Chapter 11 : Animal Reservoirs of Shiga Toxin-Producing

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strains that carry Shiga toxin genes are commonly isolated from the gastrointestinal tract of a wide variety of animal species ( Table 1 ). Intestinal carriage of most Shiga toxin-producing (STEC) strains by domestic and wild animals has little clinical relevance to either the animal hosts or humans. Most animals lack receptors for Shiga toxin, and in humans, the presence of additional virulence factors, in addition to the gene, is associated with disease outcomes ( ). However, animals may harbor STEC strains that are pathogenic to humans. This article focuses on the role of animals as reservoirs for infection or as spillover hosts. Within the animal, these bacteria may be resident or transient in the gastrointestinal tract. Determining whether STEC is resident in flora or transient is not possible during cross-sectional observational epidemiological studies when only one sample is collected from an animal and there is no serial testing. Even under experimental conditions it is difficult to determine if repeated isolation from the feces over time is a result of replication of the organism in the animal or repeated exposure.

Citation: Persad A, Lejeune J. 2015. Animal Reservoirs of Shiga Toxin-Producing , p 231-244. In Sperandio V, Hovde C (ed), Enterohemorrhagic and Other Shiga Toxin-Producing . ASM Press, Washington, DC. doi: 10.1128/microbiolspec.EHEC-0027-2014
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1. Gyles CL . 2007. Shiga toxin-producing Escherichia coli: an overview. J Anim Sci 85 : E45 E62.[PubMed] [CrossRef]
2. Etcheverria AI,, Padola NL . 2013. Shiga toxin-producing Escherichia coli: factors involved in virulence and cattle colonization. Virulence 4 : 366 372.[PubMed] [CrossRef]
3. Friedrich AW,, Bielaszewska M,, Zhang WL,, Pulz M,, Kuczius T,, Ammon A,, Karch H . 2002. Escherichia coli harboring Shiga toxin 2 gene variants: frequency and association with clinical symptoms. J Infect Dis 185 : 74 84.[PubMed] [CrossRef]
4. Bennani M,, Badri S,, Baibai T,, Oubrim N,, Hassar M,, Cohen N,, Amarouch H . 2011. First detection of Shiga toxin-producing Escherichia coli in shellfish and coastal environments of Morocco. Appl Biochem Biotechnol 165 : 290 299.[PubMed] [CrossRef]
5. Manna SK,, Das R,, Manna C . 2008. Microbiological quality of finfish and shellfish with special reference to shiga toxin-producing Escherichia coli O157. J Food Sci 73 : M283 M286.[PubMed] [CrossRef]
6. Gourmelon M,, Montet MP,, Lozach S,, Le Mennec C,, Pommepuy M,, Beutin L,, Vernozy-Rozand C . 2006. First isolation of Shiga toxin 1d producing Escherichia coli variant strains in shellfish from coastal areas in France. J Appl Microbiol 100 : 85 97.[PubMed] [CrossRef]
7. Besser TE,, Richards BL,, Rice DH,, Hancock DD . 2001. Escherichia coli O157:H7 infection of calves: infectious dose and direct contact transmission. Epidemiol Infect 127 : 555 560.[PubMed] [CrossRef]
8. Pruimboom-Brees IM,, Morgan TW,, Ackermann MR,, Nystrom ED,, Samuel JE,, Cornick NA,, Moon HW . 2000. Cattle lack vascular receptors for Escherichia coli O157:H7 Shiga toxins. Proc Natl Acad Sci USA 97 : 10325 10329.[PubMed] [CrossRef]
9. Nguyen Y,, Sperandio V . 2012. Enterohemorrhagic E. coli (EHEC) pathogenesis. Front Cell Infect Microbiol 2 : 90. [PubMed] [CrossRef]
10. Naylor SW,, Low JC,, Besser TE,, Mahajan A,, Gunn GJ,, Pearce MC,, McKendrick IJ,, Smith DG,, Gally DL . 2003. Lymphoid follicle-dense mucosa at the terminal rectum is the principal site of colonization of enterohemorrhagic Escherichia coli O157:H7 in the bovine host. Infect Immun 71 : 1505 1512.[PubMed] [CrossRef]
11. Vanaja SK,, Springman AC,, Besser TE,, Whittam TS,, Manning SD . 2010. Differential expression of virulence and stress fitness genes between Escherichia coli O157:H7 strains with clinical or bovine-biased genotypes. Appl Environ Microbiol 76 : 60 68.[PubMed] [CrossRef]
12. Fairbrother JM,, Nadeau E . 2006. Escherichia coli: on-farm contamination of animals. Rev Sci Tech 25 : 555 569.[PubMed]
13. Gagliardi JV,, Karns JS . 2000. Leaching of Escherichia coli O157:H7 in diverse soils under various agricultural management practices. Appl Environ Microbiol 66 : 877 883.[PubMed] [CrossRef]
14. LeJeune JT,, Besser TE,, Merrill NL,, Rice DH,, Hancock DD . 2001. Livestock drinking water microbiology and the factors influencing the quality of drinking water offered to cattle. J Dairy Sci 84 : 1856 1862.[PubMed] [CrossRef]
15. LeJeune JT,, Besser TE,, Hancock DD . 2001. Cattle water troughs as reservoirs of Escherichia coli O157. Appl Environ Microbiol 67 : 3053 3057.[PubMed] [CrossRef]
16. Garber L,, Wells S,, Schroeder-Tucker L,, Ferris K . 1999. Factors associated with fecal shedding of verotoxin-producing Escherichia coli O157 on dairy farms. J Food Prot 62 : 307 312.[PubMed]
17. Lejeune JT,, Kauffman MD . 2005. Effect of sand and sawdust bedding materials on the fecal prevalence of Escherichia coli O157:H7 in dairy cows. Appl Environ Microbiol 71 : 326 330.[PubMed] [CrossRef]
18. Cernicchiaro N,, Pearl DL,, Ghimire S,, Gyles CL,, Johnson RP,, LeJeune JT,, Ziebell K,, McEwen SA . 2009. Risk factors associated with Escherichia coli O157:H7 in Ontario beef cow-calf operations. Prev Vet Med 92 : 106 115.[PubMed] [CrossRef]
