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Category: Clinical Microbiology
Molecular Detection and Characterization of Hepatitis C Virus, Page 1 of 2
< Previous page | Next page > /docserver/preview/fulltext/10.1128/9781555819071/9781555819088.ch31-1.gif /docserver/preview/fulltext/10.1128/9781555819071/9781555819088.ch31-2.gifAbstract:
Hepatitis C virus (HCV) and molecular methods are inextricably linked, in history and in clinical practice. This virus was the first to be identified with molecular methods (1) and nucleic acid tests have become fundamentally important in the diagnosis of infection and therapeutic management.
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HCV genome and protein coding scheme. UTR, untranslated region; NS, nonstructural gene; nuc, nucleotide; pos, position; aa, amino acid; gp, glycoprotein. Numbering according to references 83 and 84 .
HCV genome and protein coding scheme. UTR, untranslated region; NS, nonstructural gene; nuc, nucleotide; pos, position; aa, amino acid; gp, glycoprotein. Numbering according to references 83 and 84 .
Clinical features of acute hepatitis C following exposure to low viral inoculum such as occupational needlestick exposure or community-based exposure ( 35 , 85 , 86 ). Characteristics following higher dose exposure (transfusion with contaminated blood products) may be different. Intermittent viremia phase estimated from needlestick exposure ( 86 ). Kinetics of other characteristics derived from seroconversion panels ( 35 ). ALT, alanine amino transferase. Dashed lines indicate potential viremia patterns as defined by HCV RNA levels in peripheral blood. Adapted from reference 35 .
Clinical features of acute hepatitis C following exposure to low viral inoculum such as occupational needlestick exposure or community-based exposure ( 35 , 85 , 86 ). Characteristics following higher dose exposure (transfusion with contaminated blood products) may be different. Intermittent viremia phase estimated from needlestick exposure ( 86 ). Kinetics of other characteristics derived from seroconversion panels ( 35 ). ALT, alanine amino transferase. Dashed lines indicate potential viremia patterns as defined by HCV RNA levels in peripheral blood. Adapted from reference 35 .
Liver disease progression in chronic hepatitis C. Factors listed in notched arrow accelerate histologic progression of disease.
Liver disease progression in chronic hepatitis C. Factors listed in notched arrow accelerate histologic progression of disease.
Recommended testing algorithm for detection of HCV infection. Derived from reference 87 .
Recommended testing algorithm for detection of HCV infection. Derived from reference 87 .
Combination DAA regimens for chronic hepatitis C treatment
Combination DAA regimens for chronic hepatitis C treatment
Treatment of special populations of patients: interferon alfa-based therapies versus combination DAAs
Treatment of special populations of patients: interferon alfa-based therapies versus combination DAAs
Utility of HCV RNA tests in different treatment regimens
Utility of HCV RNA tests in different treatment regimens
Recommendations for chronic hepatitis C screening ( 39 )
Recommendations for chronic hepatitis C screening ( 39 )
Viral load monitoring recommendations in combination DAA treatment a
Viral load monitoring recommendations in combination DAA treatment a
Commercial HCV RNA qualitative tests a
Commercial HCV RNA quantification tests a
Commercial HCV RNA genotyping tests a
User-defined HCV RNA genotyping tests
User-defined HCV RNA genotyping tests
Blood screening NATs for HCV
Blood screening NATs for HCV