Chapter 1 : The Microbiota of Humans and Microbial Virulence Factors

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“The 1990s have been marked by a renewed recognition that our human species is still locked in a Darwinian struggle with our microbial and viral predators.” Although this unreferenced quotation was made by Nobel Laureate Joshua Lederberg, as he was discussing the acquired immunodeficiency syndrome (AIDS) and multidrug-resistant epidemics that emerged in the early 1990s, his comment could also apply to almost any infectious disease process that has occurred since the recognition of the germ theory of disease in the late 1880s. For as we journey through the 21st century, and despite the advances of modern medicine and the continual development of new vaccines and anti-infective therapeutic agents, the human species continues to battle microbial predators in this Darwinian struggle for survival.

Citation: Granato P. 2017. The Microbiota of Humans and Microbial Virulence Factors, p 3-17. In Wooley D, Byers K (ed), Biological Safety: Principles and Practices, Fifth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819637.ch1
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