1887

Chapter 33 : Esther Miriam Zimmer Lederberg: Pioneer in Microbial Genetics

MyBook is a cheap paperback edition of the original book and will be sold at uniform, low price.

Preview this chapter:
Zoom in
Zoomout

Esther Miriam Zimmer Lederberg: Pioneer in Microbial Genetics, Page 1 of 2

| /docserver/preview/fulltext/10.1128/9781555819545/9781555819538_Chap33-1.gif /docserver/preview/fulltext/10.1128/9781555819545/9781555819538_Chap33-2.gif

Abstract:

Esther Miriam Zimmer Lederberg (1922–2006) was an American microbiologist who did pioneering work with all of the ways bacteria transfer genetic information. She discovered bacteriophage λ in and with Joshua Lederberg first observed transduction. She characterized mutants to expand Beadle and Tatum’s “one gene, one protein” research, participated in early experiments in conjugation in the Lederberg lab at University of Wisconsin, and later worked on transformation of with plasmid DNA at Stanford University. The 1958 Nobel Prize was awarded to Joshua Lederberg, George Wells Beadle, and Edward Lawrie Tatum, and the Lederbergs subsequently moved to Stanford, where Joshua became chair of the Department of Genetics and Esther an untenured researcher in the Department of Medical Microbiology. They divorced in 1966. Esther stayed at Stanford but was never tenured; she became director of the Plasmid Reference Center (PRC) in 1976, organizing registration of the world’s plasmids, transposons, and insertion sequences. Officially retiring from Stanford in 1985, she continued at the PRC through 1986. Esther enjoyed performing early music and was a founder of the Mid Peninsular Recorder Orchestra. In 1989, she met Matthew Simon, an engineer newly arrived at Stanford; drawn together by shared interests in early music, botany, and literature, they married in 1993 and were together for the rest of her life. Esther will be remembered as a creative and meticulous experimentalist who was an active participant in creating the science of molecular biology, and as someone who continued to advance science through kindness and generosity in helping others.

Citation: Ferrell R. 2018. Esther Miriam Zimmer Lederberg: Pioneer in Microbial Genetics, p 305-315. In Whitaker R, Barton H (ed), Women in Microbiology. ASM Press, Washington, DC. doi: 10.1128/9781555819545.ch33
Highlighted Text: Show | Hide
Loading full text...

Full text loading...

Figures

Image of Figure 1
Figure 1

Esther Zimmer, age 15, shortly before her high school graduation in 1938. ©Esther M. Zimmer Lederberg memorial website (http://www.estherlederberg.com/home.html).

Citation: Ferrell R. 2018. Esther Miriam Zimmer Lederberg: Pioneer in Microbial Genetics, p 305-315. In Whitaker R, Barton H (ed), Women in Microbiology. ASM Press, Washington, DC. doi: 10.1128/9781555819545.ch33
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of Figure 2
Figure 2

Esther Lederberg, Director of the Plasmid Reference Center at Stanford University, at work in the laboratory in 1977. ©Esther M. Zimmer Lederberg memorial website (http://www.estherlederberg.com/home.html).

Citation: Ferrell R. 2018. Esther Miriam Zimmer Lederberg: Pioneer in Microbial Genetics, p 305-315. In Whitaker R, Barton H (ed), Women in Microbiology. ASM Press, Washington, DC. doi: 10.1128/9781555819545.ch33
Permissions and Reprints Request Permissions
Download as Powerpoint

