Nontoxigenic Vibrio cholerae O1 Infections in the United States

Daniel C. Rodrigue; Tanja Popovic; I. Kaye Wachsmuth

doi:10.1128/9781555818364.ch5

Chapter 5 : Nontoxigenic Vibrio cholerae O1 Infections in the United States

Authors: Daniel C. Rodrigue¹, Tanja Popovic², I. Kaye Wachsmuth²

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Affiliations: 1: Department of Medicine, Division of Infectious Diseases, University of Southern California School of Medicine,Los Angeles, California 90033; 2: Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333

Content Type: Monograph

Publication Year: 1994

Category: Clinical Microbiology; Bacterial Pathogenesis

Book DOI: 10.1128/9781555818364

Chapter DOI: 10.1128/9781555818364.ch5

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Abstract:

During the past two decades, strains of nontoxigenic (NT) Vibrio cholerae O1 have been isolated in several countries, including Bangladesh, Guam, Brazil, Peru, Japan, England, and the United States. This chapter summarizes the available epidemiologic, microbiologic, and clinical information on NT V. cholerae O1 isolates from humans in the United States received by the Centers for Disease Control and Prevention (CDC) between 1977 and 1991. NT V. cholerae of O group 1 is biochemically and serologically indistinguishable from toxigenic V. cholerae O1, the cause of epidemic cholera, but does not produce cholera toxin (CT). The elevated levels of cyclic AMP in the mucosal cells of the small bowel cause a cascade that ultimately results in hypersecretion of chloride and bicarbonate into the intestinal lumen and hence a net osmotic efflux of water. NT V. cholerae O1 isolates were associated with a broad spectrum of illnesses. Symptoms recorded in medical records and epidemiologic reporting forms showed that 6 (43%) of 14 patients were hospitalized but that none died. Public health practitioners should regard NT V. cholerae O1 as a potential human pathogen but not as a pathogen with the same lethality and epidemic potential as toxigenic V. cholerae O1.

Citation: Rodrigue D, Popovic T, Wachsmuth I. 1994. Nontoxigenic Vibrio cholerae O1 Infections in the United States, p 69-76. In Wachsmuth I, Blake P, Olsvik Ø (ed), Vibrio cholerae and Cholera. ASM Press, Washington, DC. doi: 10.1128/9781555818364.ch5

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Nontoxigenic Vibrio cholerae O1 Infections in the United States

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Figure 1

Seasonal distribution and isolation sites of 14 NT V. cholerae O1 infections, United States, 1977 to 1991.

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Figure 1

Seasonal distribution and isolation sites of 14 NT V. cholerae O1 infections, United States, 1977 to 1991.

References

/content/book/10.1128/9781555818364.chap5

1. Almeida, R. J. 1990. Identification and differentiation of pathogenic and epidemic Vibrio cholerae O1 strains. Ph.D. dissertation. University of North Carolina, Chapel Hill.

2. Almeida, R. J.,, D. N. Cameron,, W. L. Cook,, and I. K. Wachsmuth. 1992. Vibriophage VcA-3 as an epidemic strain marker for the U.S. Gulf Coast V. cholerae O1 clone. J. Clin. Microbiol. 30: 300– 304.

3. Almeida, R. J.,, F. W. Hickman-Brenner,, E. G. Sowers,, N. D. Puhr,, J. J. Farmer III,, and I. K. Wachsmuth. 1990. Comparison of a latex agglutination assay and an enzyme-linked immunosorbent assay for detecting cholera toxin. J. Clin. Microbiol. 28: 128– 130.

4. Bhattacharya, S. K.,, M. K. Bhattacharya,, P. Dutta,, D. Dutta,, S. P. De,, S. N. Sikdar,, A. Maitra,, A. Dutta,, and S. C. Pal. 1990. Double-blind, randomized, controlled clinical trial of norfloxacin for cholera. Antimicrob. Agents Chemother. 34: 939– 940.

5. Centers for Disease Control. 1977. Vibrio cholerae—Alabama. Morbid. Mortal. Weekly Rep. 26: 159– 160.

6. Chen, E.,, G. M. Evins,, W. L. Cook,, R. Almeida,, N. Hargrett-Bean,, and I. K. Wachsmuth. 1991. Genetic diversity among toxigenic and nontoxigenic Vibro cholerae Ol isolated from the western hemisphere. Epidemiol. Infect. 107: 225– 233.

7. Colwell, R. R.,, R. J. Seidler,, J. B. Kaper,, S. W. Joseph,, S. Garges,, H. Lockman,, D. Maneval,, H. Bradford,, N. Roberts,, E. Remmers,, I. Huq,, and A. Huq. 1981. Occurrence of Vibro cholerae serotype Ol in Maryland and Louisiana estuaries. Appl. Environ. Microbiol. 41: 555– 557.

