Chapter 10 : Animal Models and Veterinary Aspects of Cryptococcosis

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has been reported to cause infection in a wide variety of mammalian hosts. The clinical history of both natural and experimental animal cryptococcosis began over 100 years ago with the initial description of the pathogenic yeast. It was at this time in the late 19th century that experimental animal models of cryptococcosis were first used. Several pathological findings in this study were of further interest. Mice are extremely attractive for the study of cryptococcosis for two very important reasons. First, they provide both a very uniform set of immune responses and a wide variety of these responses in a series of inbred strains. The second reason that mice are attractive for the study of cryptococcosis is the ability to immunologically alter them, either genetically or through immunological reagents. Mouse models have also been used to dissect the importance of specific cell-mediated immunity in cryptococcosis. The rabbit is an interesting model for the study of cryptococcosis and has both positive and negative features for the study of cryptococcal pathogenesis. Although much of the discussion on animal model systems has emphasized the four major models, has also been inoculated into other animals.

Citation: Casadevall A, Perfect J. 1998. Animal Models and Veterinary Aspects of Cryptococcosis, p 325-350. In . ASM Press, Washington, DC. doi: 10.1128/9781555818241.ch10
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Table 1

Cryptococcosis in mammals (natural infection)

Citation: Casadevall A, Perfect J. 1998. Animal Models and Veterinary Aspects of Cryptococcosis, p 325-350. In . ASM Press, Washington, DC. doi: 10.1128/9781555818241.ch10
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Table 2

Animal model characteristics for cryptococcosis of the four major species

Abbreviations: MNCs, mononuclear cells; NK, natural killer cells; PMNs, polymorphonuclear cells.

There are numerous references in the literature in which a variety of mouse strains were used, from outbred Swiss mice to a series of inbred strains.

Citation: Casadevall A, Perfect J. 1998. Animal Models and Veterinary Aspects of Cryptococcosis, p 325-350. In . ASM Press, Washington, DC. doi: 10.1128/9781555818241.ch10
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Table 3

Advantages and disadvantages of the primary animal models for cryptococosis

Citation: Casadevall A, Perfect J. 1998. Animal Models and Veterinary Aspects of Cryptococcosis, p 325-350. In . ASM Press, Washington, DC. doi: 10.1128/9781555818241.ch10

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