Chapter 8 : Chikungunya Virus: Current Perspectives on a Reemerging Virus

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Chikungunya virus (CHIKV) is believed to have originated in Africa and currently exists as three independent virus genotypes: West African, East/Central/South African (ECSA), and Asian. The first described incidence of human disease that was clearly attributable to CHIKV occurred on the Makonde Plateau of Tanzania (formerly Tanganyika) from October of 1952 until April of 1953 ( ). The virus responsible for this first outbreak was isolated from the serum of a febrile patient and belonged to what was ultimately designated the ECSA genotype. While this is the first documented incidence of CHIKV, phylogenetic and retrospective analyses of clinical data suggest that the virus may have been present and causing disease much earlier. Many researchers believe that Chikungunya fever (CHIK) may have been incorrectly identified as dengue fever, due to some overlapping symptomatology, in multiple areas throughout Southeast Asia as early as the start of the 18th century ( ).

Citation: Morrison C, Plante K, Heise M. 2016. Chikungunya Virus: Current Perspectives on a Reemerging Virus, p 143-161. In Scheld W, Hughes J, Whitley R (ed), Emerging infections 10. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.EI10-0017-2016
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CHIKV vaccine strategies

Citation: Morrison C, Plante K, Heise M. 2016. Chikungunya Virus: Current Perspectives on a Reemerging Virus, p 143-161. In Scheld W, Hughes J, Whitley R (ed), Emerging infections 10. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.EI10-0017-2016
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CHIKV antivirals

Citation: Morrison C, Plante K, Heise M. 2016. Chikungunya Virus: Current Perspectives on a Reemerging Virus, p 143-161. In Scheld W, Hughes J, Whitley R (ed), Emerging infections 10. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.EI10-0017-2016

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