Chapter 60 : Epstein-Barr Virus and Cytomegalovirus

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Epstein-Barr virus (EBV; also known as human herpesvirus 4 [HHV-4]) and cytomegalovirus (CMV; also known as HHV-5) logically belong in the same chapter. Both of these human herpesviruses are major pathogens for the immunocompromised host, and both are capable of causing disease during primary infection, reactivation, or superinfection. They, along with BK polyomavirus, are the feared viral triumvirate that complicates hematopoietic cell transplantation (HCT) or solid organ transplantation. This chapter emphasizes recognition of EBV and CMV diseases and focuses on the clinical relevance of laboratory findings.

Citation: Balfour H, Hogquist K, Verghese P. 2016. Epstein-Barr Virus and Cytomegalovirus, p 563-577. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch60
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Correlations between time of primary infection, disease expression, immune responses, and viral loads.

Citation: Balfour H, Hogquist K, Verghese P. 2016. Epstein-Barr Virus and Cytomegalovirus, p 563-577. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch60
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Generic image for table

Recommended laboratory tests for diagnosis and management of EBV infections

Citation: Balfour H, Hogquist K, Verghese P. 2016. Epstein-Barr Virus and Cytomegalovirus, p 563-577. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch60
Generic image for table

EBV infection category according to patterns of EBV-specific antibody tests

Citation: Balfour H, Hogquist K, Verghese P. 2016. Epstein-Barr Virus and Cytomegalovirus, p 563-577. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch60
Generic image for table

Laboratory tests for diagnosis and management of CMV infections

Citation: Balfour H, Hogquist K, Verghese P. 2016. Epstein-Barr Virus and Cytomegalovirus, p 563-577. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch60

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