed), Sexually Transmitted Diseases and Adverse Outcomes of Pregnancy. ASM Press, Washington, DC. doi: 10.1128/9781555818210.ch17
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1. Abramson, A. L.,, V. Mullooly,, M. S. Horowitz,, and B. M. Steinberg. 1988. Clinical effects of alpha interferon dose variation on laryngeal papillomas. Laryngoscope 98: 1324 1329.
2. Abramson, A. L.,, M. J. Shikowitz,, V. M. Mullooly,, B. M. Steinberg,, C. A. Amella,, and H. R. Rothstein. 1992. Clinical effects of photodynamic therapy on recurrent laryngeal papillomas. Arch. Otolaryngol. Head Neck Surg. 118: 25 29.
3. Apple, R. J.,, H. A. Erlich,, W. Klitz,, M. M. Manos,, T. M. Becker,, and C. M. Wheeler. 1994. HLA DR-DQ disease associations in Hispanic cervical carcinoma are HPV type-specific. Nat. Genet. 6(2): 157 162.
4. Avidano, M. A.,, and G. T. Singleton. 1995. Adjuvant drug strategies in the treatment of recurrent respiratory papillomatosis. Otolaryngol. Head Neck Surg. 112: 197 202.
5. Bauman, N.,, and R. Smith. 1996. Recurrent respiratory papillomatosis. Pediatr. Otol. 43: 1385 1401.
6. Becker, T. M.,, C. M. Wheeler,, N. S. McGough,, C. A. Parmenter,, C. A. Stidley,, M. H. Dorin,, and S. W. Jordan. 1994. Sexually transmitted diseases and other risk factors for cervical dysplasia in southwestern Hispanic and non-Hispanic white women. JAMA 271: 1181 1188.
7. Bonagura, V. R.,, F. P. Siegal,, A. L. Abramson,, F. Santiago-Schwartz,, M. E. O’Reilly,, K. Shah,, D. Drake,, and B. M. Steinberg. 1994. Enriched HLA-DQ3 phenotype and decreased class I major histocompatibility complex antigen expression in recurrent respiratory papillomatosis. Clin. Diagn. Lab. Immunol. 1: 357 360.
8. Corbitt, G.,, A. P. Zarod,, J. R. Arrand,, M. Longson,, and W. T. Farrington. 1988. Human papillomavirus genotypes associated with laryngeal papilloma. J. Clin. Pathol. 41: 284 288.
9. Dedo, H. H.,, and R. K. Jackler. 1982. Laryngeal papilloma: results of treatment with the CO 2 laser and podophyllin. Am. Otol. Rhinol. Laryngol. 91: 425 430.
10. Healy, G. B.,, R. D. Gelber,, A. L. Trowbridge,, K. M. Grundfast,, R. J. Ruben,, and K. N. Price. 1988. Treatment of recurrent respiratory papillomatosis with human leukocyte interferon. N. Engl. J. Med. 319: 401 407.
11. Holinger, P. H.,, K. C. Johnston,, and G. C. Anison. 1950. Papilloma of the larynx: a review of 109 cases with a preliminary report of aureomycin therapy . Ann. Otol. Rhinol. Laryngol. 59: 547 559.
12. Kashima, H. K.,, K. Shah,, and M. Goodstein,. 1990. Recurrent respiratory papillomatosis, p. 889 893. In K. K. Holmes,, P.-A. Mardh,, F. Sparling,, and P. Weisner (ed.), Sexually Transmitted Diseases. McGraw-Hill Book Co., New York, N.Y.
13. Kashima, H.,, F. Shah,, A. Lyles,, R. Glackin,, N. Muhammad,, L. Turner,, S. Van Zandt,, W. Whitt,, and K. Shah. 1992. A comparison of risk factors in juvenile onset and adult onset recurrent respiratory papillomatosis. Laryngoscope 102: 9 13.
