Plasmids: Biology and Impact in Biotechnology and Discovery

Editors: Marcelo E. Tolmasky1, Juan C. Alonso2
Affiliations: 1: Center for Applied Biotechnology Studies, Department of Biological Science, College of Natural Sciences and Mathematics, California State University, Fullerton; 2: Centro Nacional de Biotecnología, CSIC, Departamento de Biotecnología Microbiana, Madrid, Spain
Content Type: Monograph
Format: Electronic
Publication Year: 2015

Category: Clinical Microbiology

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Explore the remarkable discoveries in the rapidly expanding field of plasmid biology

Plasmids are integral to biological research as models for innumerable mechanisms of living cells, as tools for creating the most diverse therapies, and as crucial helpers for understanding the dissemination of microbial populations. Their role in virulence and antibiotic resistance, together with the generalization of “omics” disciplines, has recently ignited a new wave of interest in plasmids.

This comprehensive book contains a series of expertly written chapters focused on plasmid biology, mechanistic details of plasmid function, and the increased utilization of plasmids in biotechnology and pharmacology that has occurred in the past decade.

serves as an invaluable reference for researchers in the wide range of fields and disciplines that utilize plasmids and can also be used as a textbook for upper-level undergraduate and graduate courses in biotechnology and molecular biology.

"The study and utilization of plasmids is experiencing renewed interest. This book is a comprehensive and illustrative source where readers can find the latest advances in all aspects of plasmids, from the basic understanding of their biology to their utilization as tools in the modern laboratory."

—Luis A. Actis, Professor and Chair, Department of Microbiology, Miami University

" compiles information on the recent progress achieved in the field of Plasmid Biology. It constitutes a wealth of inextinguishable knowledge, and is an important reference for all scientists working in the expanding and interconnected world of modern biology."

—Prof. Manuel Espinosa, Professor 'ad honorem' at the Centro de Investigaciones Biológicas from the Consejo Superior de Investigaciones Científicas

is a Professor at the Department of Biology, California State University, Fullerton, and the Director of the Center for Applied Biotechnology Studies. He did his PhD at the Fundación Instituto Leloir under the mentorship of Luis F. Leloir and his postdoctoral training in Jorge H. Crosa’s laboratory at the Oregon Health & Sciences University, where he studied virulence and antibiotic resistance plasmids in Gram-negatives. His current research focuses on several basic and applied aspects of plasmid-mediated multidrug resistance and virulence. He was a coeditor of the book Enzyme-Mediated Resistance to Antibiotics: Mechanisms, Dissemination, and Prospects for Inhibition (ASM Press).

is a Research Professor at the Centro Nacional de Biotecnología (CSIC), Madrid, Spain. He did his PhDs at the School of Veterinary Science and Exact and Natural Sciences under the mentorship of Eduardo Zaccardi and Oscar Grau, respectively. He completed his postdoctoral training studying plasmid and chromosomal horizontal gene transfer in Bacillus subtilis in Thomas Trautner’s lab at the Max-Planck-Institute for Molecular Genetics, Berlin, Germany. Current research in his laboratory focuses on genomic stability in Firmicutes. Through genetic, cytological, biochemical, and biophysics approaches, the long-term goal is to define the molecular steps in the dynamic process of homologous recombination and DNA segregation.

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