References

/content/book/10.1128/9781555819545.chap33
1. Department of Commerce, Bureau of the Census . 1940. Sixteenth census of the United States: 1940. New York, New York City, Ward 2AD, Bronx, Block H sheet 2B. Viewed 28 September 2016, Denver Public Library, Denver, CO.
2. Lederberg J,, Lederberg EM . 1952. Replica plating and indirect selection of bacterial mutants. J Bacteriol 63 : 399 406.
3. Simon M (ed) . Esther M. Zimmer Lederberg Memorial Website. Online repository of materials from the Esther Lederberg archives at Stanford University Library. http://www.estherlederberg.com. Accessed 30 October 2016 through 27 August 2017.
4. Department of Commerce and Labor, Bureau of the Census . 1910. Thirteenth census of the United States: 1910. New York, New York City, Borough of Manhattan, Enumeration District 764, sheet 20B. Viewed 28 September 2016, Denver Public Library, Denver, CO.
5. Richmond C . 12 December 2006. Esther Lederberg. The Guardian, London, United Kingdom. https://www.theguardian.com/science/2006/dec/13/obituaries.guardianobituaries.
6. Scientific Legacies . Esther Lederberg’s diplomas and other awards. Scientific Legacies, Belmont, MA. http://www.scientificlegacies.org/esther-lederberg/diplomas.html. Accessed 23 August 2017.
7. Judson HF . 1979. The Eighth Day of Creation, p 368 369. Touchstone, Simon and Schuster, New York, NY.
8. Beadle GW,, Tatum EL . 1941. Genetic control of biochemical reactions in Neurospora. Proc Natl Acad Sci USA 27 : 499 506.
9. Zimmer EM . 1946. Mutant strains of Neurospora deficient in para-aminobenzoic acid. MA thesis, Stanford University, Stanford, CA.
10. Lederberg J . 1987. Genetic recombination in bacteria: a discovery account. Annu Rev Genet 21 : 23 46.
11. Tatum EL . 1945. X-ray induced mutant strains of Escherichia coli. Proc Natl Acad Sci USA 31 : 215 219.
12. Lederberg J,, Tatum EL . 1946. Gene recombination in Escherichia coli. Nature 158 : 558.
13. Giles NH Jr,, Lederberg EZ . 1948. Induced reversions of biochemical mutants in Neurospora crassa. Am J Bot 35 : 150 157.
14. Sarkar S . 2014. Lederberg on bacterial recombination, Haldane, and cold war genetics: an interview. Hist Philos Life Sci 36 : 280 288.
15. Pevzner L . 1996. Interview with Prof. Lederberg, winner of the 1958 Nobel Prize in physiology and medicine. http://www.almaz.com/nobel/medicine/lederberg-interview.html. Accessed 20 August 2017.
16. Lederberg EZ . 1950. Genetic control of mutability in the bacterium Escherichia coli. Ph.D. dissertation. University of Wisconsin, Madison, WI.
17. Lederberg EM . 1950. Lysogenicity in Escherichia coli strain K-12. Univ Wis Microb Genet Bull 1 : 5 9.
18. Lederberg EM . 1951. Lysogenicity in E. coli K-12. Genetics 36 : 560. (Abstract.)
19. Lederberg EM,, Lederberg J . 1953. Genetic studies of lysogeny in Escherichia coli. Genetics 38 : 51 64.
20. Watson JD,, Crick FH . 1953. Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. Nature 171 : 737 738.
21. Lederberg J,, Lederberg EM,, Zinder ND,, Lively ER . 1951. Recombination analysis of bacterial heredity. Cold Spring Harb Symp Quant Biol 16 : 413 443.
22. Russell PJ . 2002. iGenetics, p 289, 564–565. Benjamin Cummings, Pearson Education, San Francisco, CA.
23. Willey JM,, Sherwood LM,, Woolverton CJ . 2014. Prescott’s Microbiology, 9th ed. McGraw-Hill, New York, NY.
24. Lederberg EM . 1952. Allelic relationships and reverse mutation in Escherichia coli. Genetics 37 : 469 483.
25. Lederberg J,, Cavalli LL,, Lederberg EM . 1952. Sex compatibility in Escherichia coli. Genetics 37 : 720 730.
26. Cavalli LL,, Lederberg J,, Lederberg EM . 1953. An infective factor controlling sex compatibility in Bacterium coli. J Gen Microbiol 8 : 89 103.
27. Zinder ND,, Lederberg J . 1952. Genetic exchange in Salmonella. J Bacteriol 64 : 679 699.
28. Morse ML,, Lederberg EM,, Lederberg J . 1956. Transduction in Escherichia coli K-12. Genetics 41 : 142 156.
29. Morse ML,, Lederberg EM,, Lederberg J . 1956. Transductional heterogenotes in Escherichia coli. Genetics 41 : 758 779.
30. Lederberg J . 1958. Nobel Lecture: A view of genetics. http://www.nobelprize.org/nobel_prizes/medicine/laureates/1958/lederberg-lecture.html. Accessed 23 January 2018.
31. Herzenberg L,, Rindfleisch T,, Herzenberg L . 2008. Joshua Lederberg: the Stanford years (1958–1978). Annu Rev Genet 42 : 19 25.
32. Lederberg EM,, Cavalli-Sforza L,, Lederberg J . 1964. Interaction of streptomycin and a suppressor for galactose fermentation in E. coli K-12. Proc Natl Acad Sci USA 51 : 678 682.
33. Lederberg EM,, Cohen SN . 1974. Transformation of Salmonella typhimurium by plasmid deoxyribonucleic acid. J Bacteriol 119 : 1072 1074.
34. Tran C . 7 December 2006. Esther Lederberg dies; pioneering microbial geneticist was 83. The Scientist, Ontario, Canada.
35. Lederberg EM . 1987. Plasmid Reference Center Registry of transposon (Tn) and insertion sequence (IS) allocations through December 1986. Gene 51 : 115 118.
36. Piqueras M . 28 July 2014. Esther Lederberg, pioneer of bacterial genetics. Small Things Considered blog. http://schaechter.asmblog.org/schaechter/2014/07/esther-lederberg-pioneer-of-bacterial-genetics.html. Accessed 17 April 2017.
37. Oransky I . 2006. Esther Miriam Lederberg. Obituary. Lancet 368 : 2204.

This is a required field
Please enter a valid email address
Please check the format of the address you have entered.
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error