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Chapter 32 : Secretion from Myeloid Cells: Secretory Lysosomes

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Secretion from Myeloid Cells: Secretory Lysosomes, Page 1 of 2

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Abstract:

Over the last 20 years, a great deal of progress has been made in understanding the mechanisms that control the biogenesis and secretion of the modified lysosomes found in immune cells. The picture that emerges is that of a series of very successful “variations on a theme,” with different combinations of related proteins interacting to provide different mechanisms for secretion in each specialized cell type. This allows cytotoxic T lymphocytes (CTLs) to provide a very focused secretion toward a single point, while mast cells and platelets give a generalized release all around the plasma membrane.

Citation: Griffiths G. 2017. Secretion from Myeloid Cells: Secretory Lysosomes, p 593-597. In Gordon S (ed), Myeloid Cells in Health and Disease. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.MCHD-0030-2016
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Figures

Image of Figure 1
Figure 1

Rab27a interacts with different effector proteins to provide different modes of secretion. (Left) In melanosomes, Rab27a interacts with the Slp melanophilin (Mlph), which in turn interacts with myosin (Myo) Va and captures melanosomes onto cortical actin at the plus ends of microtubules. (Right) In CTLs, Rab27a interacts with Munc13-4 on secretory lysosomes and also interacts with Slp1 to -3, which are localized to the plasma membrane.

Citation: Griffiths G. 2017. Secretion from Myeloid Cells: Secretory Lysosomes, p 593-597. In Gordon S (ed), Myeloid Cells in Health and Disease. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.MCHD-0030-2016
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Image of Figure 2
Figure 2

Secretory lysosomes are delivered to an area of plasma membrane depleted in cortical actin. CTLs expressing actin-green fluorescent protein (green), fixed and stained with CD63 (red), forming a synapse viewed from the side and en face. Reprinted from reference ( ), with permission.

Citation: Griffiths G. 2017. Secretion from Myeloid Cells: Secretory Lysosomes, p 593-597. In Gordon S (ed), Myeloid Cells in Health and Disease. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.MCHD-0030-2016
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Image of Figure 3
Figure 3

Naive CD8 T cells express only low levels of Rac1 and no secretory lysosomes, Upon activation, TCR signaling triggers secretory lysosome biogenesis and prearms the CTL to kill. TCR signaling also activates Hh signaling, increasing levels of Rac1, required for actin reorganization and microtubule organization and thereby secretory lysosome polarization and release.

Citation: Griffiths G. 2017. Secretion from Myeloid Cells: Secretory Lysosomes, p 593-597. In Gordon S (ed), Myeloid Cells in Health and Disease. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.MCHD-0030-2016
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References

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