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Chapter 1 : Historical Perspective

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Abstract:

Mutations in either or of resulted in the same phenotype: the inability to grow on many carbon compounds other than glucose. The contributions of the products of the two genes could be distinguished by the observation that the growth defect of the mutants but not that of the mutants could be corrected by the addition of cyclic AMP (cAMP) to the growth medium, indicating that these mutants lack the enzyme necessary for the synthesis of cAMP. The inducible phenotype of the wild-type strain depends on the normal function of two genes, , the structural gene for the repressor, and , the structural gene for urocanase, the enzyme responsible for the degradation of urocanate, the product of histidase. The important characteristic of two-component systems is therefore the covalent modification of the effector by the modulator. Apparently, the domains of the proteins evolved independently and were then combined. It is likely that effectors dependent on phosphorylation by phosphodonors of low molecular weight existed before the evolution of specific modulators.

Citation: Magasanik B. 1995. Historical Perspective, p 1-5. In Hoch J, Silhavy T (ed), Two-Component Signal Transduction. ASM Press, Washington, DC. doi: 10.1128/9781555818319.ch1
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References

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1. Adler, S. R.,, D. Purich,, and E. R. Stadtman. 1975. Cascade control of Escherichia coli glutamine synthetase. Properties of the P II regulatory protein and the uridylyltransferase-uridylyl removing enzyme. J. Biol. Chem. 250: 6264 6272.
2. Albright, L. M.,, E. Huala, and E M. Ausubel. 1989. Prokaryotic signal transduction mediated by sensor and regulator protein pairs. Annu. Rev. Genet. 23: 311 336.
3. Bueno, R.,, G. Pahel,, and B. Magasanik. 1985. Role of glnB and glnD gene products in regulation of the glnALG operon of Escherichia coli. J. Bacteriol. 164: 816 822.
4. Chang, C.,, S. E. Krook,, A. B. Bleecker,, and E. M. Meyerowitz. 1993. Arabidopsis ethylene response gene ETR11: Similarity of product to two-component regulators. Science 262: 539 544.
5. Feng, J.,, M. R. Atkinson,, W. McCleary,, J. B. Stock,, B. L. Wanner,, and A. J. Ninfa. 1992. Role of phosphorylated metabolic intermediates in the regulation of glutamine synthetase synthesis in Escherichia coli. J. Bacteriol. 174: 6061 6070.
6. Hagen, D. C.,, and B. Magasanik. 1973. Isolation of the self-regulated repressor protein of the hut operons of Salmonella typhimurium. Proc. Natl. Acad. Sci. USA 70: 808 812.
7. Hirschman, J.,, P.-K. Wong,, K. Sei,, J. Keener,, and S. Kustu. 1985. Products of nitrogen regulatory genes ntrA and ntrC of enteric bacteria activate glnA transcription in vitro: evidence that the ntrA product is a sigma factor. Proc. Natl. Acad. Sci. USA 82: 7525 7529.
8. Hunt, T. P.,, and B. Magasanik. 1985. Transcription of glnA by purified Escherichia coli components: core RNA polymerase and the products of glnF glnG and glnL. Proc. Natl. Acad. Sci. USA 82: 8453 8457.
9. Lee, H.-S.,, E. Naberhaus,, and S. Kustu. 1993. In vitro activity of NifL, a signal transduction protein for biological nitrogen fixation. J. Bacteriol. 175: 7683 7688.
10. Lukat, G. S.,, W. R. McCleary,, A. M. Stock,, and J. B. Stock. 1992. Phosphorylation of bacterial response regulator proteins by low molecular weight phosphodonors. Proc. Natl. Acad. Sci. USA 89: 718 722.
