Chapter 103 : Celiac Disease and Inflammatory Bowel Disease

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Celiac disease (CeD) and inflammatory bowel disease (IBD) are chronic inflammatory diseases affecting the gastrointestinal tract. They share certain characteristics, including autoimmune features, the presence of both gastrointestinal and systemic clinical symptoms, and pathogenic contributions by genetic and environmental factors. However, there are several stark differences that must be appreciated. The immunogenic mechanisms of the two diseases are unique, with differing contributions by the innate and adaptive immune responses. Histologically, CeD is distinct from IBD, which is useful diagnostically as well as for gaining insight into disease mechanisms. Lastly, the role of diagnostic laboratory testing, both serologic and genetic, differs greatly between CeD and IBD. The purpose of this chapter is to provide a summary of what is currently known about the pathogenesis, epidemiology, clinical presentation, and diagnostic testing for CeD and IBD.

Citation: Snyder M. 2016. Celiac Disease and Inflammatory Bowel Disease, p 983-989. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch103
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Image of FIGURE 1

EMA by indirect immunofluorescence. The presence of an EMA is identified based on the appearance of latticework staining of the endomysium surrounding the smooth muscle fiber. This photo is a 10× magnification of an indirect immunofluorescence method using monkey esophagus. (Photo courtesy of the Immunodermatology Laboratory, Mayo Clinic, Rochester, MN.)

Citation: Snyder M. 2016. Celiac Disease and Inflammatory Bowel Disease, p 983-989. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch103
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Generic image for table

Summary of serologic tests available for evaluation of suspected CeD and IBD

Citation: Snyder M. 2016. Celiac Disease and Inflammatory Bowel Disease, p 983-989. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch103

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