Chapter 1 : Evolution of Bacterial Pathogens Within the Human Host

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The success or failure of a pathogen is entirely dependent on its ability to survive, reproduce, and spread to a new host or environment. Host immune systems, predators, microbial competitors, parasites, and environmental resource limitations all exert selective pressures that shape the genomes of microbial populations ( ). Host fitness, meanwhile, is determined by the ability of the host to survive and reproduce; the host must therefore effectively curtail diseases that impair either of these abilities.

Citation: Bliven K, Maurelli A. 2016. Evolution of Bacterial Pathogens Within the Human Host, p 3-13. In Kudva I, Cornick N, Plummer P, Zhang Q, Nicholson T, Bannantine J, Bellaire B (ed),

Virulence Mechanisms of Bacterial Pathogens, Fifth Edition

. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.VMBF-0017-2015
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Examples of pathogenic mechanisms to evade or overcome selective pressures within the human host

Citation: Bliven K, Maurelli A. 2016. Evolution of Bacterial Pathogens Within the Human Host, p 3-13. In Kudva I, Cornick N, Plummer P, Zhang Q, Nicholson T, Bannantine J, Bellaire B (ed),

Virulence Mechanisms of Bacterial Pathogens, Fifth Edition

. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.VMBF-0017-2015

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