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Category: Viruses and Viral Pathogenesis
Adenoviruses, Page 1 of 2
< Previous page | Next page > /docserver/preview/fulltext/10.1128/9781555819439/9781555819422.ch27-1.gif /docserver/preview/fulltext/10.1128/9781555819439/9781555819422.ch27-2.gifAbstract:
Adenoviruses were first isolated in 1953 from adenoids and tonsils surgically removed from children (1). Soon after the recovery of adenoviruses from patients with respiratory illness, their role as a major cause of febrile infections in young children and in army recruits was recognized. The illness was originally called acute respiratory disease (or ARD), but the signs and symptoms are similar to those of other viral respiratory syndromes, which should replace the old nonspecific expression.
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Schematic model illustrating the architecture of the adenovirus virion. The current view of the location and the copy number of polypeptides are indicated for the core and capsid proteins. Adapted and updated from ( 263 ).
Schematic model illustrating the architecture of the adenovirus virion. The current view of the location and the copy number of polypeptides are indicated for the core and capsid proteins. Adapted and updated from ( 263 ).
Adenovirus transcription map here exemplified with human adenovirus type 2. Note that the alternatively spliced structure of individual mRNAs expressed from the different early and late units are not shown ( 42 ). White arrows indicate early transcription units, thin arrows intermediate transcription units and black arrows late transcription units.
Adenovirus transcription map here exemplified with human adenovirus type 2. Note that the alternatively spliced structure of individual mRNAs expressed from the different early and late units are not shown ( 42 ). White arrows indicate early transcription units, thin arrows intermediate transcription units and black arrows late transcription units.
Diagram of adenovirus replication cycle. The approximate time scale for the different steps in the adenovirus life cycle is indicated at the bottom of the figure.
Diagram of adenovirus replication cycle. The approximate time scale for the different steps in the adenovirus life cycle is indicated at the bottom of the figure.
The seasonal distribution of adenovirus types circulating in Finland over a period of 4 years. The genotypings performed at the Department of Virology, University of Turku, represent 10 to 23% of adenovirus infections diagnosed in Finland each year.
Courtesy of Dr. Minna Ylihärsilä.
The seasonal distribution of adenovirus types circulating in Finland over a period of 4 years. The genotypings performed at the Department of Virology, University of Turku, represent 10 to 23% of adenovirus infections diagnosed in Finland each year.
Courtesy of Dr. Minna Ylihärsilä.
Pulmonary histopathology from a patient with a fatal case of adenoviral pneumonia. Characteristic epithelial smudge cells (arrow) show markedly enlarged nuclei containing inclusion bodies surrounded by thin rims of cytoplasm. Inclusion bodies are basophilic or amphophilic when stained with hemotoxylin and eosin. Unlike with herpesvirus infections, no syncytia or multinucleated giant cells are present.
Pulmonary histopathology from a patient with a fatal case of adenoviral pneumonia. Characteristic epithelial smudge cells (arrow) show markedly enlarged nuclei containing inclusion bodies surrounded by thin rims of cytoplasm. Inclusion bodies are basophilic or amphophilic when stained with hemotoxylin and eosin. Unlike with herpesvirus infections, no syncytia or multinucleated giant cells are present.
Use of adenovirus vaccines and febrile respiratory illness and adenovirus infection rates among United States Army trainees from 1998 to 2013. Reprinted from reference ( 8 ) with permission.
Use of adenovirus vaccines and febrile respiratory illness and adenovirus infection rates among United States Army trainees from 1998 to 2013. Reprinted from reference ( 8 ) with permission.