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Category: Microbial Genetics and Molecular Biology
Macrophages in Endocrine Glands, with Emphasis on Pancreatic Islets, Page 1 of 2
< Previous page | Next page > /docserver/preview/fulltext/10.1128/9781555819194/9781555819187_Chap48-1.gif /docserver/preview/fulltext/10.1128/9781555819194/9781555819187_Chap48-2.gifAbstract:
That macrophages normally inhabit endocrine organs became evident from the early studies in mice made in the laboratories of Siamon Gordon and David Hume ( 1 ). They used the macrophage surface marker F4/80 to examine tissue sections by immunohistochemistry and found macrophages in all endocrine organs. In most organs, the macrophages were found associated with the vessels. To note are several important examples. In the adrenal gland, the zona glomerulosa contained abundant macrophages that “wrapped around capillaries or line vascular sinuses, but membrane processes extend into the surrounding tissue.” In the pituitary, they found them distributed differentially in the various areas. In the thyroid, many surrounded the follicles. In the testes, the macrophages were next to the Leydig cells and not inside the seminiferous tubules. In the ovaries, macrophages were abundant around follicles and usually surrounding the vessels.
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Pancreatic macrophages (MΦ). The pancreas contains three sets of macrophages. One set reside in the islets, labeled endocrine tissue, and have an M1-like transcriptional signature. Two sets are in the stroma in between the acinar gland, labeled as exocrine tissue. Both have an M2-like transcriptional signature. One set derives from blood monocytes; the second derives from yolk sac (YS) hematopoiesis. Reprinted from reference 10 , with permission.
Pancreatic macrophages (MΦ). The pancreas contains three sets of macrophages. One set reside in the islets, labeled endocrine tissue, and have an M1-like transcriptional signature. Two sets are in the stroma in between the acinar gland, labeled as exocrine tissue. Both have an M2-like transcriptional signature. One set derives from blood monocytes; the second derives from yolk sac (YS) hematopoiesis. Reprinted from reference 10 , with permission.
Testicular macrophages. The macrophages in the testes are found in two locations. One set are in the interstitium, forming a cluster with Leydig cells. The second set surround the seminiferous tubules—the peritubular macrophages. Reproduced from reference 27 , with permission.
Testicular macrophages. The macrophages in the testes are found in two locations. One set are in the interstitium, forming a cluster with Leydig cells. The second set surround the seminiferous tubules—the peritubular macrophages. Reproduced from reference 27 , with permission.
Features of pancreatic macrophages
Features of pancreatic macrophages