Chapter 19 : Two-Component Signal Transduction and Its Role in the Expression of Bacterial Virulence Factors

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In contrast to saprophytic bacteria, pathogenic bacteria live on or within living host tissues. Pathogenic bacteria coordinate an intricate network of virulence factors, whose expression must be precisely controlled to maximize the chance of establishing a successful infection. Certain common themes have emerged from the study of the control of bacterial virulence gene expression. has adapted the OmpR-EnvZ system, initially described in and also present in spp., for its own use to regulate expression of virulence factors and the OmpF and OmpC porins. An in vivo model for bacterial arthritis has indicated that AgrA may be involved in the direct regulation of additional genes whose expression is not mediated by RNA III. Bacteria deleted for the locus were unable to migrate through blood to the joint cavities and could not be recovered from these locations. Unlike wild-type , mutant bacteria could be recovered from the spleen, and one possible explanation is that the increased expression of cell wall-associated proteins in an mutant renders it more easily phagocytosed or immobilized in the reticulo-endothelial system. PilA and PilB are believed to control the expression of other genes as well, because two-dimensional gels of mutants showed significant differences when compared with wild-type cells.

Citation: Dziejman M, Mekalanos J. 1995. Two-Component Signal Transduction and Its Role in the Expression of Bacterial Virulence Factors, p 305-317. In Hoch J, Silhavy T (ed), Two-Component Signal Transduction. ASM Press, Washington, DC. doi: 10.1128/9781555818319.ch19
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Two-component regulation of virulence

Citation: Dziejman M, Mekalanos J. 1995. Two-Component Signal Transduction and Its Role in the Expression of Bacterial Virulence Factors, p 305-317. In Hoch J, Silhavy T (ed), Two-Component Signal Transduction. ASM Press, Washington, DC. doi: 10.1128/9781555818319.ch19
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Non-two-component regulation

Citation: Dziejman M, Mekalanos J. 1995. Two-Component Signal Transduction and Its Role in the Expression of Bacterial Virulence Factors, p 305-317. In Hoch J, Silhavy T (ed), Two-Component Signal Transduction. ASM Press, Washington, DC. doi: 10.1128/9781555818319.ch19

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