Chapter 7 : Leishmania: a Parasite on the Move

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During the past decade, there has been an increase in numbers of new cases, spread of the disease into new regions, and even appearance of new clinical syndromes. This resurgence of leishmaniasis reflects the remarkable adaptability of the parasite to changing conditions, such as those resulting from economic development, human modification of the environment, and population movements. In visceral leishmaniasis, or kala-azar, there is infection of reticuloendothelial cells throughout the body and particularly in the liver, spleen, bone marrow, and lymphoid tissue. In cutaneous leishmaniasis, parasite replication is confined primarily to the skin. Treatment is required for persons with clinically apparent visceral leishmaniasis, mucocutaneous leishmaniasis, and cases of cutaneous leishmaniasis in which spontaneous healing is slow, lesions involve the face, or infection is due to species that can cause mucocutaneous leishmaniasis or diffuse cutaneous leishmaniasis. The gold standard treatment is pentavalent antimony given intravenously or intramuscularly at a dose of 20 mg/kg/day for a minimum of 20 days. Visceral leishmaniasis in HIV-infected persons is associated with higher levels of parasitemia than is seen in non-HIV-infected persons, and sand flies readily acquire parasites from coinfected persons. Measures to control the spread of visceral leishmaniasis in Teresina have focused on identifying and killing infected dogs, and application of insecticide in the neighborhoods surrounding new cases of frank kala-azar. High among the priorities for research on leishmaniasis is the development of new methods for predicting the occurrence of outbreaks and establishment of new foci of transmission.

Citation: Maguire J. 1999. Leishmania: a Parasite on the Move, p 99-110. In Scheld W, Craig W, Hughes J (ed), Emerging Infections 3. ASM Press, Washington, DC. doi: 10.1128/9781555818418.ch7
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1., Alvar, J.,, C. Canavate, B. Gutierrez-Solar,, M. Jimenez,, F. Laguna,, R- Lopez-Velez,, R. Mo1ina,, and J. Moreno. 1997. Leishmania and human Immunodeficiency virus coinfection: the first 10 years, Clin. Microbiol. Rev. 10: 298 319.
2. Alvar, J.,, and M. Jimenez. 1994. Could infected drug-users be potential Leishmania infantum reservoirs? AIDS 8: 854. (Letter.)
3. Arias, J. R.,, and R. D. Naiff. 1981. The principal reservoir host of cutaneous leishmaniasis in the urban area. of Manaus, Central Amazon of Brazil. Mem. Inst. Oswaldo Cruz 76: 279 286.
4. Ashford, R. W.,, and M. C. Thomson, 1991. Visceral leishmaniasis in Sudan. A delayed development disaster? Ann. Trop. Med. Parasitol. 85: 571 572.
5. Badaró, R.,, T. C. Jones,, C. R. Lorenço,. B, J. Cerf,, D. Sampaio,, E. M, Carvalho,, H. Rocha,, R. Teixeira,, and W. D. Johnson, Jr. 1986. A prospective study of visceral leishmaniasis in an endemic area of Brazil. J. Infect. Dis. 154: 639 649.
6. Barral, A,,. R. Badaro,, M, BarraI-Netto,, G. Grimaldi, Jr.,, H. Momem,, and E. M. Carvalho, 1986. Isolation of Leishmania mexicana amazonensis from the bone marrow in a case of American visceral leishmaniasis. Am J. Trop. Med. Hyg. 35: 732 734.
7. Beronguer, J.,, F. Gomez-Campdera,, B. Padilla,, M. Rodriguez-Ferrero,, F. Anaya,, S, Moreno,, and F. Valderrabano. 1998. Viscera) leishmaniasis (Kala-Azar) in transplant recipients: case report and review. Transplantation 65: 1401 1404.
8. Berrnan J. D. 1997. Human leishmaniasis: clinicai, diagnostic, and chemotherapeutic developments in the last 10 years. Clin. Infect. Dis. 24: 684 703.
9. Braodão-PiIho, S.,, and J. Shaw. 1994. Leishmaniasis in Brazil. Parasitol. Today 10: 329 330.
10. Bryceson, A. D., 1996. Leishmaniasis, p. 1213 1245. In G. C. Cook (ed.), Manson's Tropical Diseases, 20th ed. The W. B. Saunders Co., Philadelphia. Pa.