8. DiRita, V.,, C. Parsot,, G. Jander,, and J. J. Mekalanos. 1991. Regulatory cascade controls virulence in Vibrio cholerae. Proc. Natl. Acad. Sci USA 88: 5403– 5407.

9. Falkow, S.,, and J. J. Mekalanos,. 1990. The enteric bacilli and vibrios, p. 561– 587. In B. D. Davis (ed.), Microbiology, 4th ed. J. B. Lippincott Co., Philadelphia.

10. Fields, P. I.,, T. Popovic,, K. Wachsmuth, and 0. Olsvik. 1992. Use of polymerase chain reaction for detection of toxigenic Vibrio cholerae Ol strains from the Latin American cholera epidemic. J. Clin. Microbiol. 30: 2118– 2121.

11. Goldberg, S.,, and J. R. Murphy. 1983. Molecular epidemiological studies of the United States Gulf Coast Vibrio cholerae strains: integration site of mutator vibriophage VcA-3. Infect. Immun. 42: 224– 230.

12. Herrington, D. A.,, R. H. Hall,, G. Losonsky,, J. J. Mekalanos,, R. K. Taylor,, and M. M. Levine. 1988. Toxin, toxin coregulated pili, and the toxR regulon are essential for Vibrio cholerae pathogenesis in humans. J. Exp. Med. 168: 1487– 1492.

13. Honda, S. I.,, K. Shimoirisa,, and A. Adachi. 1988. Clinical isolates of Vibrio cholerae Ol not producing cholera toxin. Lancet ii: 1486.

14. Hood, M. A.,, G. E. Ness,, and G. E. Rodrick. Isolation of Vibrio cholerae serotype Ol from the eastern oyster, Crassostrea virginica. Appl. Environ. Microbiol. 41: 559– 560.

15. Johnston, J. M.,, L. M. McFarland,, H. B. Bradford,, and C. T. Caraway. 1983. Isolation of non-toxigenic Vibrio cholerae Ol from a human wound infection. J. Clin. Microbiol. 17: 918– 920.

16. Kaper, J. B. 1989. Vibrio cholerae vaccines. Rev. Infect. Dis. Suppl 3: S568– S573.

17. Kaper, J. B. 1989. Vibrio cholerae vaccines. Rev. Infect. Dis. Suppl. 3: S568– S573.

18. Kelly, M. T.,, F. W. Hickman-Brenner,, and J. J. Farmer HI,. 1991. Vibrio, p. 384– 395. In A. Ba-lows,, W. J. Hausler, Jr.,, K. L. Herrmann,, H. D. Isenberg,, and H. J. Shadomy (ed.), Manual of Clinical Microbiology, 5th ed. American Society for Microbiology, Washington, D.C.

19. Klontz, K. C.,, R. V. Tauxe,, W. L. Cook,, W. H. Riley,, and I. K. Wachsmuth. 1987. Cholera after the consumption of raw oysters. Ann. Intern. Med. 107: 846– 848.

20. Levine, M. M.,, R. E. Black,, M. L. Clements,, L. Cisneros,, A. Saah,, D. R. Nalin,, D. M. Gill,, J. P. Craig,, C. R. Young,, and P. Ristaino. 1982. The pathogenicity of nonenterotoxigenic Vibrio cholerae serogroup Ol biotype E. Tor isolated from sewage water in Brazil. J. Infect. Dis. 145: 296– 299.

21. Levine, M. M.,, J. B. Kaper,, D. Herrington,, J. Ketley,, G. Losonsky,, C. O. Tacket,, B. Tall,, and S. Cryz. 1988. Safety, immunogenicity, and the efficacy of recombinant live oral cholera vaccines, CVD 103 and CVD 103 HgR. Lancet 1: 467– 470.

22. Morris, J. G.,, and R. E. Black. 1985. Cholera and other vibrioses in the United States. N. Engl. J. Med. 312: 343– 350.

23. Morris, J. G.,, J. L. Picardi,, S. Lieb,, J. V. Lee,, A. Roberts,, M. Hood,, R. A. Gunn,, and P. A. Blake. 1984. Isolation of nontoxigenic Vibrio cholerae O group 1 from a patient with severe gastroinestinal disease. J. Clin. Microbiol. 19: 296– 297.

24. Morris, J. G., Jr.,, J. H. Tenney,, and G. L. Drusano. 1985. In vitro susceptibility of pathogenic Vibrio species to norfloxacin and six other antimicrobial agents. Antimicrob. Agents Chemother. 28: 442– 445.

25. Moyenuddin, M.,, K. Wachsmuth,, S. H. Richardson,, and W. L. Cook. 1992. Enteropatho-genicity of non-toxigenic Vibrio cholerae Ol for adult mice. Microb. Pathog. 12: 451– 458.