19. Hancock D,, Besser T,, Lejeune J,, Davis M,, Rice D . 2001. The control of VTEC in the animal reservoir. Int J Food Microbiol 66 : 71 78.[PubMed] [CrossRef]
20. Lira WM,, Macedo C,, Marin JM . 2004. The incidence of Shiga toxin-producing Escherichia coli in cattle with mastitis in Brazil. J Appl Microbiol 97 : 861 866.[PubMed] [CrossRef]
21. Cerqueira AM,, Guth BE,, Joaquim RM,, Andrade JR . 1999. High occurrence of Shiga toxin-producing Escherichia coli (STEC) in healthy cattle in Rio de Janeiro State, Brazil. Vet Microbiol 70 : 111 121.[PubMed] [CrossRef]
22. Farrokh C,, Jordan K,, Auvray F,, Glass K,, Oppegaard H,, Raynaud S,, Thevenot D,, Condron R,, De Reu K,, Govaris A,, Heggum K,, Heyndrickx M,, Hummerjohann J,, Lindsay D,, Miszczycha S,, Moussiegt S,, Verstraete K,, Cerf O . 2013. Review of Shiga-toxin-producing Escherichia coli (STEC) and their significance in dairy production. Int J Food Microbiol 162 : 190 212.[PubMed] [CrossRef]
23. Hancock DD,, Besser TE,, Kinsel ML,, Tarr PI,, Rice DH,, Paros MG . 1994. The prevalence of Escherichia coli O157.H7 in dairy and beef cattle in Washington state. Epidemiol Infect 113 : 199 207.[PubMed] [CrossRef]
24. Hussein HS,, Bollinger LM . 2005. Prevalence of Shiga toxin-producing Escherichia coli in beef cattle. J Food Prot 68 : 2224 2241.[PubMed]
25. Hussein HS,, Sakuma T . 2005. Prevalence of shiga toxin-producing Escherichia coli in dairy cattle and their products. J Dairy Sci 88 : 450 465.[PubMed] [CrossRef]
26. Fegan N,, Vanderlinde P,, Higgs G,, Desmarchelier P . 2004. The prevalence and concentration of Escherichia coli O157 in faeces of cattle from different production systems at slaughter. J Appl Microbiol 97 : 362 370.[PubMed] [CrossRef]
27. Widiasih DA,, Ido N,, Omoe K,, Sugii S,, Shinagawa K . 2004. Duration and magnitude of faecal shedding of Shiga toxin-producing Escherichia coli from naturally infected cattle. Epidemiol Infect 132 : 67 75.[PubMed] [CrossRef]
28. Lim JY,, Li J,, Sheng H,, Besser TE,, Potter K,, Hovde CJ . 2007. Escherichia coli O157:H7 colonization at the rectoanal junction of long-duration culture-positive cattle. Appl Environ Microbiol 73 : 1380 1382.[PubMed] [CrossRef]
29. Chase-Topping M,, Gally D,, Low C,, Matthews L,, Woolhouse M . 2008. Super-shedding and the link between human infection and livestock carriage of Escherichia coli O157. Nat Rev Microbiol 6 : 904 912.[PubMed] [CrossRef]
30. Omisakin F,, MacRae M,, Ogden ID,, Strachan NJ . 2003. Concentration and prevalence of Escherichia coli O157 in cattle feces at slaughter. Appl Environ Microbiol 69 : 2444 2447.[PubMed] [CrossRef]
31. Williams ML,, Pearl DL,, Bishop KE,, Lejeune JT . 2013. Use of multiple-locus variable-number tandem repeat analysis to evaluate Escherichia coli O157 subtype distribution and transmission dynamics following natural exposure on a closed beef feedlot facility. Foodborne Pathog Dis 10 : 827 834.[PubMed] [CrossRef]
32. Matthews L,, Low JC,, Gally DL,, Pearce MC,, Mellor DJ,, Heesterbeek JA,, Chase-Topping M,, Naylor SW,, Shaw DJ,, Reid SW,, Gunn GJ,, Woolhouse ME . 2006. Heterogeneous shedding of Escherichia coli O157 in cattle and its implications for control. Proc Natl Acad Sci USA 103 : 547 552.[PubMed] [CrossRef]
33. Nielsen EM,, Tegtmeier C,, Andersen HJ,, Gronbaek C,, Andersen JS . 2002. Influence of age, sex and herd characteristics on the occurrence of verocytotoxin-producing Escherichia coli O157 in Danish dairy farms. Vet Microbiol 88 : 245 257.[PubMed] [CrossRef]
34. La Ragione RM,, Best A,, Woodward MJ,, Wales AD . 2009. Escherichia coli O157:H7 colonization in small domestic ruminants. FEMS Microbiol Rev 33 : 394 410.[PubMed] [CrossRef]
35. Brandal LT,, Sekse C,, Lindstedt BA,, Sunde M,, Lobersli I,, Urdahl AM,, Kapperud G . 2012. Norwegian sheep are an important reservoir for human-pathogenic Escherichia coli O26:H11. Appl Environ Microbiol 78 : 4083 4091.[PubMed] [CrossRef]
36. Grauke LJ,, Kudva IT,, Yoon JW,, Hunt CW,, Williams CJ,, Hovde CJ . 2002. Gastrointestinal tract location of Escherichia coli O157:H7 in ruminants. Appl Environ Microbiol 68 : 2269 2277.[PubMed] [CrossRef]
37. Woodward MJ,, Best A,, Sprigings KA,, Pearson GR,, Skuse AM,, Wales A,, Hayes CM,, Roe JM,, Low JC,, La Ragione RM . 2003. Non-toxigenic Escherichia coli O157:H7 strain NCTC12900 causes attaching-effacing lesions and eae-dependent persistence in weaned sheep. Int J Med Microbiol 293 : 299 308.[PubMed] [CrossRef]
38. Best A,, Clifford D,, Crudgington B,, Cooley WA,, Nunez A,, Carter B,, Weyer U,, Woodward MJ,, La Ragione RM . 2009. Intermittent Escherichia coli O157:H7 colonisation at the terminal rectum mucosa of conventionally-reared lambs. Vet Res 40 : 9. [PubMed] [CrossRef]
39. Beutin L,, Geier D,, Steinruck H,, Zimmermann S,, Scheutz F . 1993. Prevalence and some properties of verotoxin (Shiga-like toxin)-producing Escherichia coli in seven different species of healthy domestic animals. J Clin Microbiol 31 : 2483 2488.[PubMed]
40. Cortes C,, De la Fuente R,, Blanco J,, Blanco M,, Blanco JE,, Dhabi G,, Mora A,, Justel P,, Contreras A,, Sanchez A,, Corrales JC,, Orden JA . 2005. Serotypes, virulence genes and intimin types of verotoxin-producing Escherichia coli and enteropathogenic E. coli isolated from healthy dairy goats in Spain. Vet Microbiol 110 : 67 76.[PubMed] [CrossRef]
41. Heuvelink AE,, van Heerwaarden C,, Zwartkruis-Nahuis JT,, van Oosterom R,, Edink K,, van Duynhoven YT,, de Boer E . 2002. Escherichia coli O157 infection associated with a petting zoo. Epidemiol Infect 129 : 295 302.[PubMed] [CrossRef]
