tRNA: Structure, Biosynthesis, and Function

Affiliations: 1: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut; 2: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts
Content Type: Monograph
Format: Electronic
Publication Year: 1995

Category: Microbial Genetics and Molecular Biology

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The rapid progress of research in the tRNA field and recent advances in the understanding of the molecular basis of specificity in tRNA: protein interactions make it necessary to have all of the accumulated information in an easily accessible form. The purpose of this book is to fulfill that need by providing an up-to-date account of all aspects of research on transfer RNA, including its structure, biosynthesis, and interactions with the many proteins involved in protein biosynthesis.

Beginning with an historical account, the book covers a broad area of research on tRNA biosynthesis, the different functions of tRNA in the genetic decoding process, its association with many different proteins, and the emerging rules governing the specificity of their interactions. In view of the impressive progress made in the last few years, several of the chapters are devoted to discussion of aminoacyl-tRNA synthetase tRNA interactions. An appendix containing the structural formulae of all modified nucleosides found in tRNA completes this book.

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