Chapter 45 : Host Response in HIV Infection

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HIV is widely considered as capable of infecting all humans and of leading to relentless disease progression. However, there is considerable diversity in human susceptibility to HIV and in clinical responses. Understanding the basis of interindividual diversity to infection is important for the development of diagnostic tools and vaccine development. Today, numerous studies in genetics, genomics, and early applications of systems biology have delivered knowledge on immunity against HIV on the basis of differences in disease manifestations (Table 1). Research has also led to the identification of biomarkers, in particular in the form of pharmacogenetic applications. This chapter will discuss the knowledge acquired through new technologies and describe the genetic tests that are in use in clinics or that may progress to routine use.

Citation: McLaren P, Telenti A. 2016. Host Response in HIV Infection, p 655-662. In Persing D, Tenover F, Hayden R, Ieven M, Miller M, Nolte F, Tang Y, van Belkum A (ed), Molecular Microbiology. ASM Press, Washington, DC. doi: 10.1128/9781555819071.ch45
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Knowledge gained from genomic research in HIV infection

Citation: McLaren P, Telenti A. 2016. Host Response in HIV Infection, p 655-662. In Persing D, Tenover F, Hayden R, Ieven M, Miller M, Nolte F, Tang Y, van Belkum A (ed), Molecular Microbiology. ASM Press, Washington, DC. doi: 10.1128/9781555819071.ch45
Generic image for table

Pharmacogenetic markers of interest in clinical care of HIV-infected individuals

Citation: McLaren P, Telenti A. 2016. Host Response in HIV Infection, p 655-662. In Persing D, Tenover F, Hayden R, Ieven M, Miller M, Nolte F, Tang Y, van Belkum A (ed), Molecular Microbiology. ASM Press, Washington, DC. doi: 10.1128/9781555819071.ch45

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