Chapter 5.8 : Screening Tests for Detection of High-Level Mupirocin Resistance in

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Screening Tests for Detection of High-Level Mupirocin Resistance in , Page 1 of 2

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High-level mupirocin resistance (HLMR) in is defined by a mupirocin MIC ≥512 μg/ml and is associated with the presence of plasmid-encoded genes in these isolates ( ). Neither the US Food and Drug Administration nor the CLSI have established interpretive criteria for mupirocin when using standard disk diffusion or broth or agar dilution MIC methods. However, two screening methods for detection of HLMR are described herein. These include assessing growth at a high concentration of mupirocin (256 μg/ml) by broth microdilution (BMD) or by disk diffusion using a 200-μg mupirocin disk ( ). Details regarding recommended procedures for disk diffusion testing and BMD testing can be found in procedure 5.1 and/or CLSI M02-A12 ( ) and procedure 5.2 and/or CLSI M07-A10 ( ), respectively.

Citation: Leber A. 2016. Screening Tests for Detection of High-Level Mupirocin Resistance in , p 5.8.1-5.8.4. In Clinical Microbiology Procedures Handbook, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818814.ch5.8
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