26. O'Brien, A. D.,, M. E. Chen,, R. K. Holmes,, J. B. Kaper,, and M. M. Levine. 1984. Environmental and human isolates Vibrio cholerae and Vibrio parahemolyticus produce a Shigella dysenteriae 1 (Shiga)-like cytotoxin. Lancet i: 77– 78.

27. Peterson, K. M.,, R. K. Taylor,, V. I. Miller,, V. J. DiRita,, and J. J. Mekalanos,. 1988. Coordinate regulation of virulence determinants in Vibrio cholerae, p. 165– 172. In M. Schwartz (ed.), Molecular biology and infectious diseases. Elsevier, Paris.

28. Popovic, T.,, C. A. Bopp,, Ø. Olsvik,, and I. K. Wachsmuth. 1993. A standardized ribotype scheme for Vibrio cholerae O1: epidemiologic application. J. Clin. Microbiol. 31: 2474– 2482.

29. Richardson, S. H.,, J. C. Giles,, and K. S. Kruger. 1984. Sealed adult mice: new model for enterotoxin evaluation. Infect. Immun. 43: 482– 486.

30. Sack, D. A.,, S. Huda,, P. K. B. Neogi,, R. R. Danial,, and W. M. Spira. 1980. Microtiter ganglioside enzyme-linked immunosorbent assay for Vibrio and Escherichia heat-labile enterotoxins and antioxin. J. Clin. Microbiol. 11: 35– 40.

31. Sack, D. A.,, and R. B. Sack. 1975. Test for enterotoxigenic Escherichia coli using Yl adrenal cells in miniculture. Infect. Immun. 11: 334– 336.

32. Safrin, S.,, J. G. Morris,, M. Adams,, V. Pons,, R. Jacobs,, and J. E. Conte, Jr. 1988. Non-O1 Vibrio cholerae bacteremia: case report and review. Rev. Infect. Dis. 10: 1012– 1017.

33. Sanyal, S. C.,, K. Alam,, P. K. B. Neogi,, M. I. Huq,, and K. A. Al-Mahmud. 1983. A new cholera toxin. Lancet i: 1337.

34. Sanyal, S. C.,, P. K. B. Neogi,, K. Alam,, H. I. Huq,, and K. A. Al-Mahmud. 1984. A new enterotoxin produced by Vibrio cholerae Ol, J. Diarrheal Dis. Res. 2: 3– 12.

35. Sigel, S. P.,, S. Lanier,, V. S. Baselski,, and C. D. Parker. 1980. In vivo evaluation of pathogenicity of clinical and environmental isolates of Vibrio cholerae. Infect. Immun. 28: 681– 687.

36. Spira, W. M.,, D. A. Sack,, P. J. Fedorka-Cray,, S. Sanyal,, J. Madden,, and B. McCardeU,. 1986. Description of a possible new extracellular virulence factor in nontoxigenic Vibrio cholerae Ol, p. 263– 270. In S. Kuwahara, and N. F. Pierce (ed.), Advances in research on cholera and related diarrheas, 3rd ed. KTK Scientific Publishers, Tokyo.

37. Wachsmuth, I. K.,, G. M. Evins,, P. I. fields,, O. Olsvik,, T. Popovic,, J. G. Wells,, C. Carrillo,, and P. A. Blake. 1993. The molecular epidemiology of cholera in Latin America. J. Infect. Dis. 167: 621– 626.

38. Wallace, C. K.,, P. N. Anderson,, T. C. Brown,, S. R. Khanra,, G. W. Lewis,, N. F. Pierce,, S. N. Sanyal,, G. V. Segre,, and R. H. Waldman. 1968. Optimal antibiotic therapy in cholera. Bull W.H.O. 39: 239– 245.

39. Yamomoto, K.,, Y. Ichinose,, N. Nakasone,, M. Tanabe,, M. Nagahama,, J. Sakurai,, and M. Iwanaga. 1986. Identity of hemolysins produced by Vibrio cholerae non-Ol and Vibrio cholerae Ol, biotype El Tor. Infect. Immun. 51: 927– 937.

Tables

Nontoxigenic Vibrio cholerae O1 Infections in the United States

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Table 1

Laboratory characteristics of 14 NT V. cholerae O1 isolates, United States, 1977 to 1991

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Table 1

Laboratory characteristics of 14 NT V. cholerae O1 isolates, United States, 1977 to 1991

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Table 2

Genotypic characteristics of NT V. cholerae O1 strains

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Table 2

Genotypic characteristics of NT V. cholerae O1 strains

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Table 3

Features of 14 patients from whom NT V. cholerae O1 was isolated, United States, 1977 to 1991

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Table 3

Features of 14 patients from whom NT V. cholerae O1 was isolated, United States, 1977 to 1991

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Table 4

Symptoms of 10 patients with NT V. cholerae O1 isolated from stool

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10.1128/9781555818364/tab5-4.gif

Table 4

Symptoms of 10 patients with NT V. cholerae O1 isolated from stool

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