42. LeJeune JT,, Davis MA . 2004. Outbreaks of zoonotic enteric disease associated with animal exhibits. J Am Vet Med Assoc 224 : 1440 1445.[PubMed] [CrossRef]
43. Schilling AK,, Hotzel H,, Methner U,, Sprague LD,, Schmoock G,, El-Adawy H,, Ehricht R,, Wohr AC,, Erhard M,, Geue L . 2012. Zoonotic agents in small ruminants kept on city farms in southern Germany. Appl Environ Microbiol 78 : 3785 3793.[PubMed] [CrossRef]
44. Espie E,, Vaillant V,, Mariani-Kurkdjian P,, Grimont F,, Martin-Schaller R,, De Valk H,, Vernozy-Rozand C . 2006. Escherichia coli O157 outbreak associated with fresh unpasteurized goats’ cheese. Epidemiol Infect 134 : 143 146.[PubMed] [CrossRef]
45. Duffy LL,, Small A,, Fegan N . 2010. Concentration and prevalence of Escherichia coli O157 and Salmonella serotypes in sheep during slaughter at two Australian abattoirs. Aust Vet J 88 : 399 404.[PubMed] [CrossRef]
46. Djordjevic SP,, Hornitzky MA,, Bailey G,, Gill P,, Vanselow B,, Walker K,, Bettelheim KA . 2001. Virulence properties and serotypes of Shiga toxin-producing Escherichia coli from healthy Australian slaughter-age sheep. J Clin Microbiol 39 : 2017 2021.[PubMed] [CrossRef]
47. Oporto B,, Esteban JI,, Aduriz G,, Juste RA,, Hurtado A . 2008. Escherichia coli O157:H7 and non-O157 Shiga toxin-producing E. coli in healthy cattle, sheep and swine herds in Northern Spain. Zoonoses Public Health 55 : 73 81.[PubMed] [CrossRef]
48. Jacob ME,, Foster DM,, Rogers AT,, Balcomb CC,, Shi X,, Nagaraja TG . 2013. Evidence of non-O157 Shiga toxin-Producing Escherichia coli in the feces of meat goats at a U.S. slaughter plant. J Food Prot 76 : 1626 1629.[PubMed] [CrossRef]
49. Jacob ME,, Foster DM,, Rogers AT,, Balcomb CC,, Sanderson MW . 2013. Prevalence and relatedness of Escherichia coli O157:H7 strains in the feces and on the hides and carcasses of U.S. meat goats at slaughter. Appl Environ Microbiol 79 : 4154 4158.[PubMed] [CrossRef]
50. Solecki O,, MacRae M,, Strachan N,, Lindstedt BA,, Ogden I . 2009. E. coli O157 from sheep in northeast Scotland: prevalence, concentration shed, and molecular characterization by multilocus variable tandem repeat analysis. Foodborne Pathog Dis 6 : 849 854.[PubMed] [CrossRef]
51. Milnes AS,, Stewart I,, Clifton-Hadley FA,, Davies RH,, Newell DG,, Sayers AR,, Cheasty T,, Cassar C,, Ridley A,, Cook AJ,, Evans SJ,, Teale CJ,, Smith RP,, McNally A,, Toszeghy M,, Futter R,, Kay A,, Paiba GA . 2008. Intestinal carriage of verocytotoxigenic Escherichia coli O157, Salmonella, thermophilic Campylobacter and Yersinia enterocolitica, in cattle, sheep and pigs at slaughter in Great Britain during 2003. Epidemiol Infect 136 : 739 751.[PubMed] [CrossRef]
52. Heuvelink AE,, van den Biggelaar FL,, de Boer E,, Herbes RG,, Melchers WJ,, Huis in 't Veld JH,, Monnens LA . 1998. Isolation and characterization of verocytotoxin-producing Escherichia coli O157 strains from Dutch cattle and sheep. J Clin Microbiol 36 : 878 882.[PubMed]
53. Vu-Khac H,, Cornick NA . 2008. Prevalence and genetic profiles of Shiga toxin-producing Escherichia coli strains isolated from buffaloes, cattle, and goats in central Vietnam. Vet Microbiol 126 : 356 363.[PubMed] [CrossRef]
54. Islam MA,, Mondol AS,, de Boer E,, Beumer RR,, Zwietering MH,, Talukder KA,, Heuvelink AE . 2008. Prevalence and genetic characterization of shiga toxin-producing Escherichia coli isolates from slaughtered animals in Bangladesh. Appl Environ Microbiol 74 : 5414 5421.[PubMed] [CrossRef]
55. Effler E,, Isaacson M,, Arntzen L,, Heenan R,, Canter P,, Barrett T,, Lee L,, Mambo C,, Levine W,, Zaidi A,, Griffin PM . 2001. Factors contributing to the emergence of Escherichia coli O157 in Africa. Emerg Infect Dis 7 : 812 819.[PubMed] [CrossRef]
56. Cunin P,, Tedjouka E,, Germani Y,, Ncharre C,, Bercion R,, Morvan J,, Martin P . 1999. An epidemic of bloody diarrhea: Escherichia coli O157 emerging in Cameroon? Emerg Infect Dis 5 : 285. [PubMed] [CrossRef]
57. Battisti A,, Lovari S,, Franco A,, Di Egidio A,, Tozzoli R,, Caprioli A,, Morabito S . 2006. Prevalence of Escherichia coli O157 in lambs at slaughter in Rome, central Italy. Epidemiol Infect 134 : 415 419.[PubMed] [CrossRef]
58. Franco A,, Lovari S,, Cordaro G,, Di Matteo P,, Sorbara L,, Iurescia M,, Donati V,, Buccella C,, Battisti A . 2009. Prevalence and concentration of verotoxigenic Escherichia coli O157:H7 in adult sheep at slaughter from Italy. Zoonoses Public Health 56 : 215 220.[PubMed] [CrossRef]
59. Orden JA,, Cortes C,, Horcajo P,, De la Fuente R,, Blanco JE,, Mora A,, Lopez C,, Blanco J,, Contreras A,, Sanchez A,, Corrales JC,, Dominguez-Bernal G . 2008. A longitudinal study of verotoxin-producing Escherichia coli in two dairy goat herds. Vet Microbiol 132 : 428 434.[PubMed] [CrossRef]
60. Kudva IT,, Hatfield PG,, Hovde CJ . 1996. Escherichia coli O157:H7 in microbial flora of sheep. J Clin Microbiol 34 : 431 433.[PubMed]
61. Galiero G,, Conedera G,, Alfano D,, Caprioli A . 2005. Isolation of verocytotoxin-producing Escherichia coli O157 from water buffaloes ( Bubalus bubalis) in southern Italy. Vet Rec 156 : 382 383.[PubMed]
62. Sargeant JM,, Hafer DJ,, Gillespie JR,, Oberst RD,, Flood SJ . 1999. Prevalence of Escherichia coli O157:H7 in white-tailed deer sharing rangeland with cattle. J Am Vet Med Assoc 215 : 792 794.[PubMed]
