Molecular Genetics of Mycobacteria, Second Edition

Editors: Graham F. Hatfull1, William R. Jacobs2
Affiliations: 1: Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260; 2: Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, NY 10461
Content Type: Monograph
Format: Hardcover
Publication Year: 2014

Category: Microbial Genetics and Molecular Biology

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Tuberculosis, caused by , causes one in four avoidable deaths in the developing world and kills more adults than malaria, AIDS, and all tropical diseases combined. TB is now considered a global health emergency; a distinction never accorded another disease. Although the field of mycobacterial genetics has expanded dramatically, with investigations into new areas of mycobacterial growth, replication, metabolism, physiology, drug susceptibility, and virulence, most of the problems in tuberculosis control that existed in 2000 are still with us today.

The good news is that the advances in mycobacterial genetics are beginning to be reflected in exciting recent developments. New diagnostic approaches can determine drug resistance within a few hours, promising new drugs are progressing through the pipeline and into the clinic, and a range of newly developed vaccines are being evaluated. It is an exciting time as the fruits of 30 years of intensive genetic investigation are finally beginning to emerge.

Written by leading experts in the field, :

  • Discusses key areas of current research in mycobacterial genetics.
  • Explains the genetics of the physiology, metabolism, and drug sensitivities of Mycobacterium tuberculosis.
  • Provides a resource to learn about genetic approaches for manipulating Mycobacterium tuberculosis.
  • Presents an invaluable handbook for anyone interested in mycobacterial genetics or wishing to enter the field of research into Mycobacterium tuberculosis or other mycobacterial species.

This book is an invaluable resource for anyone interested in the molecular genetics and molecular biology of mycobacteria.

is an extraordinary book. It includes chapters from virtually every major scientific contributor to the genetic understanding of mycobacteria. For anyone entering the field or seeking to learn about fundamental genetic and molecular aspects of mycobacteria, this book is a necessity.”

-Barry R. Bloom, Harvard University Distinguished Service Professor and Former Dean, Harvard School of Public Health

, is a professor of biological sciences, Eberly Family Professor of Biotechnology, and a Howard Hughes Medical Institute professor at the University of Pittsburgh. Dr. Hatfull studies the molecular genetics of the mycobacteria and their phages. He leads integrated research and education programs to discover and sequence new phages and uses phage genomic information to develop tools to manipulate and understand M. tuberculosis. Dr. Hatfull began work on the mycobacteriophages in 1988 and has collaborated with Dr. Jacobs since that time, leading to collaborative grant funding and many coauthored publications.

, is a professor of microbiology and immunology and a professor of genetics at the Albert Einstein College of Medicine and an investigator with the Howard Hughes Medical Institute. He has studied mycobacterial diseases, including leprosy and tuberculosis, for the last 34 years. Dr. Jacobs’ research interests have focused on understanding the mechanisms of drug-resistant tuberculosis, immune evasion of M. tuberculosis, development of recombinant BCG vaccine vectors, and development of reporter phages for rapidly assessing drug susceptibilities in M. tuberculosis isolates. He is working to understand the persistence phenotype of M. tuberculosis in order to develop improved chemotherapies and vaccines. Dr. Jacobs and Dr. Hatfull have collaborated on the genetic analysis of phages, which has led to integration-proficient vectors and improved phage vectors as tools for clarifying the molecular biology of M. tuberculosis.

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