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Chapter 16.5 : Botulinum Toxin—

Editor: Amy L. Leber1
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Affiliations: 1: Editor in chief, Department of Laboratory Medicine, Nationwide Children’s Hospital, Columbus, Ohio
Content Type: Reference
Publication Year: 2016

Category: Clinical Microbiology

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Abstract:

organisms are straight to slightly curved, Gram-positive (in young cultures), motile, anaerobic rods, 0.5 to 2.0 μm in width and 1.6 to 22.0 μm in length, with oval, subterminal spores ( ). is a Select Agent Tier 1 organism. Sentinel clinical laboratories will not isolate nor identify or its toxins. In suspected cases of botulism, sentinel clinical laboratories will obtain appropriate specimens, ensure that they are packaged safely, and consult with the patient’s physician, their designated Laboratory Response Network (LRN) reference laboratory, and the CDC. Sentinel clinical laboratories are defined as those certified to perform high-complexity testing under the Clinical Laboratory Improvement Amendments of 1988 (CLIA’88) by the Centers for Medicare and Medicaid Services for the applicable microbiology specialty. Laboratory in-house testing includes Gram stains and at least one of the following: lower respiratory tract, wound, or blood cultures.

Citation: Leber A. 2016. Botulinum Toxin—, p 16.5.1-16.5.9. In Clinical Microbiology Procedures Handbook, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818814.ch16.5
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Figures

Botulinum Toxin—Clostridium botulinum
Citation: Leber A. 2016. Botulinum Toxin—, p 16.5.1-16.5.9. In Clinical Microbiology Procedures Handbook, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818814.ch16.5
/content/10.1128/9781555818814.chap16.5.fig16.5-1
Figure 16.5–1
management flow chart
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10.1128/9781555818814/fig16.5-1.gif
Image of Figure 16.5–1
Figure 16.5–1

management flow chart

Citation: Leber A. 2016. Botulinum Toxin—, p 16.5.1-16.5.9. In Clinical Microbiology Procedures Handbook, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818814.ch16.5
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References

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1. Stevens DL, Bryant AE, Berger A, von Eichel/Streiber C. 2011. Clostridium, p 834– 857. In Versalovic J, Carroll KC, Funke G, Jorgensen JH, Landry ML, Warnock DW (ed.), Manual of Clinical Microbiology, 10th ed. ASM Press, Washington, DC.
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Tables

Botulinum Toxin—Clostridium botulinum
Citation: Leber A. 2016. Botulinum Toxin—, p 16.5.1-16.5.9. In Clinical Microbiology Procedures Handbook, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818814.ch16.5
/content/10.1128/9781555818814.chap16.5.table16.5-1
Table 16.5–1
Collection and transport of clinical specimens for laboratory testing and confirmation
Generic image for table
Table 16.5–1

Collection and transport of clinical specimens for laboratory testing and confirmation

Citation: Leber A. 2016. Botulinum Toxin—, p 16.5.1-16.5.9. In Clinical Microbiology Procedures Handbook, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818814.ch16.5

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