63. Dunn JR,, Keen JE,, Moreland D,, Alex T . 2004. Prevalence of Escherichia coli O157:H7 in white-tailed deer from Louisiana. J Wildl Dis 40 : 361 365.[PubMed] [CrossRef]
64. French E,, Rodriguez-Palacios A,, LeJeune JT . 2010. Enteric bacterial pathogens with zoonotic potential isolated from farm-raised deer. Foodborne Pathog Dis 7 : 1031 1037.[PubMed] [CrossRef]
65. Bardiau M,, Gregoire F,, Muylaert A,, Nahayo A,, Duprez JN,, Mainil J,, Linden A . 2010. Enteropathogenic (EPEC), enterohaemorragic (EHEC) and verotoxigenic (VTEC) Escherichia coli in wild cervids. J Appl Microbiol 109 : 2214 2222.[PubMed] [CrossRef]
66. Sanchez S,, Garcia-Sanchez A,, Martinez R,, Blanco J,, Blanco JE,, Blanco M,, Dahbi G,, Mora A,, Hermoso de Mendoza J,, Alonso JM,, Rey J . 2009. Detection and characterisation of Shiga toxin-producing Escherichia coli other than Escherichia coli O157:H7 in wild ruminants. Vet J 180 : 384 388.[PubMed] [CrossRef]
67. Kistler WM,, Mulugeta S,, Mauro SA . 2011. Detection of stx and stx genes in Pennsylvanian white-tailed deer. Toxins (Basel) 3 : 640 646.[PubMed] [CrossRef]
68. Renter DG,, Sargeant JM,, Hygnstorm SE,, Hoffman JD,, Gillespie JR . 2001. Escherichia coli O157:H7 in free-ranging deer in Nebraska. J Wildl Dis 37 : 755 760.[PubMed] [CrossRef]
69. Rice DH,, Hancock DD,, Besser TE . 2003. Faecal culture of wild animals for Escherichia coli O157:H7. Vet Rec 152 : 82 83.[PubMed] [CrossRef]
70. Keene WE,, Sazie E,, Kok J,, Rice DH,, Hancock DD,, Balan VK,, Zhao T,, Doyle MP . 1997. An outbreak of Escherichia coli O157:H7 infections traced to jerky made from deer meat. JAMA 277 : 1229 1231.[PubMed] [CrossRef]
71. Rounds JM,, Rigdon CE,, Muhl LJ,, Forstner M,, Danzeisen GT,, Koziol BS,, Taylor C,, Shaw BT,, Short GL,, Smith KE . 2012. Non-O157 Shiga toxin-producing Escherichia coli associated with venison. Emerg Infect Dis 18 : 279 282.[PubMed] [CrossRef]
72. Laidler MR,, Tourdjman M,, Buser GL,, Hostetler T,, Repp KK,, Leman R,, Samadpour M,, Keene WE . 2013. Escherichia coli O157:H7 infections associated with consumption of locally grown strawberries contaminated by deer. Clin Infect Dis 57 : 1129 1134.[PubMed] [CrossRef]
73. Franklin AB,, Vercauteren KC,, Maguire H,, Cichon MK,, Fischer JW,, Lavelle MJ,, Powell A,, Root JJ,, Scallan E . 2013. Wild ungulates as disseminators of Shiga toxin-producing Escherichia coli in urban areas. PloS One 8 : e81512. [PubMed] [CrossRef]
74. Kudva IT,, Stasko JA . 2013. Bison and bovine rectoanal junctions exhibit similar cellular architecture and Escherichia coli O157 adherence patterns. BMC Vet Res 9 : 266. [PubMed] [CrossRef]
75. Johnson K . 2011. Plains giants have foothold on tables. The New York Times, Jan. 23: A16. http://www.nytimes.com/2011/01/23/us/23buffalo.html?_r=0.
76. Reinstein S,, Fox JT,, Shi X,, Alam MJ,, Nagaraja TG . 2007. Prevalence of Escherichia coli O157:H7 in the American bison ( Bison bison). J Food Prot 70 : 2555 2560.[PubMed]
77. Li Q,, Sherwood JS,, Logue CM . 2004. The prevalence of Listeria, Salmonella, Escherichia coli and E. coli O157:H7 on bison carcasses during processing. Food Microbiol 21 : 791 799.[CrossRef]
78. Magwedere K,, Dang HA,, Mills EW,, Cutter CN,, Roberts EL,, Debroy C . 2013. Incidence of Shiga toxin-producing Escherichia coli strains in beef, pork, chicken, deer, boar, bison, and rabbit retail meat. J Vet Diagn Invest 25 : 254 258.[PubMed] [CrossRef]
79. Mercado EC,, Rodriguez SM,, Elizondo AM,, Marcoppido G,, Parreño V . 2004. Isolation of Shiga toxin-producing Escherichia coli from a South American camelid ( Lama guanicoe) with diarrhea. J Clin Microbiol 42 : 4809 4811.[PubMed] [CrossRef]
80. Gilbreath JJ,, Shields MS,, Smith RL,, Farrell LD,, Sheridan PP,, Spiegel KM . 2009. Shiga toxins, and the genes encoding them, in fecal samples from native Idaho ungulates. Appl Environ Microbiol 75 : 862 865.[PubMed] [CrossRef]
81. Cid D,, Martín-Espada C,, Maturrano L,, García A,, Luna L,, Rosadio R, . 2012. Diarrheagenic Escherichia coli strains isolated from neonatal Peruvian alpacas ( Vicugnapacos) with diarrhea, p 223 228. In Pérez-Cabal MA,, Gutiérrez JP,, Cervantes I,, Alcalde MJ (ed), Fibre Production in South American Camelids and Other Fibre Animals. Wageningen Academic Publishers, Wageningen, The Netherlands.
82. Mohammed Hamzah A,, Mohammed Hussein A,, Mahmoud Khalef J . 2013. Isolation of Escherichia coli 0157:H7 strain from fecal samples of zoo animal. Scientific World Journal 2013 : 843968. [PubMed] [CrossRef]
83. Leotta GA,, Deza N,, Origlia J,, Toma C,, Chinen I,, Miliwebsky E,, Iyoda S,, Sosa-Estani S,, Rivas M . 2006. Detection and characterization of Shiga toxin-producing Escherichia coli in captive non-domestic mammals. Vet Microbiol 118 : 151 157.[PubMed] [CrossRef]
84. Chandran A,, Mazumder A . 2013. Prevalence of diarrhea-associated virulence genes and genetic diversity in Escherichia coli isolates from fecal material of various animal hosts. Appl Environ Microbiol 79 : 7371 7380.[PubMed] [CrossRef]
85. Hancock DD,, Besser TE,, Rice DH,, Ebel ED,, Herriott DE,, Carpenter LV . 1998. Multiple sources of Escherichia coli O157 in feedlots and dairy farms in the northwestern USA. Prev Vet Med 35 : 11 19.[PubMed] [CrossRef]
86. Larson DG . 2009. Prevalence of Shiga toxin-producing Escherichia coli in the Sacramento Valley equine population. M.S. thesis, California State University, Sacramento.
