1887

Chapter 16 : Design of Biomedical Laboratory and Specialized Biocontainment Facilities

MyBook is a cheap paperback edition of the original book and will be sold at uniform, low price.

Preview this chapter:
Zoom in
Zoomout

Design of Biomedical Laboratory and Specialized Biocontainment Facilities, Page 1 of 2

| /docserver/preview/fulltext/10.1128/9781555819637/9781555816209.ch16-1.gif /docserver/preview/fulltext/10.1128/9781555819637/9781555816209.ch16-2.gif

Abstract:

World circumstances have changed the small, simple biocontainment facilities of the past into larger, more complex facilities with difficult design decisions. There is not “one way” to design any laboratory; therefore this chapter provides both laboratory users and designers with relevant information to assist in making choices appropriate for the needs of specific projects. If the architect and engineers make decisions without local input and informed consent, it is unlikely that the completed laboratory will be satisfactory. The design of biomedical research laboratories, particularly biocontainment laboratories, is an exercise in making choices that are often between competing ideas and needs. However, if the potential users become an active, integral part of the process and an experienced design team is engaged, the facility will likely meet current needs and future requirements. Competent professional assistance is a necessity in this design process.

Citation: Crane J, Richmond J. 2017. Design of Biomedical Laboratory and Specialized Biocontainment Facilities, p 343-366. In Wooley D, Byers K (ed), Biological Safety: Principles and Practices, Fifth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819637.ch16
Highlighted Text: Show | Hide
Loading full text...

Full text loading...

Figures

Image of Figure 1
Figure 1

Percentage of building construction cost per new laboratory component.

Citation: Crane J, Richmond J. 2017. Design of Biomedical Laboratory and Specialized Biocontainment Facilities, p 343-366. In Wooley D, Byers K (ed), Biological Safety: Principles and Practices, Fifth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819637.ch16
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of Figure 2
Figure 2

A typical BSL2 laboratory.

Citation: Crane J, Richmond J. 2017. Design of Biomedical Laboratory and Specialized Biocontainment Facilities, p 343-366. In Wooley D, Byers K (ed), Biological Safety: Principles and Practices, Fifth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819637.ch16
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of Figure 3
Figure 3

Example layout of a small BSL3 suite.

Citation: Crane J, Richmond J. 2017. Design of Biomedical Laboratory and Specialized Biocontainment Facilities, p 343-366. In Wooley D, Byers K (ed), Biological Safety: Principles and Practices, Fifth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819637.ch16
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of Figure 4
Figure 4

Example layouts of typical BSL3 tissue culture rooms.

Citation: Crane J, Richmond J. 2017. Design of Biomedical Laboratory and Specialized Biocontainment Facilities, p 343-366. In Wooley D, Byers K (ed), Biological Safety: Principles and Practices, Fifth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819637.ch16
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of Figure 5
Figure 5

A typical BSL3 laboratory.

Citation: Crane J, Richmond J. 2017. Design of Biomedical Laboratory and Specialized Biocontainment Facilities, p 343-366. In Wooley D, Byers K (ed), Biological Safety: Principles and Practices, Fifth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819637.ch16
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of Figure 6
Figure 6

Example layout of an ABSL3 suite.

Citation: Crane J, Richmond J. 2017. Design of Biomedical Laboratory and Specialized Biocontainment Facilities, p 343-366. In Wooley D, Byers K (ed), Biological Safety: Principles and Practices, Fifth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819637.ch16
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of Figure 7
Figure 7

Example layout of a BSL3 autopsy suite.

Citation: Crane J, Richmond J. 2017. Design of Biomedical Laboratory and Specialized Biocontainment Facilities, p 343-366. In Wooley D, Byers K (ed), Biological Safety: Principles and Practices, Fifth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819637.ch16
Permissions and Reprints Request Permissions
Download as Powerpoint
Image of Figure 8
Figure 8

Example layout of a PBU.

Citation: Crane J, Richmond J. 2017. Design of Biomedical Laboratory and Specialized Biocontainment Facilities, p 343-366. In Wooley D, Byers K (ed), Biological Safety: Principles and Practices, Fifth Edition. ASM Press, Washington, DC. doi: 10.1128/9781555819637.ch16
Permissions and Reprints Request Permissions
Download as Powerpoint

