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Chapter 12 : Fecal Microbiota Transplantation: Therapeutic Potential for a Multitude of Diseases beyond

Authors: Guido J. Bakker1, Max Nieuwdorp2
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Affiliations: 1: Department of Internal and Vascular Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, Netherlands; 2: Department of Internal and Vascular Medicine, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, Netherlands; 3: Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; 4: Department of Internal Medicine, VU University Medical Center, Amsterdam, Netherlands
Content Type: Monograph
Publication Year: 2018

Category: Clinical Microbiology; General Interest

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Abstract:

The human intestinal tract contains trillions of bacteria, collectively called the gut microbiota. The majority of bacteria belong to the Gram-negative phyla and and the Gram-positive phyla and ( ). In humans, the diversity of the gut microbiota and the abundance of species increase rapidly after birth and, after 2 to 4 years, remain relatively stable throughout adult life ( ). Nevertheless, shifts in gut microbiota composition may occur, especially after use of antibiotics. Even a short course of antibiotics can result in perturbations that last for several years ( ).

Citation: Bakker G, Nieuwdorp M. 2018. Fecal Microbiota Transplantation: Therapeutic Potential for a Multitude of Diseases beyond , p 291-308. In Britton R, Cani P (ed), Bugs as Drugs. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.BAD-0008-2017
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Fecal Microbiota Transplantation: Therapeutic Potential for a Multitude of Diseases beyond Clostridium difficile
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Citation: Bakker G, Nieuwdorp M. 2018. Fecal Microbiota Transplantation: Therapeutic Potential for a Multitude of Diseases beyond , p 291-308. In Britton R, Cani P (ed), Bugs as Drugs. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.BAD-0008-2017
/content/10.1128/9781555819705.chap12.fig12-1
Figure 1

Causality of the gut microbiota in different diseases. The gut microbiota may have various levels of causality in diffent diseases. Diseases that have a more complex pathophysiology may respond less to fecal microbiota transplantation. ESBL, extended spectrum beta-lactamase producer; VRE, vancomycin-resistant enterococci; IBD, inflammatory bowel disease; IBS, irritable bowel syndrome; T2D, type 2 diabetes. Modified from with permission of the publisher.

10.1128/9781555819705/fig12-1_thmb.gif
10.1128/9781555819705/fig12-1.gif
Image of Figure 1
Figure 1

Causality of the gut microbiota in different diseases. The gut microbiota may have various levels of causality in diffent diseases. Diseases that have a more complex pathophysiology may respond less to fecal microbiota transplantation. ESBL, extended spectrum beta-lactamase producer; VRE, vancomycin-resistant enterococci; IBD, inflammatory bowel disease; IBS, irritable bowel syndrome; T2D, type 2 diabetes. Modified from with permission of the publisher.

Citation: Bakker G, Nieuwdorp M. 2018. Fecal Microbiota Transplantation: Therapeutic Potential for a Multitude of Diseases beyond , p 291-308. In Britton R, Cani P (ed), Bugs as Drugs. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.BAD-0008-2017
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Tables

Fecal Microbiota Transplantation: Therapeutic Potential for a Multitude of Diseases beyond Clostridium difficile
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Citation: Bakker G, Nieuwdorp M. 2018. Fecal Microbiota Transplantation: Therapeutic Potential for a Multitude of Diseases beyond , p 291-308. In Britton R, Cani P (ed), Bugs as Drugs. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.BAD-0008-2017
/content/10.1128/9781555819705.chap12.tab12-1
TABLE 1

Recommended analyses for screening of fecal donors

Generic image for table
TABLE 1

Recommended analyses for screening of fecal donors

Citation: Bakker G, Nieuwdorp M. 2018. Fecal Microbiota Transplantation: Therapeutic Potential for a Multitude of Diseases beyond , p 291-308. In Britton R, Cani P (ed), Bugs as Drugs. ASM Press, Washington, DC. doi: 10.1128/microbiolspec.BAD-0008-2017

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