87. Lengacher B,, Kline TR,, Harpster L,, Williams ML,, Lejeune JT . 2010. Low prevalence of Escherichia coli O157:H7 in horses in Ohio, USA. J Food Prot 73 : 2089 2092.[PubMed]
88. Pichner R,, Sander A,, Steinruck H,, Gareis M . 2005. [Occurrence of Salmonella spp. and shigatoxin-producing Escherichia coli (STEC) in horse faeces and horse meat products]. Berl Munch Tierarztl Wochenschr 118 : 321 325 (In German).[PubMed]
89. Pritchard GC,, Smith R,, Ellis-Iversen J,, Cheasty T,, Willshaw GA . 2009. Verocytotoxigenic Escherichia coli O157 in animals on public amenity premises in England and Wales, 1997 to 2007. Vet Rec 164 : 545 549.[PubMed] [CrossRef]
90. Momtaz H,, Farzan R,, Rahimi E,, Safarpoor Dehkordi F,, Souod N . 2012. Molecular characterization of Shiga toxin-producing Escherichia coli isolated from ruminant and donkey raw milk samples and traditional dairy products in Iran. Scientific World Journal 2012 : 231 341.[PubMed] [CrossRef]
91. Chalmers RM,, Salmon RL,, Willshaw GA,, Cheasty T,, Looker N,, Davies I,, Wray C . 1997. Vero-cytotoxin-producing Escherichia coli O157 in a farmer handling horses. Lancet 349 : 1816. [PubMed] [CrossRef]
92. Ferens WA,, Hovde CJ . 2011. Escherichia coli O157:H7: animal reservoir and sources of human infection. Foodborne Pathog Dis 8 : 465 487.[PubMed] [CrossRef]
93. Kaufmann M,, Zweifel C,, Blanco M,, Blanco JE,, Blanco J,, Beutin L,, Stephan R . 2006. Escherichia coli O157 and non-O157 Shiga toxin-producing Escherichia coli in fecal samples of finished pigs at slaughter in Switzerland. J Food Prot 69 : 260 266.[PubMed]
94. Chapman PA,, Siddons CA,, Gerdan Malo AT,, Harkin MA . 1997. A 1-year study of Escherichia coli O157 in cattle, sheep, pigs and poultry. Epidemiol Infect 119 : 245 250.[PubMed] [CrossRef]
95. Richards HA,, Perez-Conesa D,, Doane CA,, Gillespie BE,, Mount JR,, Oliver SP,, Pangloli P,, Draughon FA . 2006. Genetic characterization of a diverse Escherichia coli O157:H7 population from a variety of farm environments. Foodborne Pathog Dis 3 : 259 265.[PubMed] [CrossRef]
96. Waddell TE,, Coomber BL,, Gyles CL . 1998. Localization of potential binding sites for the edema disease verotoxin (VT2e) in pigs. Can J Vet Res 62 : 81 86.[PubMed]
97. Fratamico PM,, Bagi LK,, Bush EJ,, Solow BT . 2004. Prevalence and characterization of shiga toxin-producing Escherichia coli in swine feces recovered in the National Animal Health Monitoring System’s Swine 2000 study. Appl Environ Microbiol 70 : 7173 7178.[PubMed] [CrossRef]
98. Imberechts H,, De Greve H,, Lintermans P . 1992. The pathogenesis of edema disease in pigs. A review. Vet Microbiol 31 : 221 233.[PubMed] [CrossRef]
99. Müthing J,, Meisen I,, Zhang W,, Bielaszewska M,, Mormann M,, Bauerfeind R,, Schmidt MA,, Friedrich AW,, Karch H . 2012. Promiscuous Shiga toxin 2e and its intimate relationship to Forssman. Glycobiology 22 : 849 862.[PubMed] [CrossRef]
100. Meisen I,, Rosenbrück R,, Galla HJ,, Hüwel S,, Kouzel IU,, Mormann M,, Karch H,, Müthing J . 2013. Expression of Shiga toxin 2e glycosphingolipid receptors of primary porcine brain endothelial cells and toxin-mediated breakdown of the blood-brain barrier. Glycobiology 23 : 745 759.[PubMed] [CrossRef]
101. Booher SL,, Cornick NA,, Moon HW . 2002. Persistence of Escherichia coli O157:H7 in experimentally infected swine. Vet Microbiol 89 : 69 81.[PubMed] [CrossRef]
102. Trotz-Williams LA,, Mercer NJ,, Walters JM,, Maki AM,, Johnson RP . 2012. Pork implicated in a Shiga toxin-producing Escherichia coli O157:H7 outbreak in Ontario, Canada. Can J Public Health 103 : e622 e326.[PubMed]
103. Jay MT,, Cooley M,, Carychao D,, Wiscomb GW,, Sweitzer RA,, Crawford-Miksza L,, Farrar JA,, Lau DK,, O’Connell J,, Millington A,, Asmundson RV,, Atwill ER,, Mandrell RE . 2007. Escherichia coli O157:H7 in feral swine near spinach fields and cattle, central California coast. Emerg Infect Dis 13 : 1908 1911.[PubMed] [CrossRef]
104. Wacheck S,, Fredriksson-Ahomaa M,, Konig M,, Stolle A,, Stephan R . 2010. Wild boars as an important reservoir for foodborne pathogens. Foodborne Pathog Dis 7 : 307 312.[PubMed] [CrossRef]
105. Sanchez S,, Martinez R,, Garcia A,, Vidal D,, Blanco J,, Blanco M,, Blanco JE,, Mora A,, Herrera-Leon S,, Echeita A,, Alonso JM,, Rey J . 2010. Detection and characterisation of O157:H7 and non-O157 Shiga toxin-producing Escherichia coli in wild boars. Vet Microbiol 143 : 420 423.[PubMed] [CrossRef]
106. Wallace JS,, Cheasty T,, Jones K . 1997. Isolation of vero cytotoxin-producing Escherichia coli O157 from wild birds. J Appl Microbiol 82 : 399 404.[PubMed] [CrossRef]
107. Pedersen K,, Clark L . 2007. A review of Shiga toxin Escherichia coli and Salmonella enterica in cattle and free-ranging birds: potential association and epidemiological links. Human–Wildlife Conflicts 1 : 68 77.
108. Nielsen EM,, Skov MN,, Madsen JJ,, Lodal J,, Jespersen JB,, Baggesen DL . 2004. Verocytotoxin-producing Escherichia coli in wild birds and rodents in close proximity to farms. Appl Environ Microbiol 70 : 6944 6947.[PubMed] [CrossRef]
109. Hughes LA,, Bennett M,, Coffey P,, Elliott J,, Jones TR,, Jones RC,, Lahuerta-Marin A,, McNiffe K,, Norman D,, Williams NJ,, Chantrey J . 2009. Risk factors for the occurrence of Escherichia coli virulence genes eae, stx1 and stx2 in wild bird populations. Epidemiol Infect 137 : 1574 1582.[PubMed] [CrossRef]
110. LeJeune J,, Homan J,, Linz G,, Pearl DL, . 2008. Role of the European starling in the transmission of E. coli O157 on dairy farms, p 31 34. In Timm RM,, Madon MB (ed), Proceedings of the Twenty-Third Vertebrate Pest Conference. University of California, Davis, CA.
