Chapter 24 : Clinical Studies of O157:H7 Conjugate Vaccines in Adults and Young Children

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Shiga toxin (Stx)-producing (STEC) is a food-borne pathogen that can lead to complications such as hemorrhagic colitis and hemolytic-uremic syndrome (HUS), serious sequelae. In the United States, the most common serotype causing outbreaks is O157:H7, although non-O157 serotypes also cause the same disease, but in much fewer cases. The highest incidence rate is among children of preschool age ( ).

Citation: Szu S, Ahmed A. 2015. Clinical Studies of O157:H7 Conjugate Vaccines in Adults and Young Children, p 487-501. In Sperandio V, Hovde C (ed), Enterohemorrhagic and Other Shiga Toxin-Producing . ASM Press, Washington, DC. doi: 10.1128/microbiolspec.EHEC-0016-2013
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Figure 1

Serum anti-Vi IgG response in healthy adults receiving one injection of OSP-rEPA (striped bars), DeALPS-rEPA (dotted bars), or DeALPS-rEPA (solid bars); = 29 in each group.

Citation: Szu S, Ahmed A. 2015. Clinical Studies of O157:H7 Conjugate Vaccines in Adults and Young Children, p 487-501. In Sperandio V, Hovde C (ed), Enterohemorrhagic and Other Shiga Toxin-Producing . ASM Press, Washington, DC. doi: 10.1128/microbiolspec.EHEC-0016-2013
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Image of Figure 2
Figure 2

Serum anti-Vi IgG response in children 2 to 5 years old receiving one injection (dotted bars) or a booster dose 6 weeks later (solid bars); = 25 in each group. No statistical difference between the groups at all periods.

Citation: Szu S, Ahmed A. 2015. Clinical Studies of O157:H7 Conjugate Vaccines in Adults and Young Children, p 487-501. In Sperandio V, Hovde C (ed), Enterohemorrhagic and Other Shiga Toxin-Producing . ASM Press, Washington, DC. doi: 10.1128/microbiolspec.EHEC-0016-2013
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Table 1

Reciprocal bactericidal activity of serum LPS antibodies elicited in 2- to 5-year-old children injected with O157-rEPA conjugates

Citation: Szu S, Ahmed A. 2015. Clinical Studies of O157:H7 Conjugate Vaccines in Adults and Young Children, p 487-501. In Sperandio V, Hovde C (ed), Enterohemorrhagic and Other Shiga Toxin-Producing . ASM Press, Washington, DC. doi: 10.1128/microbiolspec.EHEC-0016-2013
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Neutralization titers of Stx1 in sera from mice injected with O157 OSP conjugated with Stx1B

Citation: Szu S, Ahmed A. 2015. Clinical Studies of O157:H7 Conjugate Vaccines in Adults and Young Children, p 487-501. In Sperandio V, Hovde C (ed), Enterohemorrhagic and Other Shiga Toxin-Producing . ASM Press, Washington, DC. doi: 10.1128/microbiolspec.EHEC-0016-2013

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