Chapter 31 : Human Polyomaviruses

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Human Polyomaviruses, Page 1 of 2

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The expanding family infect a variety of different hosts (1). Generally, avian polyomaviruses are highly pathogenic and have a wide host range, while mammalian polyomaviruses have a limited host range and are asymptomatic in the immunocompetent host (2, 3). At present, 13 of these species are linked to human infection, JC polyomavirus (JCPyV) (4), BK polyomavirus (BKPyV) (5), WU polyomavirus (WUPyV) (6), KI polyomavirus (KIPyV) (7), Merkel cell polyomavirus (MCPyV) (8), human polyomavirus 6 (HPyV6) (9), human polyomavirus 7 (HPyV7) (9), Trichodysplasia spinulosa-associated polyomavirus (TSPyV) (10) and human polyomavirus 9 (HPyV9) (11), Malawi polyomavirus (MWPyV) (12), St. Louis polyomavirus (STLPyV) (13), human polyomavirus 12 (HPyV12) (14), and New Jersey polyomavirus (NJPyV-2013) (15). Zoonotic infections have not been reported, however they cannot be completely excluded.

Citation: Rockett R, Nissen M, Sloots T, Bialasiewicz S. 2016. Human Polyomaviruses, p 427-442. In Loeffelholz M, Hodinka R, Young S, Pinsky B (ed), Clinical Virology Manual, Fifth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819156.ch31
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Image of FIGURE 1

A radial phylogenetic tree generated using a Neighbour-Joining analyses of concatenated VP2, VP1, and LTAg gene sequences from a wide variety of mammalian, bird, and fish polyomavirus species. All known human polyomaviruses are shown in red, with recognized polyomavirus subclades highlighted.

Citation: Rockett R, Nissen M, Sloots T, Bialasiewicz S. 2016. Human Polyomaviruses, p 427-442. In Loeffelholz M, Hodinka R, Young S, Pinsky B (ed), Clinical Virology Manual, Fifth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819156.ch31
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Image of FIGURE 2

Urine cytology micrograph showing polyomavirus infected cells (Decoy cells). (Copyright 2010 Nephron. Permission is granted to copy, distribute, and/or modify this image under the terms of the GNU Free Documentation License Version 1.3.)

Citation: Rockett R, Nissen M, Sloots T, Bialasiewicz S. 2016. Human Polyomaviruses, p 427-442. In Loeffelholz M, Hodinka R, Young S, Pinsky B (ed), Clinical Virology Manual, Fifth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819156.ch31
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Image of FIGURE 3

Proposed schematic for the screening and management of BKPyV replication and polyomavirus-associated nephropathy in kidney transplant patients (adapted from ( )).

Citation: Rockett R, Nissen M, Sloots T, Bialasiewicz S. 2016. Human Polyomaviruses, p 427-442. In Loeffelholz M, Hodinka R, Young S, Pinsky B (ed), Clinical Virology Manual, Fifth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819156.ch31
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