111. Foster G,, Evans J,, Knight HI,, Smith AW,, Gunn GJ,, Allison LJ,, Synge BA,, Pennycott TW . 2006. Analysis of feces samples collected from a wild-bird garden feeding station in Scotland for the presence of verocytotoxin-producing Escherichia coli O157. Appl Environ Microbiol 72 : 2265 2267.[PubMed] [CrossRef]
112. Kobayashi H,, Kanazaki M,, Hata E,, Kubo M . 2009. Prevalence and characteristics of eae- and stx-positive strains of Escherichia coli from wild birds in the immediate environment of Tokyo Bay. Appl Environ Microbiol 75 : 292 295.[PubMed] [CrossRef]
113. Kauffman MD,, LeJeune J . 2011. European starlings ( Sturnus vulgaris) challenged with Escherichia coli O157 can carry and transmit the human pathogen to cattle. Lett Appl Microbiol 53 : 596 601.[PubMed] [CrossRef]
114. Williams ML,, Pearl DL,, Lejeune JT . 2011. Multiple-locus variable-nucleotide tandem repeat subtype analysis implicates European starlings as biological vectors for Escherichia coli O157:H7 in Ohio, USA. J Appl Microbiol 111 : 982 988.[PubMed] [CrossRef]
115. Cernicchiaro N,, Pearl DL,, McEwen SA,, Harpster L,, Homan HJ,, Linz GM,, Lejeune JT . 2012. Association of wild bird density and farm management factors with the prevalence of E. coli O157 in dairy herds in Ohio (2007–2009). Zoonoses Public Health 59 : 320 329.[PubMed] [CrossRef]
116. Morabito S,, Dell’Omo G,, Agrimi U,, Schmidt H,, Karch H,, Cheasty T,, Caprioli A . 2001. Detection and characterization of Shiga toxin-producing Escherichia coli in feral pigeons. Vet Microbiol 82 : 275 283.[PubMed] [CrossRef]
117. Moriarty EM,, Weaver L,, Sinton LW,, Gilpin B . 2012. Survival of Escherichia coli, enterococci and Campylobacter jejuni in Canada goose faeces on pasture. Zoonoses Public Health 59 : 490 497.[PubMed] [CrossRef]
118. Kirschner AK,, Zechmeister TC,, Kavka GG,, Beiwl C,, Herzig A,, Mach RL,, Farnleitner AH . 2004. Integral strategy for evaluation of fecal indicator performance in bird-influenced saline inland waters. Appl Environ Microbiol 70 : 7396 7403.[PubMed] [CrossRef]
119. Kullas H,, Coles M,, Rhyan J,, Clark L . 2002. Prevalence of Escherichia coli serogroups and human virulence factors in faeces of urban Canada geese ( Branta canadensis). Int J Environ Health Res 12 : 153 162.[PubMed] [CrossRef]
120. Murinda SE,, Nguyen LT,, Nam HM,, Almeida RA,, Headrick SJ,, Oliver SP . 2004. Detection of sorbitol-negative and sorbitol-positive Shiga toxin-producing Escherichia coli, Listeria monocytogenes, Campylobacter jejuni, and Salmonella spp. in dairy farm environmental samples. Foodborne Pathog Dis 1 : 97 104.[PubMed] [CrossRef]
121. Rutledge ME,, Siletzky RM,, Gu W,, Degernes LA,, Moorman CE,, DePerno CS,, Kathariou S . 2013. Characterization of Campylobacter from resident Canada geese in an urban environment. J Wildl Dis 49 : 1 9.[PubMed] [CrossRef]
122. Siembieda JL,, Miller WA,, Byrne BA,, Ziccardi MH,, Anderson N,, Chouicha N,, Sandrock CE,, Johnson CK . 2011. Zoonotic pathogens isolated from wild animals and environmental samples at two California wildlife hospitals. J Am Vet Med Assoc 238 : 773 783.[PubMed] [CrossRef]
123. Bedard J,, Gauthier G . 1986. Assessment of faecal output in geese. J Appl Ecol 23 : 77 90.[CrossRef]
124. Ankney CD . 1996. An embarrassment of riches: too many geese. J Wildl Managet 60 : 217 223.[CrossRef]
125. Doyle MP,, Schoeni JL . 1987. Isolation of Escherichia coli O157:H7 from retail fresh meats and poultry. Appl Environ Microbiol 53 : 2394 2396.[PubMed]
126. Doane CA,, Pangloli P,, Richards HA,, Mount JR,, Golden DA,, Draughon FA . 2007. Occurrence of Escherichia coli O157:H7 in diverse farm environments. J Food Prot 70 : 6 10.[PubMed]
127. Schoeni JL,, Doyle MP . 1994. Variable colonization of chickens perorally inoculated with Escherichia coli O157:H7 and subsequent contamination of eggs. Appl Environ Microbiol 60 : 2958 2962.[PubMed]
128. Gholami-Ahangaran M,, Zia-Jahromi N . 2012. Identification of Shiga toxin and intimin genes in Escherichia coli detected from canary ( Serinus canaria domestica). Toxicol Ind Health Oct 9. [PubMed]
129. Tuyet DT,, Yassibanda S,, Nguyen Thi PL,, Koyenede MR,, Gouali M,, Bekondi C,, Mazzi J,, Germani Y . 2006. Enteropathogenic Escherichia coli o157 in Bangui and N’Goila, Central African Republic: a brief report. Am J Trop Med Hyg 75 : 513 515.[PubMed]
130. Guyon R,, Dorey F,, Collobert JF,, Foret J,, Goubert C,, Mariau V,, Malas JP . 2000. Detection of Shiga toxin-producing Escherichia coli O157 in shellfish ( Crassostrea gigas). Sciences des Aliments 20 : 457 466.[CrossRef]
131. Surendraraj A,, Thampuran N,, Joseph TC . 2010. Molecular screening, isolation, and characterization of enterohemorrhagic Escherichia coli O157:H7 from retail shrimp. J Food Prot 73 : 97 103.[PubMed]
132. Sanath Kumar H,, Otta SK,, Karunasagar I,, Karunasagar I . 2001. Detection of Shiga-toxigenic Escherichia coli (STEC) in fresh seafood and meat marketed in Mangalore, India by PCR. Lett Appl Microbiol 33 : 334 338.[PubMed] [CrossRef]
133. Thampuran N,, Surendraraj A,, Surendran PK . 2005. Prevalence and characterization of typical and atypical Escherichia coli from fish sold at retail in Cochin, India. J Food Prot 68 : 2208 2211.[PubMed]
134. Gupta B,, Ghatak S,, Gill JPS . 2013. Incidence and virulence properties of E. coli isolated from fresh fish and ready-to-eat fish products. Vet World 6 : 5 9.[CrossRef]
135. Gourmelon M,, Montet MP,, Lozach S,, Le Mennec C,, Pommepuy M,, Beutin L,, Vernozy-Rozand C . 2006. First isolation of Shiga toxin 1d producing Escherichia coli variant strains in shellfish from coastal areas in France. J Appl Microbiol 100 : 85 97.[PubMed] [CrossRef]
136. Kilonzo C,, Li X,, Vivas EJ,, Jay-Russell MT,, Fernandez KL,, Atwill ER . 2013. Fecal shedding of zoonotic food-borne pathogens by wild rodents in a major agricultural region of the central California coast. Appl Environ Microbiol 79 : 6337 6344.[PubMed] [CrossRef]
137. Cizek A,, Alexa P,, Literak I,, Hamrik J,, Novak P,, Smola J . 1999. Shiga toxin-producing Escherichia coli O157 in feedlot cattle and Norwegian rats from a large-scale farm. Lett Appl Microbiol 28 : 435 439.[PubMed] [CrossRef]
138. Blanco Crivelli X,, Rumi MV,, Carfagnini JC,, Degregorio O,, Bentancor AB . 2012. Synanthropic rodents as possible reservoirs of shigatoxigenic Escherichia coli strains. Front Cell Infect Microbiol 2 : 134. [PubMed] [CrossRef]