References

/content/book/10.1128/9781555819637.ch16
1. Crane JT, Riley JF, . 1999. Design of BSL3 laboratories, p 111 119. In Richmond JY (ed.), Anthology of Biosafety, vol. 1. Perspectives on Laboratory Design. American Biological Safety Association, Mundelein, IL.
2. Crane JT, Bullock FC, Richmond JY, . 1999. Designing the BSL4 laboratory. In Richmond JY (ed.), Anthology of Biosafety, vol. 1. Perspectives on Laboratory Design . American Biological Safety Association, Mundelein, IL.
3. Kuehne RW . 1973. Biological containment facility for studying infectious disease. Appl Microbiol 26 : 239 243.[PubMed]
4. National Institutes of Health . 2013. NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules (NIH Guidelines), November 2013. http://osp.od.nih.gov/sites/default/files/NIH_Guidelines_0.pdf
5. Dolan DC, . 1981. Design for biomedical research facilities: architectural features of biomedical design, p 75 86. In Fox DG (ed), Design of Biomedical Research Facilities: Proceedings of a Cancer Research Safety Symposium, 1979. NIH publication 81-2305. Frederick Cancer Research Center, National Institutes of Health, Bethesda, MD.
6. West DL, Chatigny MA, . 1986. Design of microbiological and biomedical research facilities, p 124 137. In Miller BM (ed), Laboratory Safety: Principles and Practices. American Society for Microbiology, Washington, DC.
7. Chatigny MA, West DL . 1976. Laboratory ventilation rates: theoretical and practical considerations, p 71 100. In Proceedings of the Symposium on Laboratory Ventilation for Hazard Control. NIH Publication No. 82-1293. Frederick Cancer Research Center, Frederick, MD.
8. Centers for Disease Control and Prevention and National Institutes of Health . 1999. Biosafety in Microbiological and Biomedical Laboratories, 4th ed. U.S. Government Printing Office, Washington, DC.
9. U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institutes of Health . 2009. Biosafety in Microbiological and Biomedical Laboratories, 5th ed. HHS Publication no. (CDC) 21-112. http://www.cdc.gov/biosafety/publications/bmbl5/BMBL.pdf.
10. Richmond JY (ed). 2002. Anthology of Biosafety, vol. 5. BSL-4 Laboratories. American Biological Safety Association, Mundelein, IL.
11. Department of Labor . 1999. 29 CFR Part 1910.1030, Bloodborne Pathogens, Final Rule. Occupational Safety and Health Administration. U.S. Government Printing Office, Washington, DC.
12. Centers for Disease Control and Prevention . 1997. Goals for working safely with Mycobacterium tuberculosis in clinical, public health, and research laboratories. http://www.cdc.gov/od/ohs/tb/tbdoc2.htm.
13. American Institute of Architects, Committee on Architecture for Health . 2001. Guidelines for Construction and Equipment of Hospital and Medical Facilities. American Institute of Architects Press, Washington, DC.
14. Department of Labor . 1999. 29 CFR Part 1910.1450, Occupational Exposures to Hazardous Chemicals in Laboratories, Final Rule. Occupational Safety and Health Administration. U.S. Government Printing Office, Washington, DC.
15. Department of Labor . 1999. 29 CFR Part 1990, Identification, Classification, and Regulation of Potential Occupational Carcinogens. Occupational Safety and Health Administration. U.S. Government Printing Office, Washington, DC.
16. Crane JT, Riley JF, . 1997. Design issues in the comprehensive BSL2 and BSL3 laboratory, p 63 114. In Richmond JY (ed), Designing a Modern Microbiological/Biomedical Laboratory. American Public Health Association, Washington, DC.
17. Riley JF, Bullock FC, Crane JT, . 1999. Facility guidelines for BSL2 and BSL3 biological laboratories, p 99 109. In Richmond JY (ed.), Anthology of Biosafety, vol. 1. Perspectives on Laboratory Design. American Biological Safety Association, Mundelein, IL.
18. College of American Pathologists . 1985. Medical Laboratory Planning and Design. College of American Pathologists, Skokie, IL.
19. National Research Council . 1996. Guide for the Care and Use of Laboratory Animals. National Academies Press, Washington, DC.
20. Nolte KB, Taylor DG, Richmond JY, . 2001. Autopsy biosafety, p 1 50, In Richmond JY (ed), Anthology of Biosafety, IV. Issues in Public Health. American Biological Safety Association (ABSA), Chicago, IL.
21. Nolte KB, Taylor DG, Richmond JY . 2002. Biosafety considerations for autopsy. Am J Forensic Med Pathol 23 : 107 122.[PubMed]
22. ASHRAE Technical Committee . 1999. Industrial applications, laboratories, p 13.113.19. In ASHRAE Handbook, Applications. American Society of Heating, Refrigerating and Air-Conditioning Engineers, Inc., New York.
23. National Fire Protection Association . 2004. NFPA 45 Fire Protection for Laboratories Using Chemicals. National Fire Protection Agency, Quincy, MA.
24. Sessler SM, Hoover RM . 1983. Laboratory Fume Hood Noise, Heating Piping and Air Conditioning. Penton/PC Reinhold, Cleveland, OH.

This is a required field
Please enter a valid email address
Please check the format of the address you have entered.
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error