Chapter 36 : Treatment of Parasitic Infections

Abstract:

Chemotherapy plays a very important role not only in reducing patient morbidity and mortality but also in reducing transmission of the parasitic infection. Many of the drugs used to treat parasitic infections have serious side effects; therefore, before initiation of therapy, it is important to consider the following factors: health of the patient, parasite drug resistance, accuracy of the original dose, potential drug toxicity, and the need for follow-up examinations to monitor therapy. The mechanisms of action of most antiparasitic drugs are not well known, including those involving potential drug toxicity to the patient. Because of the limited resources of developing nations, where a majority of parasitic infections occur, there is little commercial incentive for developing effective therapeutics or vaccines. For some drugs, such as triclabendazole, used extensively in veterinary practices, less is known about adverse side effects or toxicity to humans. Specific information can be obtained from the Centers for Disease Control and Prevention, CDC Drug Service, Atlanta, GA (day, 404-639-3670; evenings, weekends, and holidays, 404-639-2888). One can also obtain drugs from CDC that are not commercially available in the United States.