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Chapter 92 : Antibody and Biomarker Testing in Rheumatoid Arthritis

Authors: Ann Duskin Chauffe1, Michael Raymond Bubb2
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Affiliations: 1: Division of Rheumatology, University of Florida, 1600 S.W. Archer Rd D2-39, P.O. Box 100221, Gainesville, FL 32610; 2: Division of Rheumatology, University of Florida, 1600 S.W. Archer Rd D2-39, P.O. Box 100221, Gainesville, FL 32610
Content Type: Reference
Publication Year: 2016

Category: Immunology

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Abstract:

Rheumatoid arthritis (RA) is a chronic systemic disease characterized by autoimmune-mediated joint destruction. RA affects 1% of the global population with a predilection for females. The pathogenesis of RA has not been fully elucidated; however, it is thought to be due to an environmental trigger stimulating an immune response in a genetically susceptible host. The resultant inflammatory cascade mediates synovial proliferation and ultimately joint destruction. Disease expression is not limited to the joints. Extra-articular manifestations occur in the lungs, eyes, skin, and the cardiovascular system culminating in significant morbidity and premature mortality (1). Moreover, numerous studies show substantial irreversible joint damage occurs within the first 2 years of disease onset. Thus, early diagnosis and aggressive treatment is paramount in preventing morbidity and mortality (2).

Citation: Chauffe A, Bubb M. 2016. Antibody and Biomarker Testing in Rheumatoid Arthritis, p 897-904. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch92
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References

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Tables

Antibody and Biomarker Testing in Rheumatoid Arthritis
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Citation: Chauffe A, Bubb M. 2016. Antibody and Biomarker Testing in Rheumatoid Arthritis, p 897-904. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch92
/content/10.1128/9781555818722.ch92.ch92tab1
TABLE 1

Summary of well-characterized autoantigens in rheumatoid arthritis

Generic image for table
TABLE 1

Summary of well-characterized autoantigens in rheumatoid arthritis

Citation: Chauffe A, Bubb M. 2016. Antibody and Biomarker Testing in Rheumatoid Arthritis, p 897-904. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch92
/content/10.1128/9781555818722.ch92.ch92tab2
TABLE 2

Comparison of antibody assays

Generic image for table
TABLE 2

Comparison of antibody assays

Citation: Chauffe A, Bubb M. 2016. Antibody and Biomarker Testing in Rheumatoid Arthritis, p 897-904. In Detrick B, Schmitz J, Hamilton R (ed), Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818722.ch92

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