139. Cizek A,, Literak I,, Scheer P . 2000. Survival of Escherichia coli O157 in faeces of experimentally infected rats and domestic pigeons. Lett Appl Microbiol 31 : 349 352.[PubMed] [CrossRef]
140. Nkogwe C,, Raletobana J,, Stewart-Johnson A,, Suepaul S,, Adesiyun A . 2011. Frequency of detection of Escherichia coli, Salmonella spp., and Campylobacter spp. in the faeces of wild rats ( Rattus spp.) in Trinidad and Tobago. Vet Med Int 2011 : 686 923.[PubMed] [CrossRef]
141. Mohawk KL,, O’Brien AD . 2011. Mouse models of Escherichia coli O157:H7 infection and Shiga toxin injection. J Biomed Biotechnol 2011 : 258185.[PubMed] [CrossRef]
142. Wadolkowski EA,, Burris JA,, O’Brien AD . 1990. Mouse model for colonization and disease caused by enterohemorrhagic Escherichia coli O157: H7. Infect Immun 58 : 2438 2445.[PubMed]
143. Pritchard GC,, Williamson S,, Carson T,, Bailey JR,, Warner L,, Willshaw G,, Cheasty T . 2001. Wild rabbits—a novel vector for verocytotoxigenic Escherichia coli O157. Vet Rec 149 : 567. [PubMed]
144. Scaife HR,, Cowan D,, Finney J,, Kinghorn-Perry SF,, Crook B . 2006. Wild rabbits ( Oryctolagus cuniculus) as potential carriers of verocytotoxin-producing Escherichia coli . Vet Rec 159 : 175 178.[PubMed] [CrossRef]
145. Garcia A,, Fox JG . 2003. The rabbit as a new reservoir host of enterohemorrhagic Escherichia coli . Emerg Infect Dis 9 : 1592 1597.[PubMed] [CrossRef]
146. Panda A,, Tatarov I,, Melton-Celsa AR,, Kolappaswamy K,, Kriel EH,, Petkov D,, Coksaygan T,, Livio S,, McLeod CG,, Nataro JP,, O’Brien AD,, DeTolla LJ . 2010. Escherichia coli O157:H7 infection in Dutch belted and New Zealand white rabbits. Comp Med 60 : 31 37.[PubMed]
147. Dalle Zotte A,, Szendrő Z . 2011. The role of rabbit meat as functional food. Meat Sci 88 : 319 331.[PubMed] [CrossRef]
148. Cook AJ,, McCobb E . 2012. Quantifying the shelter rabbit population: an analysis of Massachusetts and Rhode Island animal shelters. J Appl Anim WelfSci 15 : 297 312.[PubMed] [CrossRef]
149. Compton JA,, Baney JA,, Donaldson SC,, Houser BA,, San Julian GJ,, Yahner RH,, Chmielecki W,, Reynolds S,, Jayarao BM . 2008. Salmonella infections in the common raccoon ( Procyon lotor) in western Pennsylvania. J Clin Microbiol 46 : 3084 3086.[PubMed] [CrossRef]
150. Lee K,, Iwata T,, Nakadai A,, Kato T,, Hayama S,, Taniguchi T,, Hayashidani H . 2011. Prevalence of Salmonella, Yersinia and Campylobacter spp. in feral raccoons ( Procyonlotor) and masked palm civets ( Paguma larvata) in Japan. Zoonoses Public Health 58 : 424 431.[PubMed] [CrossRef]
151. Beltrán-Beck B,, García F,, Gortázar C . 2012. Raccoons in Europe: disease hazards due to the establishment of an invasive species. Eur J Wildl Res 58 : 5 15.[CrossRef]
152. Shere JA,, Bartlett KJ,, Kaspar CW . 1998. Longitudinal study of Escherichia coli O157:H7 dissemination on four dairy farms in Wisconsin. Appl Environ Microbiol 64 : 1390 1399.[PubMed]
153. Renter DG,, Sargeant JM,, Oberst RD,, Samadpour M . 2003. Diversity, frequency, and persistence of Escherichia coli O157 strains from range cattle environments. Appl Environ Microbiol 69 : 542 547.[PubMed] [CrossRef]
154. Jay-Russell M,, Atwill E,, Cooley M,, Carychao D,, Vivas E,, Chandler S,, Orthmeyer D,, Lii X,, Mandrell R . 2010, p 23 27. Occurrence of Escherichia coli O157:H7 in wildlife in a major produce production region in California. Poster. 110th Gen Meet Am Soc for Microbiol. American Society for Microbiology, Washington, DC.
155. Alam MJ,, Zurek L . 2004. Association of E scherichia coli O157:H7 with houseflies on a cattle farm. Appl Environ Microbiol 70 : 7578 7580.[PubMed] [CrossRef]
156. Keen JE,, Wittum TE,, Dunn JR,, Bono JL,, Durso LM . 2006. Shiga-toxigenic Escherichia coli O157 in agricultural fair livestock, United States. Emerg Infect Dis 12 : 780 786.[PubMed] [CrossRef]
157. Xu J,, Liu Q,, Jing H,, Pang B,, Yang J,, Zhao G,, Li H . 2003. Isolation of Escherichia coli O157: H7 from dung beetles Catharsius molossus . Microbiol Immunol 47 : 45 49.[PubMed] [CrossRef]
158. Szalanski A,, Owens C,, McKay T,, Steelman C . 2004. Detection of Campylobacter and Escherichia coli O157: H7 from filth flies by polymerase chain reaction. Med Vet Entomol 18 : 241 246.[PubMed] [CrossRef]
159. Kobayashi M,, Sasaki T,, Saito N,, Tamura K,, Suzuki K,, Watanabe H,, Agui N . 1999. Houseflies: not simple mechanical vectors of enterohemorrhagic Escherichia coli O157:H7. Am J Trop Med Hyg 61 : 625 629.[PubMed]
160. Ahmad A,, Nagaraja TG,, Zurek L . 2007. Transmission of Escherichia coli O157:H7 to cattle by house flies. Prev Vet Med 80 : 74 81.[PubMed] [CrossRef]
161. Wasala L,, Talley JL,, Desilva U,, Fletcher J,, Wayadande A . 2013. Transfer of Escherichia coli O157:H7 to spinach by house flies, Musca domestica ( Diptera: Muscidae). Phytopathology 103 : 373 380.[PubMed] [CrossRef]
162. Pickens L,, Morgan N,, Hartsock J,, Smith J . 1967. Dispersal patterns and populations of the house fly affected by sanitation and weather in rural Maryland. J Econ Entomol 60 : 1250 1255.
163. Roopnarine RR,, Ammons D,, Rampersad J,, Adesiyun AA . 2007. Occurrence and characterization of verocytotoxigenic Escherichia coli (VTEC) strains from dairy farms in Trinidad. Zoonoses Public Health 54 : 78 85.[PubMed] [CrossRef]
164. LeJeune JT,, Hancock DD . 2001. Public health concerns associated with feeding raw meat diets to dogs. J Am Vet Med Assoc 219 : 1222 1225.[PubMed] [CrossRef]
165. Hogg RA,, Holmes JP,, Ghebrehewet S,, Elders K,, Hart J,, Whiteside C,, Willshaw GA,, Cheasty T,, Kay A,, Lynch K,, Pritchard GC . 2009. Probable zoonotic transmission of verocytotoxigenic Escherichia coli O 157 by dogs. Vet Rec 164 : 304 305.[PubMed] [CrossRef]
166. Beutin L . 1999. Escherichia coli as a pathogen in dogs and cats. Vet Res 30 : 285 298.[PubMed]
167. Bentancor A,, Rumi MV,, Carbonari C,, Gerhardt E,, Larzabal M,, Vilte DA,, Pistone-Creydt V,, Chinen I,, Ibarra C,, Cataldi A,, Mercado EC . 2012. Profile of Shiga toxin-producing Escherichia coli strains isolated from dogs and cats and genetic relationships with isolates from cattle, meat and humans. Vet Microbiol 156 : 336 342.[PubMed] [CrossRef]
168. Anonymous . 2011. Dog show sparks new Swedish EHEC outbreak, The Local, June 16 http://www.thelocal.se/20110616/34384.
