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Category: Bacterial Pathogenesis; Microbial Genetics and Molecular Biology
Translation and Its Regulation, Page 1 of 2
< Previous page | Next page > /docserver/preview/fulltext/10.1128/9781555818388/9781555810535_Chap48-1.gif /docserver/preview/fulltext/10.1128/9781555818388/9781555810535_Chap48-2.gifAbstract:
This chapter reviews the current status of translation in Bacillus subtilis since publication of a paper on translational specificity by Hager and Rabinowitz. It describes the important features of a B. subtilis ribosome binding site (RBS) as distinct from an Escherichia coli RBS and suggests a subtly different mechanism for initiation, taking into account the known requirements for efficient initiation. From these features, potential sites for translational regulation governing the overall yield of protein product is proposed, and a discussion of known translational regulatory mechanisms in B. subtilis follows. Finally, the chapter compares and contrasts the translational characteristics of other gram-positive organisms, including those from the high-G+C-content actinomycete group. Although this discussion has focused on control at the level of initiation of translation, other means determine the translatability of a message in B. subtilis. The production of an antisense RNA transcript controls the synthesis of RepH and, in turn, the replica of pC194.
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Phylogenetic relationships among selected eubacteria and translational specificity. Groupings are based on binary association coefficients (SABs) ( 30 ) of 16S rRNA sequences.
Phylogenetic relationships among selected eubacteria and translational specificity. Groupings are based on binary association coefficients (SABs) ( 30 ) of 16S rRNA sequences.
Schematics of alternative secondary structures involved in translational attenuation of the ermC gene. See text for discussion.
Schematics of alternative secondary structures involved in translational attenuation of the ermC gene. See text for discussion.