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Chapter 60 : Epstein-Barr Virus and Cytomegalovirus

Authors: Henry H. Balfour Jr.1, Kristin A. Hogquist2, Priya S. Verghese3
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Affiliations: 1: University of Minnesota Medical School, Laboratory Medicine & Pathology, and Pediatrics, MMC 609, 420 Delaware St. SE, Minneapolis, MN 55455; 2: Center for Immunology, University of Minnesota, 2-186 MBB, 2101 6th St. SE, Minneapolis, MN 55455; 3: Pediatric Kidney Transplantation, University of Minnesota, Children's Hospital, 2450 Riverside Ave., MB 687, Minneapolis, MN 55454
Content Type: Reference
Publication Year: 2016

Category: Immunology

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Epstein-Barr Virus and Cytomegalovirus, Page 1 of 2

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Abstract:

Epstein-Barr virus (EBV; also known as human herpesvirus 4 [HHV-4]) and cytomegalovirus (CMV; also known as HHV-5) logically belong in the same chapter. Both of these human herpesviruses are major pathogens for the immunocompromised host, and both are capable of causing disease during primary infection, reactivation, or superinfection. They, along with BK polyomavirus, are the feared viral triumvirate that complicates hematopoietic cell transplantation (HCT) or solid organ transplantation. This chapter emphasizes recognition of EBV and CMV diseases and focuses on the clinical relevance of laboratory findings.

Citation: Balfour H, Hogquist K, Verghese P. 2016. Epstein-Barr Virus and Cytomegalovirus, p 563-577. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch60
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Epstein-Barr Virus and Cytomegalovirus
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Citation: Balfour H, Hogquist K, Verghese P. 2016. Epstein-Barr Virus and Cytomegalovirus, p 563-577. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch60
/content/10.1128/9781555818722.ch60.ch60fig1
FIGURE 1

Correlations between time of primary infection, disease expression, immune responses, and viral loads.

10.1128/9781555818722/8722ch60fig1_thmb.gif
10.1128/9781555818722/8722ch60fig1.gif
Image of FIGURE 1
FIGURE 1

Correlations between time of primary infection, disease expression, immune responses, and viral loads.

Citation: Balfour H, Hogquist K, Verghese P. 2016. Epstein-Barr Virus and Cytomegalovirus, p 563-577. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch60
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Tables

Epstein-Barr Virus and Cytomegalovirus
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Citation: Balfour H, Hogquist K, Verghese P. 2016. Epstein-Barr Virus and Cytomegalovirus, p 563-577. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch60
/content/10.1128/9781555818722.ch60.ch60tab1
TABLE 1

Recommended laboratory tests for diagnosis and management of EBV infections

Generic image for table
TABLE 1

Recommended laboratory tests for diagnosis and management of EBV infections

Citation: Balfour H, Hogquist K, Verghese P. 2016. Epstein-Barr Virus and Cytomegalovirus, p 563-577. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch60
/content/10.1128/9781555818722.ch60.ch60tab2
TABLE 2

EBV infection category according to patterns of EBV-specific antibody tests

Generic image for table
TABLE 2

EBV infection category according to patterns of EBV-specific antibody tests

Citation: Balfour H, Hogquist K, Verghese P. 2016. Epstein-Barr Virus and Cytomegalovirus, p 563-577. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch60
/content/10.1128/9781555818722.ch60.ch60tab3
TABLE 3

Laboratory tests for diagnosis and management of CMV infections

Generic image for table
TABLE 3

Laboratory tests for diagnosis and management of CMV infections

Citation: Balfour H, Hogquist K, Verghese P. 2016. Epstein-Barr Virus and Cytomegalovirus, p 563-577. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch60

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