Chapter 70 : Human T-Cell Lymphotropic Virus Types 1 and 2

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Human T-cell lymphotropic virus type 1 (HTLV-1) was the first pathogenic human retrovirus to be discovered. It was isolated in 1979 from the peripheral blood lymphocytes of a patient with adult T-cell leukemia/lymphoma (ATLL) (1). Following years of research to find a retroviral agent involved in ATLL, Yoshida and Yamamato isolated a retrovirus from an ATLL patient in 1986 that they named adult T-cell leukemia virus. Soon, the similarities between HTLV-1 and adult T-cell leukemia virus were confirmed, and the name HTLV-1 was chosen. Shortly thereafter, the closely related virus HTLV-2 was isolated from the splenic cells of an individual with hairy cell T-cell leukemia (2).

Citation: Caruso B, Massoud R, Jacobson S. 2016. Human T-Cell Lymphotropic Virus Types 1 and 2, p 674-681. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch70
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Image of FIGURE 1

Representative examples of HTLV-1-positive and HTLV-2-positive WB patterns. WB patterns can also demonstrate indeterminate reactivity, and two examples of this are shown here (IND-1 and -2). This can complicate the interpretation of results.

Citation: Caruso B, Massoud R, Jacobson S. 2016. Human T-Cell Lymphotropic Virus Types 1 and 2, p 674-681. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch70
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Viral target regions and reference materials for quantification of HTLV-1 and -2 by qPCR

Citation: Caruso B, Massoud R, Jacobson S. 2016. Human T-Cell Lymphotropic Virus Types 1 and 2, p 674-681. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch70

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