11. Costa, C. H.,, H. F. Pereira,, and M V, Araujo. 1990. Epidemia de leishmaniose visceral no estado do Piauí. Brasil, 1980-1986. Rev. Saúde Pública 24: 361 372.
12. de Beer, P.,, A. el Harith,, M, van Grootheest,, and A. Winkler. 1990. Outbreak of kala-azar in the Sudan. Lancet 335: 224. (Letter)
13. Desjeux, P. 1992. Human leishmaniases: epidemiology and public health aspects. World Health Stat. Q. 45: 267 275.
14. Dye, C. 1992. Leishmaniasis epidemiology: the theory catches up. Parasitology 104( Suppl.l): S7 S18.
15. Dye, C. 1996. The logic of visceral leishmaniasis control. Am. J. Trap. Med. Hyg. 55: 125 130.
16. Evans, T. G.,, M. J. Teixeira,, I. T. McAuliffe,, I. Vasconcelos,, A. Vasconcelos,, A, Sousa,. J. Lima,, and R. A. Pearson. 1992, Epidemiology of visceral leishmaniasis in Northeast Brazil. J. Infect. Dis. 166: 1124 1132,
17. Fundação Nacional de Saúde 1998, Statistics on leishmaniasis, Fundaçao Nacional de Saúde, Brasilia. Brazil.
18. Giladi. M.,, C. Block,, Y. L, Danon,, E. Schinder,, and C. L. Greenblatt. 1988, Local environmental risk factors in the acquisition of cutaneous leishmaniasis.lsr. J. Med. Sci. 24: 185 187.
19. Gratz, N. G. 1999. Emerging and resurging vector-borne diseases, Annu. Rev. Entomol. 44: 51 75.
20., Herwaldt, B. L.,, S. L. Stokes,, and D. D. Juranek. 1993. American cutaneous leishmaniasis in U,S, travelers. Ann. Intern. Med, 118: 779 784.
21. Jeronimo, S. M.,, R. M. Oliveira,, S. Mackay,, R. M. Costa,, J. Sweet,, E. T. Nascimento,, K. G, Luz,, M. Z. Fernandes,, J. Jernigan,, and R. D. Pearson. 1994 , An urban outbreak of visceral leishmaniasis in Natal, Brazil. Trans. R. Soc. Trop. Med. Hyg. 88: 386 388.
22. Killick-Kendrick, R. 1990. The life-cycle of Leishmania in the sandfly with special reference to the form infective to the vertebrate host Ann. Parasitol. Hum. Comp. 65( Suppl. 1): 37 42.
23. Lajnson, R. 1988. Ecological interactions in the transmission of the leishmaniases. Philos. Trans. R. Soc. Lond, 321: 389 404.
24. Lainson, R.,, and J. J. Shaw, 1978. Epidemiology and ecology of leishmaniasis in Latin-America. Nature 273: 595 600.
25., Lainson, R.,, L. Ryan,, and J. J. Shaw. 1987. Infective stages of Leishmania in the ,sandfly vector and some observations on the mechanism of transmission. Mem. Inst. Oswaldo Cruz 82: 421 424.
26.Lainsont R. 1985. Our present knowledge of the ecology and control of leishmaniasis in the Amazon region of Brazil Rev. Soc. Bras. Med. Trap. 18: 4756.
27., Lara, M. L.,, Z. Layrisse,, J. V. Scorza,, E. Garcia,, Z. Stoikow,, J. Granados,, and W. Bias. 1991. Immunogenetics of human American cutaneous leishmaniasis. Study of HLA haplotypes in 24 families from Venezuela, Hum, Immunol 30: 129 135.
28., Magill, A, J. 1995 , Epidemiology of the leishmaniases, Dermatol. Clin. 13: 505 523.
29., Maguire, J, B.,, C. H. Costa,, D. Lamounier,, L. Beck,, B. Lobitz,, S. Dister,, and B. Wood. 1999. Application for remote sensing and geographical information systems (GIS) technology to study transmission of Leishmania chagasl in Teresina, Piaui, Brazil. http://geo.arc.nasa.gov/sge/heaitb/ projects/leishb/leishb.