14. Leventhal, B. G.,, H. K. Kashima,, P. W. Weck,, P. Mounts,, J. K. Whisnant,, K. L. Clark,, S. Cohen,, H. H. Dedo,, D. J. Donovan,, B. W. Fearon,, L. J. Gardiner,, R. P. Lusk,, H. R. Muntz,, M. A. Richardson,, G. T. Singleton,, A. S. Yonkers,, and D. Wold. 1988. Randomized surgical adjuvant trial of interferon alpha-n1 in recurrent papillomatosis. Arch. Otolaryngol. Head Neck Surg. 114: 1163 1169.
15. Leventhal, B. G.,, H. K. Kashima,, P. Mounts,, L. Thurmond,, S. Chapman,, S. Buckley,, and D. Wold. 1991. Long-term response of recurrent respiratory papillomatosis to treatment with lymphoblastoid interferon alfa-n1. N. Engl. J. Med. 325: 613 617.
16. McCabe, B. F.,, and K. F. Clark. 1983. Interferon and laryngeal papillomatosis: the Iowa experience. Ann. Otol. Laryngol. 92: 2 7.
17. Mounts, P.,, and H. Kashima. 1984. Association of human papillomavirus subtype and clinical course in respiratory papillomatosis. Laryngoscope 94: 28 32.
18. Mounts, P.,, K. Shah,, and H. Kashima. 1982. Viral etiology of juvenile and adult onset squamous papilloma of the larynx. Proc. Natl. Acad. Sci. USA 79: 5425 5429.
19. Munoz, N.,, and F. X. Bosch,. 1992. Review of case-control and cohort studies, p. 251 260. In N. Munoz,, F. X. Bosch,, K. Shah,, and A. Meheus (ed.), The Epidemiology of Cervical Cancer and Human Papillomavirus. IARC, Lyon, France.
20. Pou, A. M.,, F. L. Rimell,, J. A. Jordan,, P. Barua,, D. L. Shoemaker,, J. C. Post,, J. T. Johnson,, and G. D. Ehrlich. 1995. Adult respiratory papillomatosis: human papillomavirus type and viral coinfections as predictors of prognosis. Ann. Otol. Rhinol. Laryngol. 104: 758 762.
21. Quick, C. A.,, S. L. Watts,, R. A. Krzyzek,, and A. J. Faras. 1980. Relationship between condylomata and laryngeal papillomata. Ann. Otol. 89: 467 471.
22. Rogo, K. O.,, and P. N. Nyansera. 1989. Congenital condylomata acuminata with meconium staining of amniotic fluid and fetal hydrocephalus: case report. East Afr. Med. J. 66: 411 413.
23. Smith, H. G.,, C. W. Vaughan,, G. B. Healy,, and M. S. Strong. 1980. Topical chemotherapy of recurrent respiratory papillomatosis. Ann. Otol. 89: 473 478.
24. Steinberg, B. M.,, and A. L. Abramson. 1985. Laryngeal papillomas. Clin. Dermatol. 3: 130 138.
25. Steinberg, B. M.,, A. L. Abramson,, and B. Winkler. 1987. Laryngeal papillomatosis: clinical, histopathologic, and molecular studies. Laryngoscope 97: 678 685.
26. Steinberg, B. M.,, T. Gallagher,, M. Stotler,, and A. L. Abramson. 1998. Persistence and expression of human papillomavirus during interferon therapy. Arch. Otolaryngol. Head Neck Surg. 114: 27 32.
27. Tang, C.,, D. W. Shermeta,, and C. Wood. 1978. Congenital condylomata acuminata. Am. J. Obstet. Gynecol. 131: 912 913.
28. Wank, R.,, and C. Thomssen. 1991. High risk of squamous cell carcinoma of the cervix for women with HLA-DQw3. Nature 352: 723 725.
29. Weiss, J. P.,, S. November,, and C. T. Curtin. 1986. Recurrent penile condylomata in a 17-month old boy. J. Urol. 136: 468 469.

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