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Chapter 24 : Intracellular Growth of Bacterial Pathogens: The Role of Secreted Effector Proteins in the Control of Phagocytosed Microorganisms

Authors: Valérie Poirier1, Yossef Av-gay2
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Affiliations: 1: Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, BC V6H 3Z6 Canada; 2: Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, BC V6H 3Z6 Canada
Content Type: Monograph
Publication Year: 2016
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Abstract:

Of the 56 million deaths reported worldwide in 2012, approximately 15 million are directly related to infectious diseases ( ). The majority of annual deaths are related to bacterial infections such as tuberculosis, yellow and typhoid fever, cholera, shigellosis, pneumonia, etc. ( ). Morbidity and mortality rates are highest in developing countries, where large numbers of infants and children count among the victims ( ). In developed nations, infectious disease mortality falls most heavily on indigenous and disadvantaged minorities ( ). The control of bacterial infectious diseases worldwide is an important task. Although antibiotics revolutionized the treatment of bacterial infections, increased resistance and the emergence of multidrug-resistant strains increasingly reduce their efficacy. This trend promotes an urgent need for better understanding of bacterial pathogenicity and resistance mechanisms, which will assist novel therapeutic and vaccination strategies.

Citation: Poirier V, Av-gay Y. 2016. Intracellular Growth of Bacterial Pathogens: The Role of Secreted Effector Proteins in the Control of Phagocytosed Microorganisms, p 693-713. In Kudva I, Cornick N, Plummer P, Zhang Q, Nicholson T, Bannantine J, Bellaire B (ed),

Virulence Mechanisms of Bacterial Pathogens, Fifth Edition

. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.VMBF-0003-2014
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Intracellular Growth of Bacterial Pathogens: The Role of Secreted Effector Proteins in the Control of Phagocytosed Microorganisms
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Citation: Poirier V, Av-gay Y. 2016. Intracellular Growth of Bacterial Pathogens: The Role of Secreted Effector Proteins in the Control of Phagocytosed Microorganisms, p 693-713. In Kudva I, Cornick N, Plummer P, Zhang Q, Nicholson T, Bannantine J, Bellaire B (ed),

Virulence Mechanisms of Bacterial Pathogens, Fifth Edition

. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.VMBF-0003-2014
/content/10.1128/9781555819286.chap24.fig24-1
Figure 1

Stages of phagosome maturation. During phagocytosis, the phagosome undergoes a series of fusion and fission events with vesicles of the endocytic pathway, culminating in the formation of the phagolysosome. Maturation of the phagosome involves gradual decrease in pH and acquisition of antimicrobial properties, leading to the digestion of the invader and presentation of antigens on the surface of the phagocyte by MHC-II molecules.

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10.1128/9781555819286/fig24-1.gif
Image of Figure 1
Figure 1

Stages of phagosome maturation. During phagocytosis, the phagosome undergoes a series of fusion and fission events with vesicles of the endocytic pathway, culminating in the formation of the phagolysosome. Maturation of the phagosome involves gradual decrease in pH and acquisition of antimicrobial properties, leading to the digestion of the invader and presentation of antigens on the surface of the phagocyte by MHC-II molecules.

Citation: Poirier V, Av-gay Y. 2016. Intracellular Growth of Bacterial Pathogens: The Role of Secreted Effector Proteins in the Control of Phagocytosed Microorganisms, p 693-713. In Kudva I, Cornick N, Plummer P, Zhang Q, Nicholson T, Bannantine J, Bellaire B (ed),

Virulence Mechanisms of Bacterial Pathogens, Fifth Edition

. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.VMBF-0003-2014
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Figure 2

Microbial effectors interfering with intracellular trafficking and acidification events. Orange proteins represent virulence factors; pink, virulence factors; and blue, virulence factors.

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10.1128/9781555819286/fig24-2.gif
Image of Figure 2
Figure 2

Microbial effectors interfering with intracellular trafficking and acidification events. Orange proteins represent virulence factors; pink, virulence factors; and blue, virulence factors.

Citation: Poirier V, Av-gay Y. 2016. Intracellular Growth of Bacterial Pathogens: The Role of Secreted Effector Proteins in the Control of Phagocytosed Microorganisms, p 693-713. In Kudva I, Cornick N, Plummer P, Zhang Q, Nicholson T, Bannantine J, Bellaire B (ed),

Virulence Mechanisms of Bacterial Pathogens, Fifth Edition

. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.VMBF-0003-2014
Permissions and Reprints Request Permissions
Download as Powerpoint
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Figure 3

Cytoskeleton remodeling, vacuolar membrane lysis, and phagosomal membrane remodeling by microbial pathogens. Orange proteins represent virulence factors; red, virulence factors; blue, virulence factors; and green, virulence factors.

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10.1128/9781555819286/fig24-3.gif
Image of Figure 3
Figure 3

Cytoskeleton remodeling, vacuolar membrane lysis, and phagosomal membrane remodeling by microbial pathogens. Orange proteins represent virulence factors; red, virulence factors; blue, virulence factors; and green, virulence factors.

Citation: Poirier V, Av-gay Y. 2016. Intracellular Growth of Bacterial Pathogens: The Role of Secreted Effector Proteins in the Control of Phagocytosed Microorganisms, p 693-713. In Kudva I, Cornick N, Plummer P, Zhang Q, Nicholson T, Bannantine J, Bellaire B (ed),

Virulence Mechanisms of Bacterial Pathogens, Fifth Edition

. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.VMBF-0003-2014
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Tables

Intracellular Growth of Bacterial Pathogens: The Role of Secreted Effector Proteins in the Control of Phagocytosed Microorganisms
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Citation: Poirier V, Av-gay Y. 2016. Intracellular Growth of Bacterial Pathogens: The Role of Secreted Effector Proteins in the Control of Phagocytosed Microorganisms, p 693-713. In Kudva I, Cornick N, Plummer P, Zhang Q, Nicholson T, Bannantine J, Bellaire B (ed),

Virulence Mechanisms of Bacterial Pathogens, Fifth Edition

. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.VMBF-0003-2014
/content/10.1128/9781555819286.chap24.tab24-1
TABLE 1

Host physiological events and substrates targeted by effectors secreted by , , , , , and species

Generic image for table
TABLE 1

Host physiological events and substrates targeted by effectors secreted by , , , , , and species

Citation: Poirier V, Av-gay Y. 2016. Intracellular Growth of Bacterial Pathogens: The Role of Secreted Effector Proteins in the Control of Phagocytosed Microorganisms, p 693-713. In Kudva I, Cornick N, Plummer P, Zhang Q, Nicholson T, Bannantine J, Bellaire B (ed),

Virulence Mechanisms of Bacterial Pathogens, Fifth Edition

. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.VMBF-0003-2014

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