Chapter 25 : Hepatitis C Virus

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Hepatitis C virus (HCV) is a single-stranded RNA virus that was not known as a causative agent of acute and chronic hepatitis until 1989. The development of blood transfusion technology in the mid-20th century led to its rapid spread into new populations with enormous disease burden due to cirrhosis and hepatocellular carcinoma (1, 2). Its discovery by reverse molecular genetics is one of the major achievements of modern medicine and a model for the discovery of many other pathogens during the past 25 years (3). Unlike hepatitis B virus (HBV) and human immunodeficiency virus (HIV), which establish permanent chronic infection, HCV is spontaneously cleared in some individuals and is also amenable to therapeutic cure. With advances in drug therapies, all HCV infections are potentially curable. The development of technologies for viral discovery and clinical detection and monitoring, as well as new classes of antiviral therapy, are important components of the HCV legacy.

Citation: Mallory M, Hillyard D. 2016. Hepatitis C Virus, p 351-361. In Loeffelholz M, Hodinka R, Young S, Pinsky B (ed), Clinical Virology Manual, Fifth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819156.ch25
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HCV Viral Genome Organization

Citation: Mallory M, Hillyard D. 2016. Hepatitis C Virus, p 351-361. In Loeffelholz M, Hodinka R, Young S, Pinsky B (ed), Clinical Virology Manual, Fifth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819156.ch25
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Commercial anti-HCV screening assays

Citation: Mallory M, Hillyard D. 2016. Hepatitis C Virus, p 351-361. In Loeffelholz M, Hodinka R, Young S, Pinsky B (ed), Clinical Virology Manual, Fifth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819156.ch25
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Commercial HCV RNA tests

Citation: Mallory M, Hillyard D. 2016. Hepatitis C Virus, p 351-361. In Loeffelholz M, Hodinka R, Young S, Pinsky B (ed), Clinical Virology Manual, Fifth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819156.ch25

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