Chapter 17 : Regulation of the Expression of Type III Secretion Systems: an Example from

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This chapter presents a general overview of type III secretion system (T3SS) regulation in the main pathogenic bacteria, and focuses on the different aspects of the regulation of T3SS gene expression in . Pathogenic bacteria occupy very different infection foci; for instance, the animal pathogens spp. and spp. live intracellularly after successful invasion, whereas spp., , and enteropathogenic (EPEC) predominantly remain extracellular. Therefore, different stimuli could be used to up or downregulate the expression of T3SS genes: temperature, divalent cations, host cell contact, serum, or other factors. Although the mechanism by which metabolic pathways influence virulence gene expression in bacteria is unclear, the example of detailed could facilitate progress in that field. It has been shown that T3SS expression is dependent on cell density and that CEBA operon expression decreases rapidly in the second part of stationary phase, and also that indole-3-acetic acid (IAA), naphthalenacetic, and 3-hydroxykynurenine inhibit CEBA operon expression at millimolar concentrations. In 2005, Wu and coworkers proposed that the opportunistic pathogen could adapt to the host by sensing alterations in the host immune function and respond by enhancing the virulence phenotype. Despite the large number of genes that influence the regulation of the expression of T3SS genes in , only a minority have been shown to have a precise role. Both fundamental and applied research can make the inhibition of T3SS expression as one of the first new antibacterial therapeutics.

Citation: Le Gouellec A, Polack B, Toussaint B, Dakang. 2013. Regulation of the Expression of Type III Secretion Systems: an Example from , p 317-334. In Vasil M, Darwin A (ed), Regulation of Bacterial Virulence. ASM Press, Washington, DC. doi: 10.1128/9781555818524.ch17
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Multiple aspects of T3SS regulation in . doi:10.1128/9781555818524.ch17f1

Citation: Le Gouellec A, Polack B, Toussaint B, Dakang. 2013. Regulation of the Expression of Type III Secretion Systems: an Example from , p 317-334. In Vasil M, Darwin A (ed), Regulation of Bacterial Virulence. ASM Press, Washington, DC. doi: 10.1128/9781555818524.ch17
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Schema of type III secretion system regulation in . doi:10.1128/9781555818524.ch17f2

Citation: Le Gouellec A, Polack B, Toussaint B, Dakang. 2013. Regulation of the Expression of Type III Secretion Systems: an Example from , p 317-334. In Vasil M, Darwin A (ed), Regulation of Bacterial Virulence. ASM Press, Washington, DC. doi: 10.1128/9781555818524.ch17
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Table 1

Summary of the main regulatory characteristics of the T3SSs of several animal pathogens

Citation: Le Gouellec A, Polack B, Toussaint B, Dakang. 2013. Regulation of the Expression of Type III Secretion Systems: an Example from , p 317-334. In Vasil M, Darwin A (ed), Regulation of Bacterial Virulence. ASM Press, Washington, DC. doi: 10.1128/9781555818524.ch17

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