Chapter 24 : Human Herpesvirus 6 and Human Herpesvirus 7

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Human Herpesvirus 6 and Human Herpesvirus 7, Page 1 of 2

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Human herpesvirus 6 (HHV-6) was first isolated from patients with lymphoproliferative disorders in 1986 and was initially named ‘‘human B-lymphotropic virus (HBLV)’’ (1). It was found to mainly infect and replicate in lymphocytes of T-cell lineage (2). Subsequently, several reports described the isolation of similar viruses mainly from patients with HIV/AIDS. The characterization of HHV-6 indicated that the virus was antigenically and genetically distinct from the other five known human herpesviruses (1, 3). HHV-6 isolates are classified into two closely related groups that have been named variants A (HHV-6A) and B (HHV-6B). Primary HHV-6B infection occurs during infancy. This virus was recognized as the causative agent of exanthem subitum (ES) in 1988 (4).

Citation: Yamanishi K, Mori Y. 2017. Human Herpesvirus 6 and Human Herpesvirus 7, p 511-522. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch24
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Image of FIGURE 1

Herpes virus particles seen outside of HHV-6 infected cells.

Citation: Yamanishi K, Mori Y. 2017. Human Herpesvirus 6 and Human Herpesvirus 7, p 511-522. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch24
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Image of FIGURE 2

Genome structure of HHV-6B, HST strain; DR; direct repeat. (This figure was shown in a figure in reference .)

Citation: Yamanishi K, Mori Y. 2017. Human Herpesvirus 6 and Human Herpesvirus 7, p 511-522. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch24
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Image of FIGURE 3

HHV-6A/B and cellular receptors. gH/gL/gQ1/gQ2 complex expresses in HHV-6A/B envelope. HHV-6A gH/gL/gQ1/gQ2 complex binds to human CD46, and that of HHV-6B binds to human CD134.

Citation: Yamanishi K, Mori Y. 2017. Human Herpesvirus 6 and Human Herpesvirus 7, p 511-522. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch24
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Image of FIGURE 4

Clinical feature (typical rash) of a patient with exanthem subitum.

Citation: Yamanishi K, Mori Y. 2017. Human Herpesvirus 6 and Human Herpesvirus 7, p 511-522. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch24
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Image of FIGURE 5

Fluorescent hybridization (FISH) on metaphase chromosomes from a patient shows integration of HHV-6. The red and green signals indicate HHV-6 DNA and chromosome 6, respectively (the method is written in reference .)

Citation: Yamanishi K, Mori Y. 2017. Human Herpesvirus 6 and Human Herpesvirus 7, p 511-522. In Richman D, Whitley R, Hayden F (ed), Clinical Virology, Fourth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819439.ch24
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