30., Maguire, J. H.,, N. M. Gantz,, S. Moschella,, and S. C. Pan, 1983 , Leishmanial infections: a consideration in travellers returning from abroad, Am. J. Med. Sci. 285: 32 40.
31. McGregor, A. 1998, WHO warns of epidemic leishmania, Lancet 351: 575.
32., McHugh, C. P.,, P. C. Melby,, and S. G. Lafon. 1996. Leishmaniasis in Texas: epidemiology and clinical aspects of human cases, Am. J. Trop. Med. Hyg. 55: 547 555.
33. Molyneux, D. H. 1997 , Patterns of change in vector-borne diseases, Ann. Trop. Med. Parasitol. 91: 827 839.
34. Molyneux, D. H. 1998 , Vector-borne- parasitic disease—an overview of recent changes. Int. J. Parasitol, 28: 927 934.
35.. National Aeronautics and Space Administration. 1998, NASA: CHAART Satellite and Sensor Evaluation for Public Health, http://geo.arc.nasa,gov/sge/healthl sensor I sensor.htm.
36., Pearson, R. D.,, and A. Q. Sousa. 1996 , Clinical spectrum of leishmaniasis, Clin. Infect Dis, 22: 1 13.
37., Ponce, C.,, E. Ponce,, A. Morrison,, A. Cruz,, R. Kreutzer,, D. McMahon-Pratt,, and F, Neva. 1991. Leishmania donovani chagasi: new clinical variant of cutaneous leishmaniasis in Honduras. Lancet 337: 67 70.
38., Punda-Polic. V.,, S. Sardelic,, and N. Bradaric. 1998. Visceral leishmaniasis in southern Croatia, Lancet 351: 188, (Letter,)
39. Seaman, J.,, A. J. Mercer,, and E. Sondorp. 1996, The epidemic of visceral leishmaniasis in western Upper Nile. southern Sudan: course and impact from 1984 to 1994, Int. J. Epidemiol. 25: 862 871.
40., Seaman, J.,, R. W. Ashford,, J. Schorscher,, and J. Dereure. 1992 Visceral leishmaniasis in southern Sudan: status of healthy villagers in epidemic conditions. Ann. Trap. Med. Parasitol. 86: 481 486.
41. Sherlock, I. A. 1996 , Ecological interactions of visceral leishmaniasis in the State of Bahia, Brazil. Mem. Inst. Oswaldo Cruz 91: 671 683.
42., Sonsa, A. Q.,, M. E. Parise,, M. M. Pompeu,, J. M. Coelho Filho,, I. A. Vasconcelos,, J. W. Lima,, E. G. Oliveira,, A. W. Vasconcelos,, J. R. David,, and J. H. Maguire. 1995. Bubonic leishmaniasis: a common manifestation of Leishmania (Viannia) braziliensis infection in Ceara, Brazil Am. J. Trap. Med. Hyg. 53: 380 385.
43. Sundar. S.,, S. K. Agrawal,, P. R. Sinha,, G. S. Horwith,, and H. W. Murray. 1997. Short-course, low-dose amphotericin B lipid complex therapy for visceral leishmaniasis unresponsive to antimony, Ann. Intern. Med. 127: 133 137.
44., Tesh, R. B. 1995. Control of leishmaniasis: is it time to change strategies? Am. J. Trap. Med. Hyg. 52: 287 292.
45. Tesh, R. B.,, and G. Papaevangelou. 1977. Effect of insecticide spraying for malaria control on the incidence of sandBy fever in Athens, Greece. Am. J. Trop. Med. Hyg. 26: 163 166.
46. Walton, B. C. 1989. Leishmaniasis. A worldwide problem, Int. J Dermatol. 28: 305 307.
47. Wijeyaratne, P. M.,, L. K. Arsenault,, and C. J. Murphy. 1994. Endemic disease and development: the leishmaniases. Acta Trop. 56: 349 364.
48. World Health Organization Division of Control of Tropical Diseases. 1998, Disease Sheet: Leishmaniasis. http://www.who.ch.programmes/ctd/diseaseslleis/.

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