Chapter 12 : Antiherpesvirus Agents

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The first effective agents against herpesviruses were nucleoside analogs, such as idoxuridine, vidarabine, and trifluridine. Their use was eventually supplanted by the highly successful drug, acyclovir, which had significantly less toxicity. In early studies, intravenous acyclovir was shown to be superior to vidarabine for treating herpes simplex virus (HSV) encephalitis in healthy hosts and varicella zoster virus (VZV) infections in immunosuppressed subjects and to be equivalent to vidarabine in treating neonatal HSV infections.

Citation: Gordon C, Kubin C, Hammer S. 2017. Antiherpesvirus Agents, p 215-237. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch12
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Image of FIGURE 1

Chemical structures of antiherpesvirus agents. (Reprinted with permission from reference [ ]).

Citation: Gordon C, Kubin C, Hammer S. 2017. Antiherpesvirus Agents, p 215-237. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch12
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Image of FIGURE 2

Chemical structures of investigational antiherpesvirus agents. (Reprinted with permission from reference [ ]).

Citation: Gordon C, Kubin C, Hammer S. 2017. Antiherpesvirus Agents, p 215-237. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch12
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