
Full text loading...
Category: Clinical Microbiology
Molecular Detection of Human Papillomaviruses, Page 1 of 2
< Previous page | Next page > /docserver/preview/fulltext/10.1128/9781555819071/9781555819088.ch33-1.gif /docserver/preview/fulltext/10.1128/9781555819071/9781555819088.ch33-2.gifAbstract:
The importance of human papillomaviruses (HPVs) in biology and medicine was highlighted by the award of the 2008 Nobel Prize in Medicine to Harald zur Hausen in recognition of his discovery of the oncogenic role of HPV in cervical cancer (1). Numerous international epidemiologic studies confirmed this association, which ultimately led to the successful development of vaccines that prevent HPV infection and tests that provide another tool for cervical cancer control.
Full text loading...
Schematic diagram of genomic organization of the open reading frame of human papillomavirus 16. P97 refers to dominant promoter. All papillomaviruses are similar in their genetic organization and appearance by electron microscopy. URR, upstream regulatory region.
Schematic diagram of genomic organization of the open reading frame of human papillomavirus 16. P97 refers to dominant promoter. All papillomaviruses are similar in their genetic organization and appearance by electron microscopy. URR, upstream regulatory region.
Phylogenetic tree based on the L1 open reading frame sequences of 170 HPV types, single animal papillomaviruses, and newly identified HPVs using metagenomic sequencing. The maximum likelihood method was used for the analysis and the tree was constructed using the MEGA5.1 program. The numbers at the ends of each of the branches identify an HPV type; m-numbers refer to metagenomics. All other abbreviations refer to animal PV types. The outermost semicircular symbols identify PV genera (e.g., the genus Alphapapillomavirus). The number at the inner semicircular symbol refers to PV species. To give an example taken from the upper part of the figure, the HPV types 33, 58, 67, 52, 31, 16, and 35 together form the HPV species 9 in the genus Alphapapillomavirus. Reprinted from de Villiers ( 5 ) with permission of the publisher.
Phylogenetic tree based on the L1 open reading frame sequences of 170 HPV types, single animal papillomaviruses, and newly identified HPVs using metagenomic sequencing. The maximum likelihood method was used for the analysis and the tree was constructed using the MEGA5.1 program. The numbers at the ends of each of the branches identify an HPV type; m-numbers refer to metagenomics. All other abbreviations refer to animal PV types. The outermost semicircular symbols identify PV genera (e.g., the genus Alphapapillomavirus). The number at the inner semicircular symbol refers to PV species. To give an example taken from the upper part of the figure, the HPV types 33, 58, 67, 52, 31, 16, and 35 together form the HPV species 9 in the genus Alphapapillomavirus. Reprinted from de Villiers ( 5 ) with permission of the publisher.
Summary of clinical tests for high-risk human papillomavirus detection discussed in this chapter
Summary of clinical tests for high-risk human papillomavirus detection discussed in this chapter