Chapter 43 : Fungal Recognition and Host Defense Mechanisms

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The immune system has over millennia evolved strategies to discriminate between what is “self” and what is foreign (nonself) as well as “normal self” and “injured or altered self,” with the ultimate purpose being to defend and repair self. First, to fully appreciate the framework that governs most of our current understanding of how the immune system operates, it is imperative to be cognizant of some of the immunological models that have laid the foundation on which we stand.

Citation: Dambuza I, Levitz S, Netea M, Brown G. 2017. Fungal Recognition and Host Defense Mechanisms, p 887-902. In Heitman J, Howlett B, Crous P, Stukenbrock E, James T, Gow N (ed), The Fungal Kingdom. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.FUNK-0050-2016
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More than half a century of immunogical theories.

Citation: Dambuza I, Levitz S, Netea M, Brown G. 2017. Fungal Recognition and Host Defense Mechanisms, p 887-902. In Heitman J, Howlett B, Crous P, Stukenbrock E, James T, Gow N (ed), The Fungal Kingdom. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.FUNK-0050-2016
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Figure 2

Signaling pathways involved in antifungal immunity.

Citation: Dambuza I, Levitz S, Netea M, Brown G. 2017. Fungal Recognition and Host Defense Mechanisms, p 887-902. In Heitman J, Howlett B, Crous P, Stukenbrock E, James T, Gow N (ed), The Fungal Kingdom. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.FUNK-0050-2016
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Figure 3

PRRs and the fungal components they recognize. (Adapted with modifications from reference ).

Citation: Dambuza I, Levitz S, Netea M, Brown G. 2017. Fungal Recognition and Host Defense Mechanisms, p 887-902. In Heitman J, Howlett B, Crous P, Stukenbrock E, James T, Gow N (ed), The Fungal Kingdom. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.FUNK-0050-2016
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Figure 4

Schematic representation of the sequential inflammatory immune reaction involved in antifungal immune responses.

Citation: Dambuza I, Levitz S, Netea M, Brown G. 2017. Fungal Recognition and Host Defense Mechanisms, p 887-902. In Heitman J, Howlett B, Crous P, Stukenbrock E, James T, Gow N (ed), The Fungal Kingdom. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.FUNK-0050-2016
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Table 1

Selected human genetic associations with fungal susceptibility discussed in this article

Citation: Dambuza I, Levitz S, Netea M, Brown G. 2017. Fungal Recognition and Host Defense Mechanisms, p 887-902. In Heitman J, Howlett B, Crous P, Stukenbrock E, James T, Gow N (ed), The Fungal Kingdom. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.FUNK-0050-2016

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