Chapter 2.5.7 : Study Design

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When designing a study to develop/optimize a method, evaluate method performance, validate a method, or test a hypothesis, there are many factors to consider, for example, matrix/matrices (e.g., water, soil), spiking, organism strain, number of replicates, and QC analyses.

Citation: Chambers Y, Oshiro R. 2016. Study Design, p 2.5.7-1-2.5.7-2. In Yates M, Nakatsu C, Miller R, Pillai S (ed), Manual of Environmental Microbiology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555818821.ch2.5.7
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1. U.S. Environmental Protection Agency. 1988. Availability, Adequacy, and Comparability of Testing Procedures for the Analysis of Pollutants Established Under Section 304(h) of the Federal Water Pollution Control Act. EPA/600/9-87/030. Cincinnati, OH.
2. U.S. Environmental Protection Agency. 2010. EPA Microbiological Alternate Test Procedure (ATP) Protocol for Drinking Water, Ambient Water, Wastewater, and Sewage Sludge Monitoring Methods. EPA-821-B-10-001. Office of Water, Washington DC.
3. American Society for Testing and Materials. 1998. Annual Book of ASTM Standards, vol. 11.01. Philadelphia, PA.

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