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Category: Clinical Microbiology
Surgical Pathologic Diagnosis, Page 1 of 2
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Surgical pathology results can play a crucial role in the management of immunocompromised patients. A number of factors contribute to the complexity of histologic diagnosis in these patients. The most obvious difference is that the inflammatory response to pathogens differs from that of immunocompetent hosts. Pathologists must remember to perform special stains for microorganisms, even if there is little or no inflammation in a biopsy specimen. Noticing the lack of inflammatory cells, such as the lack of plasma cells in patients with common-variable immunodeficiency, in tissues where they are normally present can lead to a diagnosis of immunodeficiency.
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Full text loading...
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Duodenal biopsy from a patient with CVID showing blunt villi and increased intraepithelial lymphocytes.
Duodenal biopsy from a patient with CVID showing blunt villi and increased intraepithelial lymphocytes.
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Higher-power view of duodenal biopsy shown in Fig. 1 . Note the paucity of plasma cells.
Higher-power view of duodenal biopsy shown in Fig. 1 . Note the paucity of plasma cells.
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Kaposi sarcoma of the skin with ectatic blood-filled spaces.
Kaposi sarcoma of the skin with ectatic blood-filled spaces.
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Same biopsy as Fig. 3 stained with immunohistochemical stain for CD34, which outlines the vascular spaces.
Same biopsy as Fig. 3 stained with immunohistochemical stain for CD34, which outlines the vascular spaces.
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Same biopsy as Fig. 3 stained with immunohistochemical stain for HHV8, which highlights the nuclei of virally infected cells.
Same biopsy as Fig. 3 stained with immunohistochemical stain for HHV8, which highlights the nuclei of virally infected cells.
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015In situ hybridization for EBER showing positive nuclei in a lymph node.
In situ hybridization for EBER showing positive nuclei in a lymph node.
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Anal condyloma due to HPV.
Anal condyloma due to HPV.
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Viral inclusions of HPV in a plantar wart.
Viral inclusions of HPV in a plantar wart.
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Lymphocytic infiltrate in brain due to PML.
Lymphocytic infiltrate in brain due to PML.
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Renal tubule with intranuclear inclusions of polyoma virus.
Renal tubule with intranuclear inclusions of polyoma virus.
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Intranuclear and intracytoplasmic inclusions of CMV in gastric epithelial cell of a patient with AIDS.
Intranuclear and intracytoplasmic inclusions of CMV in gastric epithelial cell of a patient with AIDS.
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Positive nuclear staining with immunohistochemical stain for CMV from a skin biopsy from a transplant patient.
Positive nuclear staining with immunohistochemical stain for CMV from a skin biopsy from a transplant patient.
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Intranuclear inclusions of HSV within syncytia.
Intranuclear inclusions of HSV within syncytia.
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Intranuclear inclusions of varicella-zoster virus in skin in a patient with chicken pox.
Intranuclear inclusions of varicella-zoster virus in skin in a patient with chicken pox.
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Intranuclear inclusions of adenovirus infection in liver.
Intranuclear inclusions of adenovirus infection in liver.
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Intracellular Gram-positive bacteria of Rhodococcus equi in pulmonary malakoplakia (Brown-Hopps stain).
Intracellular Gram-positive bacteria of Rhodococcus equi in pulmonary malakoplakia (Brown-Hopps stain).
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Michaelis-Gutmann bodies in pulmonary malakoplakia.
Michaelis-Gutmann bodies in pulmonary malakoplakia.
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Fascicles of spindle cells in mycobacterial spindle-cell pseudotumor.
Fascicles of spindle cells in mycobacterial spindle-cell pseudotumor.
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Same tissue as in Fig. 17 demonstrating numerous acid-fast bacilli (Ziehl-Neelsen stain).
Same tissue as in Fig. 17 demonstrating numerous acid-fast bacilli (Ziehl-Neelsen stain).
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Pleomorphic rods of B. henselae (Warthin-Starry stain).
Pleomorphic rods of B. henselae (Warthin-Starry stain).
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Myriad acid-fast bacilli of M. tuberculosis in an anergic patient.
Myriad acid-fast bacilli of M. tuberculosis in an anergic patient.
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Hyphae of Rhizopus spp. invading an artery.
Hyphae of Rhizopus spp. invading an artery.
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Lung cavities due to PCP.
Lung cavities due to PCP.
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015P. jirovecii cysts. Note the large darkly stained capsular dot (GMS stain).
P. jirovecii cysts. Note the large darkly stained capsular dot (GMS stain).
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015H. capsulatum. Note the presence of narrow-neck budding (GMS stain).
H. capsulatum. Note the presence of narrow-neck budding (GMS stain).
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Granulomatous response to P. jirovecii.
Granulomatous response to P. jirovecii.
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Cryptosporidium spp. within intestinal-epithelial cells, but appearing to be on the surface.
Cryptosporidium spp. within intestinal-epithelial cells, but appearing to be on the surface.
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015I. belli organisms within intestinal-epithelial cells.
I. belli organisms within intestinal-epithelial cells.
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Free tachyzoites of T. gondii in brain.
Free tachyzoites of T. gondii in brain.
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Bradyzoites of T. gondii in a cyst in brain.
Bradyzoites of T. gondii in a cyst in brain.
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015G. intestinalis trophozoites in a duodenal biopsy.
G. intestinalis trophozoites in a duodenal biopsy.
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Gram-positive Enterocytozoon cuniculi spores within epithelial cells (Brown-Brenn stain).
Gram-positive Enterocytozoon cuniculi spores within epithelial cells (Brown-Brenn stain).
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Acid-fast E. cuniculi spores within epithelial cells (Ziehl-Neelsen stain).
Acid-fast E. cuniculi spores within epithelial cells (Ziehl-Neelsen stain).
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Pleistophora spp. spores depicting pink-staining polar granule (PAS stain).
Pleistophora spp. spores depicting pink-staining polar granule (PAS stain).
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Birefringent Pleistophora spp. spores.
Birefringent Pleistophora spp. spores.
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015E. bieneusi spores within duodenal-epithelial cells (Brown-Brenn stain).
E. bieneusi spores within duodenal-epithelial cells (Brown-Brenn stain).
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Normal eosinophilic Paneth cells at bases of intestinal crypts.
Normal eosinophilic Paneth cells at bases of intestinal crypts.
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Invasive filariform S. stercoralis larvae invoking an inflammatory reaction.
Invasive filariform S. stercoralis larvae invoking an inflammatory reaction.
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015Cross-section through one coiled S. stercoralis larva showing paired lateral alae.
Cross-section through one coiled S. stercoralis larva showing paired lateral alae.
Diagnostic Microbiology of the Immunocompromised Host, Second Edition
. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0023-2015