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Category: Clinical Microbiology
Clinical Studies of Escherichia coli O157:H7 Conjugate Vaccines in Adults and Young Children, Page 1 of 2
< Previous page | Next page > /docserver/preview/fulltext/10.1128/9781555818791/9781555818784_Chap24-1.gif /docserver/preview/fulltext/10.1128/9781555818791/9781555818784_Chap24-2.gifAbstract:
Shiga toxin (Stx)-producing Escherichia coli (STEC) is a food-borne pathogen that can lead to complications such as hemorrhagic colitis and hemolytic-uremic syndrome (HUS), serious sequelae. In the United States, the most common E. coli serotype causing outbreaks is O157:H7, although non-O157 serotypes also cause the same disease, but in much fewer cases. The highest incidence rate is among children of preschool age ( 1 , 2 ).
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Serum anti-Vi IgG response in healthy adults receiving one injection of OSP-rEPA (striped bars), DeALPS-rEPA1 (dotted bars), or DeALPS-rEPA2 (solid bars); n = 29 in each group.
Serum anti-Vi IgG response in children 2 to 5 years old receiving one injection (dotted bars) or a booster dose 6 weeks later (solid bars); n = 25 in each group. No statistical difference between the groups at all periods.
Reciprocal bactericidal activity of serum LPS antibodies elicited in 2- to 5-year-old children injected with E. coli O157-rEPA conjugates a
Neutralization titers of Stx1 in sera from mice injected with E. coli O157 OSP conjugated with Stx1B