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Chapter 3 : Chronic Hepatitis B, C, and D

Authors: Bryan R. Cobb1, Alexandra Valsamakis2
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Affiliations: 1: Roche Diagnostics Corporation, Indianapolis, IN 46250; 2: Johns Hopkins Hospital, Baltimore, MD 21287
Content Type: Monograph
Publication Year: 2016

Category: Clinical Microbiology

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Abstract:

Viral hepatitis contributes significantly to the morbidity and mortality of at-risk individuals, particularly in chronic, untreated infections. Clinical symptoms vary from none (asymptomatic carriers) to fulminant liver failure. Hepatitis viruses A, B, C, D, and E are responsible for the majority of liver disease, with hepatitis A and E viruses being the least common of the culprits.

Citation: Cobb B, Valsamakis A. 2016. Chronic Hepatitis B, C, and D, p 69-95. In Hayden R, Wolk D, Carroll K, Tang Y (ed),

Diagnostic Microbiology of the Immunocompromised Host, Second Edition

. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0025-2015
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Chronic Hepatitis B, C, and D
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Citation: Cobb B, Valsamakis A. 2016. Chronic Hepatitis B, C, and D, p 69-95. In Hayden R, Wolk D, Carroll K, Tang Y (ed),

Diagnostic Microbiology of the Immunocompromised Host, Second Edition

. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0025-2015
/content/10.1128/9781555819040.chap3.fig3-1
Figure 1

Key HBV virion components.

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Figure 1

Key HBV virion components.

Citation: Cobb B, Valsamakis A. 2016. Chronic Hepatitis B, C, and D, p 69-95. In Hayden R, Wolk D, Carroll K, Tang Y (ed),

Diagnostic Microbiology of the Immunocompromised Host, Second Edition

. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0025-2015
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Figure 2

Phases and associated markers of CHB ( ).

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Image of Figure 2
Figure 2

Phases and associated markers of CHB ( ).

Citation: Cobb B, Valsamakis A. 2016. Chronic Hepatitis B, C, and D, p 69-95. In Hayden R, Wolk D, Carroll K, Tang Y (ed),

Diagnostic Microbiology of the Immunocompromised Host, Second Edition

. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0025-2015
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Figure 3

HBV exacerbation/reactivation risk associated with pharmacologic immunosuppression ( ).

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Image of Figure 3
Figure 3

HBV exacerbation/reactivation risk associated with pharmacologic immunosuppression ( ).

Citation: Cobb B, Valsamakis A. 2016. Chronic Hepatitis B, C, and D, p 69-95. In Hayden R, Wolk D, Carroll K, Tang Y (ed),

Diagnostic Microbiology of the Immunocompromised Host, Second Edition

. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0025-2015
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Figure 4

CDC testing algorithm for the identification of patients with CHC. Adapted from reference ( ).

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Image of Figure 4
Figure 4

CDC testing algorithm for the identification of patients with CHC. Adapted from reference ( ).

Citation: Cobb B, Valsamakis A. 2016. Chronic Hepatitis B, C, and D, p 69-95. In Hayden R, Wolk D, Carroll K, Tang Y (ed),

Diagnostic Microbiology of the Immunocompromised Host, Second Edition

. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0025-2015
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Figure 5

SVR rates with various regimens over the last 30 years ( ).

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Image of Figure 5
Figure 5

SVR rates with various regimens over the last 30 years ( ).

Citation: Cobb B, Valsamakis A. 2016. Chronic Hepatitis B, C, and D, p 69-95. In Hayden R, Wolk D, Carroll K, Tang Y (ed),

Diagnostic Microbiology of the Immunocompromised Host, Second Edition

. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0025-2015
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Figure 6

Regimens currently recommended for treatment of CHC ( ).

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Image of Figure 6
Figure 6

Regimens currently recommended for treatment of CHC ( ).

Citation: Cobb B, Valsamakis A. 2016. Chronic Hepatitis B, C, and D, p 69-95. In Hayden R, Wolk D, Carroll K, Tang Y (ed),

Diagnostic Microbiology of the Immunocompromised Host, Second Edition

. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0025-2015
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Figure 7

Current recommendations for viral load monitoring during treatment for CHC ( ).

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10.1128/9781555819040/fig3-7.gif
Image of Figure 7
Figure 7

Current recommendations for viral load monitoring during treatment for CHC ( ).

Citation: Cobb B, Valsamakis A. 2016. Chronic Hepatitis B, C, and D, p 69-95. In Hayden R, Wolk D, Carroll K, Tang Y (ed),

Diagnostic Microbiology of the Immunocompromised Host, Second Edition

. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.DMIH2-0025-2015
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