11. Ninfa, A. J.,, and B. Magasanik. 1986. Covalent modification of the glnG product, NRi, by the glnL product, NRn, regulates the transcription of the glnALG operon in Escherichia coli. Proc. Natl. Acad. Sci. USA 83: 5909 5913.
12. Ninfa, A. J.,, E. B. Ninfa,, A. N. Lupas,, A. Stock,, B. Magasanik,, and J. Stock. 1988. Crosstalk between bacterial chemotaxis signal transduction proteins and regulations of transcription of the Ntr regulon: evidence that nitrogen assimilation and chemotaxis are controlled by a common phosphotransferase mechanism. Proc. Natl. Acad. Sci. USA 85: 5492 5496.
13. Nixon, B. C.,, C. W. Ronson,, and E. M. Ausubel. 1986. Two-component regulatory systems responsive to environmental stimuli share strongly conserved domains with the nitrogen assimilation regulatory genes ntrB and ntrC. Proc. Natl. Acad. Sci. USA 83: 7850 7854.
14. Ota, I. M.,, and A. Varshavsky. 1993. A yeast protein similar to two-component regulators. Science 262: 566 569.
15. Pardee, A. B.,, E. Jacob,, and J. Monod. 1959. The genetic control and cytoplasmic expression of "inducibility" in the synthesis of β-galactosidase by E. coli. J. Mol. Biol. 1: 165 178.
16. Parkinson, J. S.,, and E. C. Kofoid. 1992. Communication modules in bacterial signaling proteins. Annu. Rev. Genet. 26: 71 112.
17. Perlman, R. L.,, and I. Pastan. 1969. Pleiotropic deficiency of carbohydrate utilization in an adenylylcyclase deficient mutant of Escherichia coli. Biochem. Biophys. Res. Commun. 37: 151 157.
18. Porter, S. C.,, A. K. North,, A. B. Wedel,, and S. Kustu. 1993. Oligomerization of NTRC at the glnA enhancer is required for transcriptional activation. Genes Dev. 7: 2258 2273.
19. Reitzer, L. J.,, and B. Magasanik. 1985. Expression of glnA in Escherichia coli is regulated at tandem promoters. Proc. Natl. Acad. Sci. USA 82: 1979 1983.
20. Schlesinger, S.,, P. Scotto,, and B. Magasanik. 1965. Exogenous and endogenous induction of the histidine-degrading enzymes in Aerobacter aerogenes. J. Biol. Chem. 240: 4331 4337.
21. Stadtman, E. R.,, E. Mura,, P. B. Chock,, and S. G. Rhee,. 1980. The interconvertible enzyme cascade that regulates glutamine synthetase activity, p. 4159. In J. Mora, and R. Palacios (ed.), Glutamine: metabolism, enzymology and regulation. Academic Press, Inc., New York.
22. Stock, J. B.,, A.J. Ninfa,, and A. M. Stock. 1989. Protein phosphorylation and regulation of adaptive responses in bacteria. Microbiol. Rev. 53: 450 490.
23. Umbarger, H. E. 1956. Evidence for a negative feedback mechanism in the biosynthesis of isoleucine. Science 123: 848.
24. Wanner, B. L.,, and M. R. Riesenberg. 1992. Involvement of phosphotransacetylase, acetate kinase and acetylphosphate synthesis in control of the phosphate regulon in Escherichia coli. J. Bacteriol. 174: 2124 2130.
25. Weiss, V.,, E. Claverie-Martin,, and B. Magasanik. 1992. Phosphorylation of nitrogen regulator I (NRi) of Escherichia coli induces strong cooperative binding to DNA essential for the activation of transcription. Proc. Natl. Acad. Sci. USA 89: 5088 5092.
26. Weiss, V.,, and B. Magasanik. 1988. Phosphorylation of nitrogen regulator I (NRi) of Escherichia coli. Proc. Natl. Acad. Sci. USA 85: 8919 8923.
27. Zubay, G.,, D. Schwartz,, and J. Beckwith. 1970. Mechanism of activation of catabolite-sensitive genes: a positive control system. Proc. Natl. Acad. Sci. USA 66: 104 110.

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