Appendix C : Appendix: Iatrogenic Transmission of Zoonotic Agents

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Iatrogenic transmission of pathogens is generally possible for agents that circulate in the blood or infect tissues to be transplanted. Severe complications may arise, particularly if the agent is able to subsequently proliferate in the recipient. Apart from using contaminated tools, for instance, needles and syringes, iatrogenic transmission occurs mainly in the course of transfusion of blood or blood products and in organ transplantation. Major problems arise by the fact that usually relatively large amounts of agents are transmitted and the recipient is, in general, a sick person, impaired by an eventually reduced resistance or immunocompetence. Transmissions of the following zoonotic agents by transfusion of blood and blood products have been reported:

  • Viruses: Colorado tick fever virus, dengue fever virus, West Nile fever virus, Ross River fever virus, herpes B virus, lymphocytic choriomeningitis virus, rabies virus, yellow fever 17D vaccine. HIVs originating from monkeys have been established as human infectious agents;
  • Bacteria: , spp. ;
  • Parasites: spp., spp., spp., .

Citation: Bauerfeind R, Graevenitz A, Kimmig P, Schiefer H, Schwarz T, Slenczka W, Zahner H. 2016. Appendix: Iatrogenic Transmission of Zoonotic Agents, p 499-502. In Zoonoses: Infectious Diseases Transmissible From Animals and Humans, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819262.App03
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