169. Mora A,, Lopez C,, Dhabi G,, Lopez-Beceiro AM,, Fidalgo LE,, Diaz EA,, Martinez-Carrasco C,, Mamani R,, Herrera A,, Blanco JE,, Blanco M,, Blanco J . 2012. Seropathotypes, phylogroups, Stx subtypes, and intimin types of wildlife-carried, Shiga toxin-producing Escherichia coli strains with the same characteristics as human-pathogenic isolates. Appl Environ Microbiol 78 : 2578 2585.[PubMed] [CrossRef]
170. Rumi MV,, Irino K,, Deza N,, Huguet MJ,, Bentancor AB . 2012. First isolation in Argentina of a highly virulent Shiga toxin-producing Escherichia coli O145:NM from a domestic cat. J Infect Dev Ctries 6 : 358 363.[PubMed]
171. Busch U,, Hormansdorfer S,, Schranner S,, Huber I,, Bogner KH,, Sing A . 2007. Enterohemorrhagic Escherichia coli excretion by child and her cat. Emerg Infect Dis 13 : 348 349.[PubMed] [CrossRef]
172. Woods JB,, Schmitt CK,, Darnell SC,, Meysick KC,, O’Brien AD . 2002. Ferrets as a model system for renal disease secondary to intestinal infection with Escherichia coli O157:H7 and other Shiga toxin-producing E. coli . J Infect Dis 185 : 550 554.[PubMed] [CrossRef]
173. Zotta E,, Lago N,, Ochoa F,, Repetto HA,, Ibarra C . 2008. Development of an experimental hemolytic uremic syndrome in rats. Pediatr Nephrol 23 : 559 567.[PubMed] [CrossRef]
174. Garcia A,, Bosques CJ,, Wishnok JS,, Feng Y,, Karalius BJ,, Butterton JR,, Schauer DB,, Rogers AB,, Fox JG . 2006. Renal injury is a consistent finding in Dutch belted rabbits experimentally infected with enterohemorrhagic Escherichia coli . J Infect Dis 193 : 1125 1134.[PubMed] [CrossRef]
175. Sueyoshi M,, Nakazawa M . 1994. Experimental infection of young chicks with attaching and effacing Escherichia coli . Infect Immun 62 : 4066 4071.[PubMed]
176. Tzipori S,, Wachsmuth IK,, Chapman C,, Birden R,, Brittingham J,, Jackson C,, Hogg J . 1986. The pathogenesis of hemorrhagic colitis caused by Escherichia coli O157:H7 in gnotobiotic piglets. J Infect Dis 154 : 712 716.[PubMed] [CrossRef]
177. Taylor FB Jr,, Tesh VL,, DeBault L,, Li A,, Chang AC,, Kosanke SD,, Pysher TJ,, Siegler RL . 1999. Characterization of the baboon responses to Shiga-like toxin: descriptive study of a new primate model of toxic responses to Stx-1. Am J Pathol 154 : 1285 1299.[PubMed] [CrossRef]
178. Kang G,, Pulimood AB,, Koshi R,, Hull A,, Acheson D,, Rajan P,, Keusch GT,, Mathan VI,, Mathan MM . 2001. A monkey model for enterohemorrhagic Escherichia coli infection. J Infect Dis 184 : 206 210.[PubMed] [CrossRef]
179. Mohawk KL,, Melton-Celsa AR,, Zangari T,, Carroll EE,, O’Brien AD . 2010. Pathogenesis of Escherichia coli O157:H7 strain 86-24 following oral infection of BALB/c mice with an intact commensal flora. Microb Pathog 48 : 131 142.[PubMed] [CrossRef]
180. Mayer CL,, Leibowitz CS,, Kurosawa S,, Stearns-Kurosawa DJ . 2012. Shiga toxins and the pathophysiology of hemolytic uremic syndrome in humans and animals. Toxins (Basel) 4 : 1261 1287.[PubMed] [CrossRef]
181. Melton-Celsa AR,, O’Brien AD . 2003. Animal models for STEC-mediated disease. Methods Mol Med 73 : 291 305.[PubMed]
182. Beutin L,, Martin A . 2012. Outbreak of Shiga toxin-producing Escherichia coli (STEC) O104: H4 infection in Germany causes a paradigm shift with regard to human pathogenicity of STEC strains. J Food Prot 75 : 408 418.[PubMed] [CrossRef]
183. Karch H,, Tarr PI,, Bielaszewska M . 2005. Enterohaemorrhagic Escherichia coli in human medicine. Int J Med Microbiol 295 : 405 418.[PubMed] [CrossRef]
184. Snedeker KG,, Shaw DJ,, Locking ME,, Prescott RJ . 2009. Primary and secondary cases in Escherichia coli O157 outbreaks: a statistical analysis. BMC Infect Dis 9 : 144. [PubMed] [CrossRef]
185. Mead PS,, Griffin PM . 1998. Escherichia coli O157:H7. Lancet 352 : 1207 1212.[PubMed] [CrossRef]
186. Wilson JB,, Clarke RC,, Renwick SA,, Rahn K,, Johnson RP,, Karmali MA,, Lior H,, Alves D,, Gyles CL,, Sandhu KS,, McEwen SA,, Spika JS . 1996. Vero cytotoxigenic Escherichia coli infection in dairy farm families. J Infect Dis 174 : 1021 1027.[PubMed] [CrossRef]
187. Wilson JB,, Johnson RP,, Clarke RC,, Rahn K,, Renwick SA,, Alves D,, Karmali MA,, Michel P,, Orrbine E,, Spika JS . 1997. Canadian perspectives on verocytotoxin-producing Escherichia coli infection. J Food Prot 60 : 1451 1453.
188. Miliwebsky E,, Deza N,, Chinen I,, Martinez Espinosa E,, Gomez D,, Pedroni E,, Caprile L,, Bashckier A,, Manfredi E,, Leotta G . 2007. Prolonged fecal shedding of Shiga toxin-producing Escherichia coli among children attending day-care centers in Argentina. Rev Argent Microbiol 39 : 90 92.[PubMed]
189. Rangel JM,, Sparling PH,, Crowe C,, Griffin PM,, Swerdlow DL . 2005. Epidemiology of Escherichia coli O157:H7 outbreaks, United States, 198–2002. Emerg Infect Dis 11 : 603 609.[PubMed] [CrossRef]
190. Pennington H . 2010. Escherichia coli O157. Lancet 376 : 1428 1435.[PubMed] [CrossRef]
191. Mohammed Hamzah A,, Mohammed Hussein A,, Mahmoud Khalef J . 2013. Isolation of Escherichia coli 0157: H7 strain from fecal samples of zoo animal. Scientific World Journal 2013.
192. Featherstone CA,, Foster AP,, Chappell SA,, Carson T,, Pritchard GC . 2011. Verocytotoxigenic Escherichia coli O157 in camelids. Vet Rec 168 : 194 195.[PubMed] [CrossRef]
193. Dipineto L,, Gargiulo A,, Russo TP,, De Luca Bossa LM,, Borrelli L,, d’Ovidio D,, Sensale M,, Menna LF,, Fioretti A . 2010. Survey of Escherichia coli O157 in captive frogs. J Wildl Dis 46 : 944 946.[PubMed] [CrossRef]
194. Johnson M . 2005. Deer eating away at forests nationwide. The Associated Press, January 18, 2005.
195. United States Department of Agriculture . 2011. Feral swine: damage and disease threat. http://www.aphis.usda.gov/publications/wildlife_damage/content/printable_version/feral_swine.pdf.


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Animal hosts of Shiga toxin-producing